|Hair Regrowth for Women - from Skin
Women with hair loss or various hair conditions may benefit from copper peptides
treatments. Copper Peptides aids hair health by helping the scalp tissue repair itself
(such as with seborrheic dermatitis or damage from harsh chemicals, sunburn, and hair
- Best in age 40 to 70 group
- Hair shedding often stops within one month
- Hair shafts are often thicker
- Some report strong hair re-growth
- Often reduces itching and flaking associated with scalp inflammation
Dr. Pickart and Skin Biology's recommendations, based on 20 years of successful
research on skin and hair and feedback from many women with hair loss, are:
1. Start with skin repair/hair growth copper peptides
Copper ion complexed with certain peptides has both skin repair and hair growth
enhancement effects. Examples of this are Folligen (from Skin Biology) and Tricomin and
GraftCyte (from ProCyte Corporation). The Proctor Gamble Company has patented as hair
growth compounds a number of copper complexes with peptides such His-Gly-Gly and similar
compounds. In women, hair loss is often associated with scalp irritation or inflammation.
Folligen skin repair properties rapidly restore scalp health.
The copper-peptide concept is based on Iamin, the human body's natural trigger of tissue
renewal (see Copper Peptide Regeneration.) Dr. Pickart invented the copper peptide
that produced Tricomin and GraftCyte while at ProCyte Corporation, which sells the latter
two products. Both GraftCyte for improving the establishment of hair transplants, and
Tricomin for stimulating hair growth, have demonstrated efficacy clinical studies.
Copper-peptides possess significant anti-inflammatory actions which may reduce Alopecia
Areata which is one of the major causes of hair loss in women and generally appears as
patchy loss. Although mild erythema may occur initially, affected areas of scalp or skin
appear normal. This may be anywhere on the scalp or even the rest of the body.
Alopecia areata is an autoimmune disease but without the normal hormonal component in
pattern loss. In simple terms, white blood cells attack the hair roots resulting in loss
of hair. About 30% of individuals with this problem are aware of a relative with this
disorder; thus, there seems also to be a genetic component. There are no good medical
treatments. A variety of approaches are currently used for treatment; all are aimed
at interrupting the "attack" of white blood cells upon the hair roots. The major
therapies include topical and locally injected corticosteroids ; topical minoxidil along
with anthralin; various topical irritants or sensitizers; special light treatments (called
PUVA); and a number of experimental drugs which alter the immune system.
It cannot be accurately predicted when the condition may become occur. An episode might be
precipitated during a illness or a physiologic stress. This type of hair loss may recur at
any time. New patches of hair loss can develop while older patches are being effectively
treated. Sometimes hair will regrow spontaneously over a period of months to years - this
is less likely with more extensive hair loss.
2. For more hair growth add in Minoxidil (2% or 5%)
For more hair stimulation, add in 2% Minoxidil. This can be progressively increased to 5%
Minoxidil. Sometimes minoxidil produces scalp irritation. If this happens, stop the
minoxidil and use only Folligen until your scalp health is restored. Then reuse the 2%
minoxidil and the 5% minoxidil if your scalp remains healthy.
3. Retinoic Acid (useful range 0.01 to 0.05%)
Retinoic Acid may help but some women question this. Retinoic acid (Retin-A) is also
recommended by mnay dermatologists for improving hair growth. However, many women have
indicated that they associated their hair loss with the use of retinoids ranging from
retinoic acid (retin-A) to Accutane.
If retinoic acid is used, the major drawback is often strong scalp irritation. Folligen,
used lightly, can greatly reduce this irritation. Sometimes, the combination of minoxidil
and retinoic acid causes breaks in the skin barrier.
4. The addition of estrogen or a DHT blocker may help in some cases
Estrogens, the feminizing hormones, can inhibit or counteract the follicle-shrinking
effect of the androgens. Women have more estrogens circulating in their blood than men. As
a result of this higher level of estrogens, even women having a genetic predisposition for
pattern hair loss are protected from losing their hair because of the high level of
estrogens in their blood. When these women reach menopause however, their estrogen level
may decrease sufficiently, and the protective effect of the estrogen may be
overridden by the DHT message. Then hair can begin to thin, sometimes rapidly. Some women
who are genetically pre-disposed to have pattern hair loss.
This type of hair loss or Androgenetic Alopecia or pattern baldness affects over 70% of
men but also 15% of women where the hair loss pattern tends to be diffuse and over a
broader area. Women usually do not develop bald spots, but rather have overall thinning
hair. In such diffuse hair loss in women, over 50% of the hair can be lost before the
results are readily apparent.
Estrogen supplementation can raise estrogen levels, and help restore the emotional and
physical condition of the patient to the pre-menopause states. It may also slow or stop
hair loss triggered by menopause. While hormone replacement therapy has been a
controversial treatment for menopause, newer methods are finding overall reductions both
in the risk of some cancers and in the risk of heart diseases.
The best known DHT (dihydrotestosterone) blocker is Propecia®, the drug from Merck, but
Merck does not recommend Propecia for women: a one year study of hair growth in 136
post-menopausal women found no significant effect of Propecia on hair growth.
Non-drug DHT Blockers include saw palmetto oil, pygeum and nettle root
extract, the soybean isoflavones genistein and daidzien, and ginkgo biloba.
