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HairSite Admin 26.01.2009, 07:21	Antiandrogens (Androgenetic Alopcia (AGA) Female Pattern) Post reply
	Antiandrogens There are three antiandrogens that may be used in FPHL that are approved in various countries for various indications. For example, spironolactone is approved in the USA as a diuretic for the treatment of hypertension and in Australia as a treatment for hirsutism; flutamide is approved in the USA as a treatment for prostate cancer in combination with a luteinizing hormone-releasing hormone; and cyproterone acetate is unavailable in the USA but is approved in Britain as a treatment for acne and hirsutism. Each has its own advantages and disadvantages in the treatment of FPHL with multicenter controlled comparative efficacy trials lacking in this disorder. All can cause feminization of a male fetus in a pregnant woman taking the drug and thus an effective means of contraception must be in place at the time of initiating treatment with one of these drugs and for the duration of therapy. HairSite Admin is located in [NA] and he is available to meet: NO --- I offer research assistance for HairSite. email: hairsite@aol.com for free consultations ===================================== reminder: 1. FREE Hair Replacement System Worldwide
HairSite Admin 27.01.2009, 12:54 @ HairSite Admin	Spironolactone Post reply
	Spironolactone Spironolactone, as an antiandrogen, blocks both the production of testosterone in the adrenal gland. The minimally effective dose of spironolactone appears to be 100 mg per day, a dosage based more on the treatment of hirsutism than alopecia, with the usual doses given being 100–200 mg per day. There are no studies to address a dose effect in FPHL and published results of >100 mg per day are primarily on cohorts of fewer than ten women.However, there is one 12-month trial of spironolactone 200 mg per day in 40 women with FPHL with documented efficacy in 45% of women. Despite a lack of further documentation of efficacy, spironolactone is used regularly in the women with documented hyperandrogenism. Hyperkalemia ia a potential side-effects of spironolactone related to its aldosterone antagonist/potassium sparing effect on the kidney, and potassium levels should be checked after starting the drug. Since spironolactone may cause breast tenderness, irregular menses and mood swings,it is wise to put women of child-bearing potential on an oral contraceptive agent prior to beginning spironolactone. There is one oral contraceptive agent, Yasmin®, whose 3 mg of progesterone (drospirenone) has an inherent spironolactone-like effect equivalent to 25 mg of spironolactone, not enough by itself to expect to see an effect on FPHL HairSite Admin is located in [NA] and he is available to meet: NO --- I offer research assistance for HairSite. email: hairsite@aol.com for free consultations ===================================== reminder: 1. FREE Hair Replacement System Worldwide
HairSite Admin 28.01.2009, 13:25 @ HairSite Admin	Flutamide Post reply
	Flutamide Flutamide, or its metabolite 2-hydroxy-flutamide, is a non-steroidal pure antiandrogen with no intrinsic androgenic activity. It inhibits the binding of testosterone to the androgen receptor. Flutamide has been evaluated only in women with hair loss who also have hyperandrogenism. Carmina and Lobo evaluated 250 mg of flutamide daily versus cyproterone acetate versus finasteride versus observation alone in 48 women (12 women in each group) with FPHL and documented hyperandrogenism.The flutamide group had a statistically significant improvement in the Ludwig score and in the investigator assessment over the observation group. Extrapolation from anecdotal reports in women with hirsutism who also had hair loss showed that 250 mg of flutamide twice daily in combination with an oral contraceptive agent had cosmetically acceptable growth in six out of seven women and may have efficacy in alopecia beyond that of spironolactone. Its primary side-effects are gastrointestinal including diarrhea although the use of flutamide is limited by its known hepatotoxicity, which can be fatal. HairSite Admin is located in [NA] and he is available to meet: NO --- I offer research assistance for HairSite. email: hairsite@aol.com for free consultations ===================================== reminder: 1. FREE Hair Replacement System Worldwide
Jessie 30.01.2009, 01:51 @ HairSite Admin	Antiandrogens Post reply
	» Antiandrogens » » There are three antiandrogens that may be used in FPHL that are approved » in various countries for various indications. » » For example, spironolactone is approved in the USA as a diuretic for the » treatment of hypertension and in Australia as a treatment for hirsutism; » » flutamide is approved in the USA as a treatment for prostate cancer in » combination with a luteinizing hormone-releasing hormone; and » » cyproterone acetate is unavailable in the USA but is approved in Britain » as a treatment for acne and hirsutism. » » Each has its own advantages and disadvantages in the treatment of FPHL » with multicenter controlled comparative efficacy trials lacking in this » disorder. » » All can cause feminization of a male fetus in a pregnant woman taking the » drug and thus an effective means of contraception must be in place at the » time of initiating treatment with one of these drugs and for the » duration of therapy. Thank you for the information Antiandrogens.Apart from all this I would like to share one thing for the beauticians regarding their business that to maintain their customer’s record easily they should go with an inventory management system www.qtinventory.com . This is an bonus to the beauticians for their business. Jessie is located in [NA] and he is available to meet: NO
