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Diagnostic criteria for PCOS (PCOS & Hair Loss)

posted by HairSite Admin, 09.05.2008, 22:31

Diagnostic Criteria in Polycystic Ovary Syndrome (PCOS)



Revised diagnostic criteria of PCOS -1999 criteria (both 1 and 2)

1. Chronic anovulation

2. Clinical and/or biochemical signs of hyperandrogenism, and exclusion of other aetiologies



Revised 2003 criteria (2 out of 3)

1. Oligo- and/or anovulation

2. Clinical and/or biochemical signs of hyperandrogenism

3. Polycystic ovaries

and exclusion of other aetiologies (congenital adrenal hyperplasias, androgen-secreting tumours, Cushing’s syndrome)



Other Proposed Diagnostic Criteria in Polycystic Ovary Syndrome

1. Inappropriate gonadotropin secretion

a)Elevated LH-to-FSH ratio

b)Abnormal response to GnRH agonist testing


2. Hyperandrogenism

a)Hirsutism, androgenic alopecia, acne

b)Hyperandrogenemia

I.Total testosterone

II.Free testosterone (free androgen index, etc.)


3.Ovarian appearance

a) Polycystic-appearing ovaries

b)Increased (stromal) size


4.Insulin resistance

a)Acanthosis nigricans

b)Fasting measures of insulin/glucose

c)Oral glucose tolerance test

d)Dynamic tests of insulin sensitivity

I.Euglycemic clamp

II.Frequently sampled intravenous glucose tolerance test

5.Chronic anovulation

a)Self-reported history

b)Tests of ovulatory function

I.Basal body temperature charting

II.Urinary LH testing

III.Serum progesterone measurement

IV.Endometrial biopsy

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