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Flutamide (Androgenetic Alopcia (AGA) Female Pattern)

posted by HairSite Admin, 28.01.2009, 13:25

Flutamide

Flutamide, or its metabolite 2-hydroxy-flutamide, is a non-steroidal pure antiandrogen with no intrinsic androgenic activity. It inhibits the binding of testosterone to the androgen receptor.

Flutamide has been evaluated only in women with hair loss who also have hyperandrogenism. Carmina and Lobo evaluated 250 mg of flutamide daily versus
cyproterone acetate versus finasteride versus observation alone in 48 women (12 women in each group) with FPHL and documented hyperandrogenism.The flutamide group had a statistically significant improvement in the Ludwig score and in the investigator assessment over the observation group. Extrapolation from anecdotal reports in women with hirsutism who also had hair loss showed that 250 mg of flutamide twice daily in combination with an oral contraceptive agent had cosmetically acceptable growth in six out of seven women and may have efficacy in alopecia beyond that of spironolactone.

Its primary side-effects are gastrointestinal including diarrhea although the use of flutamide is limited by its known hepatotoxicity, which can
be fatal.


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Complete thread:

• Antiandrogens - HairSite Admin, 26.01.2009, 07:21 (Androgenetic Alopcia (AGA) Female Pattern)
  • Spironolactone - HairSite Admin, 27.01.2009, 12:54
  • Flutamide - HairSite Admin, 28.01.2009, 13:25
  • Antiandrogens - Jessie, 30.01.2009, 01:51
    • Antiandrogens - Nutmeg, 06.02.2009, 19:10
  • Cyproterone Acetate - HairSite Admin, 07.02.2009, 13:30