Saw palmetto has been used for over 400 years as a herbal treatment for enuresis,
nocturia, atrophy of the testes, impotence, inflammation of the prostate, and as a mild
aphrodisiac for men. Women used the berries to treat infertility, painful periods and
problems with lactation.
Extracts of two plants, pygeum bark (Pygeum africanum) and nettle root (Urtica dioica) are
widely used for the treatment of prostate hyperplasia.
Isoflavonoids, such as genistein and daidzein are weak estrogens and may lessen the risk
of osteoporosis and heart disease. Several studies have found a protective effect of
isoflavones against the development of cancer. The Chinese report that daidzien
exhibits hair growth and hair color promoting activity. Some Folligen users have reported
good hair regrowth when combined with oral intake of bioflavinoids.
Ginkgo biloba is a popular herb used world wide to improve cerebral blood flow and general
blood circulation. It was recently reported by the Journal of the American Medical
Association to slow the progression of Alzheimer's disease. It has been reported to
inhibit 5-alpha reductase activity.
5. High level exercise training may cause hair loss
In women, severe exercise tends to reduce estrogen and raise testosterone. This can lead
to a stopping of the menstrual cycle and more brittle bones. While there are many positive
aspects of exercise training, this effect on hair should be kept in mind since it can
increase the rate of hair loss.
6. Sudden hormone shifts can cause hair loss
In women hair loss can become severe after giving birth to a child or after
discontinuation of oral contraceptives (birth control pills). The In these cases, a brief
therapy with hair stimulators can usually restore hair to its previous condition.
One of the most sought after copper peptides based topical hair treatment is
Folligen. Folligen is a non-drug product designed by Dr. Loren Pickart to improve scalp
and hair follicle health and hair vitality. Dr. Loren Pickart is the inventor of many
clinically-proven products for the hair and scalp health such as products for hair
transplantation sold as the GraftCyte® Advanced Hair Restoration Technology for improving
the success of hair transplants consisting of: GraftCyte® Moist Dressings,
GraftCyte® Hydrating Mist, GraftCyte® Post-Surgical Shampoo & Conditioner, and
GraftCyte® Head Start Single Patient Pack. Other inventions produced the Tricomin®
system for treatment of thinning hair consisting of the Tricomin® Solution Follicle
Therapy Spray, Tricomin® Revitalizing Shampoo, Tricomin® Restructuring Conditioner and
Tricomin® Conditioning Shampoo.
Advising Skin Biology on hair growth methods is Prof. Hideo Uno, one the the world's
leading researchers on hair growth. Dr. Uno conducted much of the early work on Rogaine
(minoxidil) and wrote the standard monograph on Rogaine that was distributed by Upjohn
Folligen had its beginning as a skin repair cream that was being tested in the Dermatology
Department at the University of California at San Francisco. A 41-year-old woman
with severe hair loss tried one of Dr. Pickart's skin repair creams because nothing else
had worked to restore her lost hair. In two and one/half months she regained all her lost
hair. Other people began using our skin repair cream to counter hair loss and. in time,
Folligen emerged as a distinct product.
Folligen's biological effect on hair is similar to other copper-peptide products such as
Graftcyte and Tricomin which are skin repair products that aid hair growth and scalp
Folligen is sold in three versions: (1) Folligen Cream which that works well on
hairlines, (2) a more-liquid Folligen Lotion for using in areas of denser hair, and (3)
Folligen Solution Therapy Spray which can be sprayed as a fine mist into the hair.
Folligen is especially useful in helping to reduce scalp irritation caused by other hair
growth products such as Rogaine® (minoxidil), Retin-A® (retinoic acid) and Propecia®.
Compare Folligen Cream or Folligen Lotion at $18.95 and Folligen Solution Therapy Spray
for $33.95 to Tricomin Solution Follicle Therapy Spray® sold by ProCyte for $48.00 and
GraftCyte Solution® for $125.00 which are products based on Dr. Pickart's earlier hair
All Folligen products contain a high concentration of blue-colored
copper-peptide complexes and do not contain any blue dyes or scalp damaging detergents or
alcohol. Tricomin contains blue dyes apparently to give the impression of more
copper-peptide complexes. Folligen Solution Therapy Spray uses small amounts of
polysorbate 20 and propylene glycol to enhance the uptake of copper-peptide around the
Application of Folligen:
Step 1: Use Folligen Lotion, Cream or Spray to get your scalp in good
shape. Apply a thin coating of Folligen cream or lotion or Folligen Spray to the scalp.
The Cream is better for the hairline and the Lotion and Spray are easier to apply into
heavier hair. Folligen is usually applied before bedtime. If desired, you may shampoo the
Folligen out in the morning. Then start using 2% minoxidil along with Folligen. If this is
not irritating, move up to Folligen and 5% minoxidil.
Apply the minoxidil and let it dry for about a minute, then apply the Folligen.
Step 2. If your scalp become irritated stop the minoxidil but continue Folligen. When your
scalp is OK again, resume the progressive use of minoxidil and start again with 2% and
move up to 5%.
After a number of cycles of steps 1 and 2, your skin should adjust and you should be able
to use both together.
While this 2-Step System works very well, many say that Folligen alone has sufficiently
solved their hair problems.
Folligen is a marked improvement over Pickart's previous inventions for hair growth
stimulation. Three US Patents 5,382,431; 5,554,375; 5,698,184 have issued on this
technology which strongly assists skin renewal and hair follicle regeneration.
Dr. Pickart via HairSite Editorial
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