Copper Peptide products are often used to enhance scalp and new hair health and
hair growth after transplant procedures. Such hair often recovers slowly from shock of
transplantation. Copper-peptide products can enhance the health of transplants and lead to
an increased number of viable hair shafts.
Copper-peptides were first used in 1984 for skin transplantation . The bathing of skin
transplants in 1% copper-peptide solutions produced greatly improved graft acceptance. The
inclusion of 5% DMSO in the copper-peptide mixture improved transplant acceptance even
further.
A new product based on patents by Dr. Loren Pickart, which is called GraftCyte, when used
in the post-operative regimen has resulted in faster healing of transplants and earlier
regrowth of the hair shafts. GraftCyte is a copper peptide based on the Iamin tissue
regenerative concept. (For details, visit Copper Peptide Regeneration.) The GraftCyte
dressing provides enhanced healing of the transplanted follicle. It results in less
post-operative shedding along with a more immediate hair growth. Patients often see new
hair growth in 6 weeks versus the normal 10 to 14 weeks. The normal skin crusting after
transplantation has been reduced from 10 to 14 days to 5 days in most cases. GraftCyte
costs about $275 per procedure and can be obtained from www.procyte.com/.
In a study of Graftcyte by Perez-Meza et al, (International Journal of Cosmetic Surgery
(Vol. 6, 1998, pp 80-84), it was found that men and women receiving transplants and using
GraftCyte for post-operative treatment achieved better results and a quicker healing time
in comparison the conventional saline gauze dressing used after surgery. In a
placebo-controlled, double blinded study of twelve patients were studied over a 13 week
period, each patient received 16 treatments during 4 days post-surgery. On each patient,
one side of the head was treated with conventional and the other with Graftcyte. Each
patient received a conventional saline gauze dressing on one side of the head and
GraftCyte on the other in a pre-assigned random scheme. Weekly results were documented by
photographs and video microscopic scans. The study measured edema (excess fluid buildup
and crusting), effluvium (shedding of transplanted hair), erythema (redness of the skin),
the growth of transplanted hair that did not shed, and the regrowth of transplanted hair
that returned after shedding plus overall cosmetic results.
In the Graftcyte treated areas, 42% of patients were found to exhibit less redness and
crusting than on the placebo side vs 17% who were better with the saline; on the placebo
side. Redness and crusting were slightly milder in the Graftcyte treated group (75%
none tomild for GraftCyte and 58% for placebo). The GraftCyte treated side showed better
hair regrowth at 4, 8, and 12 weeks compared to the placebo side. The patients felt that
the GraftCyte treated hairs had greater body, shine, and texture than the placebo-treated
side.
Effect of Graftcyte on Growth Transplanted Hair
(0=none, 1=mild, 2=moderate, 3=extensive)
| |
Placebo - Average Score |
GraftCyte - Average Score |
| Week 4 |
1.3 |
1.6 |
| Week 8 |
1.3 |
1.8 |
| Week 12 |
1.3 |
1.9 |
Compare to Concentrated Graftcyte Solution® 5.7 ounces for
$125.00.
Folligen Solution has 9.0 times more copper peptide per ounce.
Other more advanced copper-peptide skin and hair growth accelerators are also
available from Protect & Restore and Folligen which some physicians used after
transplant. These accelerators have been proven effective in skin repair studies, and
stimulate hair growth in mouse models, but as yet have not undergone controlled studies on
hair transplantation.
For clinical data on Skin Biology’s www.skinbio.com skin
healing accelerators see: (1) Zhai, Leow, and Maibach, "Sodium lauryl sulfate damaged
skin in vivo in man: a water barrier repair model", Skin Research and Technology,
Volume 4, pages 24-27, 1998. Skin Biology's product markedly accelerated the repair of
skin damaged by the application of an irritating detergent. (2) Zhai, Poblete, and
Maibach, "Stripped skin model to predict irritation potential of topical agents in
vivo in man", International Journal of Dermatology, Volume 37, pages 386-389, 1998;
Skin Biology product increased skin repair after skin removal by repeated tape-stripping.
(3) Zhai, Leow, and Maibach, "Human barrier recovery after acute acetone
perturbation: an irritant dermatitis model", Clinical and Experimental Dermatology,
Volume 23, pages 11-13, 1998. Skin was damaged by a fat removing agent, acetone, then
treated with a Skin Biology product which rapidly rebuilt the damaged skin, and (4) Zhai,
Chang, Singh, and Maibach, "An in vivo nickel allergy contact dermatitis human model
for topical therapeutics", Presented in February 1998, American Academy of
Dermatology Meeting. Skin was damaged by the application of nickel salts to persons with
nickel allergy. The Skin Biology product increased skin repair and reduced skin
irritation.
Dr. Pickart via HairSite Editorial
Back to Cyber
Conference on Copper Peptides
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