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Spironolactone (Androgenetic Alopcia (AGA) Female Pattern)

posted by HairSite Admin, 27.01.2009, 12:54

Spironolactone

Spironolactone, as an antiandrogen, blocks both the production of testosterone in the adrenal gland.

The minimally effective dose of spironolactone appears to be 100 mg per day, a dosage based more on the treatment of hirsutism than alopecia, with the usual doses given being 100–200 mg per day. There are no studies to address a dose effect in FPHL and published results of >100 mg per day are primarily on cohorts of fewer than ten women.However, there is one 12-month trial of spironolactone 200 mg per day in 40 women with FPHL with documented efficacy in 45% of women. Despite a lack of further documentation of efficacy, spironolactone is used regularly in the women with documented hyperandrogenism.

Hyperkalemia ia a potential side-effects of spironolactone related to its aldosterone antagonist/potassium sparing effect on the kidney, and potassium levels should be checked after starting the drug. Since spironolactone
may cause breast tenderness, irregular menses and mood swings,it is wise to put women of child-bearing potential on an oral contraceptive agent prior to beginning spironolactone. There is one oral contraceptive agent,
Yasmin®, whose 3 mg of progesterone (drospirenone) has an inherent spironolactone-like effect equivalent to 25 mg of spironolactone, not enough by itself to expect to see an effect on FPHL


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Complete thread:

• Antiandrogens - HairSite Admin, 26.01.2009, 07:21 (Androgenetic Alopcia (AGA) Female Pattern)
  • Spironolactone - HairSite Admin, 27.01.2009, 12:54
  • Flutamide - HairSite Admin, 28.01.2009, 13:25
  • Antiandrogens - Jessie, 30.01.2009, 01:51
    • Antiandrogens - Nutmeg, 06.02.2009, 19:10
  • Cyproterone Acetate - HairSite Admin, 07.02.2009, 13:30