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Sexual hormones in human skin (Support Forum & Misc Topics)
» Sexual hormones in human skin
»
» Horm Metab Res. 2007 Feb;39(2):85-95
»
» The skin locally synthesizes significant amounts of sexual hormones with
» intracrine or paracrine actions. The local level of each sexual steroid
» depends upon the expression of each of the androgen- and
» estrogen-synthesizing enzymes in each cell type, with sebaceous glands and
» sweat glands being the major contributors.
»
» Sebocytes express very little of the key enzyme, cytochrome P450c17,
» necessary for synthesis of the androgenic prohormones
» dehydroepiandrosterone and androstenedione, however, these prohormones can
» be converted by sebocytes and sweat glands, and probably also by dermal
» papilla cells, into more potent androgens like testosterone and
» dihydrotestosterone. Five major enzymes are involved in the activation and
» deactivation of androgens in skin.
»
» Androgens affect several functions of human skin, such as sebaceous gland
» growth and differentiation, hair growth, epidermal barrier homeostasis and
» wound healing. Their effects are mediated by binding to the nuclear
» androgen receptor. Changes of isoenzyme and/or androgen receptor levels may
» have important implications in the development of hyperandrogenism and the
» associated skin diseases such as acne, seborrhoea, hirsutism and
» androgenetic alopecia.
»
» On the other hand, estrogens have been implicated in skin aging,
» pigmentation, hair growth, sebum production and skin cancer. Estrogens
» exert their actions through intracellular receptors or via cell surface
» receptors, which activate specific second messenger signaling pathways.
»
» Recent studies suggest specific site-related distribution of ERalpha and
» ERbeta in human skin. In contrast, progestins play no role in the
» pathogenesis of skin disorders. However, they play a major role in the
» treatment of hirsutism and acne vulgaris, where they are prescribed as
» components of estrogen-progestin combination pills and as anti-androgens.
»
»
» These combinations enhance gonadotropin suppression of ovarian androgen
» production. Estrogen-progestin treatment can reduce the need for shaving by
» half and arrest progression of hirsutism of various etiologies, but do not
» necessarily reverse it. However, they reliably reduce acne.
»
» Cyproterone acetate and spironolactone are similarly effective as
» anti-androgens in reducing hirsutism, although there is wide variability in
» individual responses.
It should read decrease of estrogen promotes skin aging, it definitely helps with wound healing. It's often applied topically to promote healing.
delilah is located in [NA] and he is available to meet: NO
Complete thread:
- Sexual hormones in human skin
- HairSite Admin, 12.06.2008, 10:46
- Sexual hormones in human skin - delilah, 12.06.2008, 15:30
- Sexual hormones in human skin - HairSite Admin, 12.06.2008, 22:30
- Sexual hormones in human skin - delilah, 12.06.2008, 15:30