Nutmeg Canada, 06.02.2009, 19:10 @ Jessie	Antiandrogens Post reply
	How successfull are these drugs? I realize everyone responds differently to each one and it takes time. Can you take a moment to read my post under "Androgentic Alopecia" Topics (Proscar/Finasteride - by Nutmeg). Any information you have would be great! Thanks! » » Antiandrogens » » » » There are three antiandrogens that may be used in FPHL that are » approved » » in various countries for various indications. » » » » For example, spironolactone is approved in the USA as a diuretic for » the » » treatment of hypertension and in Australia as a treatment for hirsutism; » » » » » flutamide is approved in the USA as a treatment for prostate cancer in » » combination with a luteinizing hormone-releasing hormone; and » » » » cyproterone acetate is unavailable in the USA but is approved in » Britain » » as a treatment for acne and hirsutism. » » » » Each has its own advantages and disadvantages in the treatment of FPHL » » with multicenter controlled comparative efficacy trials lacking in this » » disorder. » » » » All can cause feminization of a male fetus in a pregnant woman taking » the » » drug and thus an effective means of contraception must be in place at » the » » time of initiating treatment with one of these drugs and for the » » duration of therapy. » » » » » Thank you for the information Antiandrogens.Apart from all this I would » like to share one thing for the beauticians regarding their business that » to maintain their customer’s record easily they should go with an inventory » management system www.qtinventory.com . This is an bonus to the beauticians » for their business. Nutmeg is located in CANADA and he is available to meet: NO --- **Nutmeg**
HairSite Admin 07.02.2009, 13:30 @ HairSite Admin	Cyproterone Acetate Post reply
	Cyproterone Acetate Cyproterone acetate blocks DHT-androgen receptor binding and, given its steroid structure, has progestogen and antigonadotropic properties. In women of child-bearing potential, estrogens are usually given with cyproterone acetate to reinforce the latter effect and to ensure regular menses. Two combinations of cyproterone acetate with 50 μg ethinyl estradiol are utilized for their antiandrogen effect in premenopausal women: (1) 100 mg along with estrogen on days 5–15 and estrogen alone on days 16–25 (cyclical antiandrogen therapy or CAT) for hirsutism or (2) 2 mg in combination with estrogen on days 5–25 (Diane®). In postmenopausal women, 50 mg of cyproterone acetate daily may be used alone. Potential side-effects are dose related and include menstrual irregularity, weight gain, breast tenderness, decreased libido, depression, and nausea. There have been few controlled clinical trials of cyproterone acetate in FPHL. In one study 20 female patients with AGA were treated for 1 year with daily 50 μg ethinyl estradiol and 2 mg cyproterone acetate (Diane®) plus an additional 20 mg cyproterone acetate on days 5–20 of the menses and were compared to 10 untreated control patients with AGA for 1 year . Trichogram results as well as hair diameter on the fronto-cranial and temporal scalp were assessed. There was a statistically significant increase in the anagen/telogen ratio but no decrease in vellus hairs on the fronto-cranial scalp in the cyproterone acetate group compared to controls. In another study, 40 patients with FPHL were treated with cyproterone acetate for 12 months, 22 postmenopausal women with 50 mg cyproterone acetate daily, and 18 premenopausal women with 100 mg cyproterone acetate daily for 10 days each month along with a combination oral contraceptive pill [89]. Of 40 women, 17 (42.5%) had a positive response documented photographically. These results were almost identical to the comparative group of 40 patients treated with spironolactone. A 48-week trial conducted by Vexiau et al. included equal numbers of women (33 each group) with female AGA treated with 52 mg per day of cyproterone acetate plus ethinyl estradiol 35 μg for 20 of every 28 days or 2% topical minoxidil solution 1 ml bid plus combined oral contraceptive use [105]. Between baseline and 12 months, there was no significant difference in the mean number of target area hairs in the cyproterone group but an increase in the minoxidil group. There was no difference in the results with cyproterone acetate and FPHL with the presence or absence of other signs of hirsutism. Dawber et al. has suggested that there is a minimally effective dose of cyproterone acetate, as 24 out of 29 women had improvement in FPHL when treated with 50 μg ethinyl estradiol and 200 mg cyproterone acetate daily but 14 of 17 who remained on Diane® (2 mg cyproterone acetate) failed to maintain that response. HairSite Admin is located in [NA] and he is available to meet: NO --- I offer research assistance for HairSite. email: hairsite@aol.com for free consultations ===================================== reminder: 1. FREE Hair Replacement System Worldwide