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Menopause Vs. Loss when younger (Menopause, Peri-menopause & Hair Loss)

posted by HairSite Admin, 11.06.2008, 12:26

I have posted a few studies in the other thread with the same topic you have started.
I could not get the English version for the full text though the abstract is in English.

Here is another study done in premenopausal women -

Treatment of hyperandrogenic alopecia in women

Fertil Steril. 2003 Jan;79(1):91-5

OBJECTIVE:
To determine the effectiveness of various antiandrogens for the treatment of premenopausal women with hyperandrogenic alopecia.

DESIGN:
Randomized, unmasked trial of three treatments in 36 hyperandrogenic women with alopecia and observation, without treatment, in 12 other similar patients.

SETTING:
Endocrinologic outpatient practice in Italy.

PARTICIPANT(S):
A total of 48 hyperandrogenic women with alopecia and 30 age- and weight-matched controls for the assessment of androgen levels.

INTERVENTION(S):
Randomization to cyproterone acetate (50 mg) with ethinyl estradiol (EE) in a reverse sequential regimen; flutamide (250 mg) or finasteride (5 mg) daily; all for 1 year. Twelve similar patients were observed without treatment for 1 year.

MAIN OUTCOME MEASURE(S):
Ludwig scores for hair thinning as well as patient and investigator assessments of treatment effectiveness. RESULT(S): Flutamide resulted in a reduction of 21% in Ludwig scores (2.3 +/- 0.2 to 1.8 +/- 0.1). The other treatment effects were not statistically significant. Patient and investigator assessments showed a similar trend.

CONCLUSION(S):
Flutamide at a dose of 250 mg daily induced a modest improvement in alopecia after 1 year, whereas cyproterone acetate and finasteride were not effective. Treatment for more than 1 year may be required for better results.


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