hairmax lasercomb

instant hair thickening fibers

Origenere TR1 hair formula

FREE ADS


Shop

Hair Loss: Azelaic Acid

Background: Azelaic acid (pronounced az-uh-LAY-ic) is a simple molecule ( HOOC(CH2)7COOH, CAS Number 123-99-9, also known as 1,9-Nonanedioic acid) that is found in some whole grains and in trace amounts in human bodies. Although it is an acid, it is an extremely weak acid - much weaker than vinegar. It's current use in medicine is in Azelex or Skinoren, which is a cream base containing azelaic acid as 20% of its weight. Azelex is available by prescription in the USA and is used in the treatment of acne. Skinoren is available outside USA.

Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it and zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor. The enzyme 5-AR (both types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to male prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles.

Abstract of Stamatiadis' 1988 study:

Br J Dermatol 1988 Nov;119(5):627-632 Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.

Stamatiadis D, Bulteau-Portois MC, Mowszowicz I

Laboratoire de Biochimie B, Hopital Necker-Enfants-Malades, Paris, France.

The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.

PMID: 3207614, UI: 89087983

The reservations one might have regarding the Stamatiadis study are (1) that the study was done on rats, (2) that is was done on prostate tissue (and not on hair tissue) and (3) that it was done "in vitro" (essentially means, "not in a living organism"). Cells in living tissue generally show a considerable ability to protect themselves from invasion. Treating pure 5-AR directly with azelaic acid in a lab flask is somewhat different from exposing the living cell to azelaic acid. Nevertheless, what happens "in vitro" often reveals clues as to what might happen "in vivo" (in a living organism).

Side effects: Some of the possible side effects associated with azelaic acid are white spots or lightening of treated areas of dark skin or patients with dark complexions, although usually not lightened beyond normal skin color. Other side effects include burning, stinging, or tingling of skin, mild, dryness of skin, itching of skin, peeling of skin, redness of skin. Results from the U.S. clinical trials with AZELEX® show that adverse reactions were generally mild and temporary in nature. The most common adverse reactions occurring in approximately 1-5% of patients were pruritus, burning, stinging and tingling. Other such as erythema, dryness, rash, peeling, irritation, dermatitis, and contact dermatitis were reported in less than 1% of test subjects.

Vendors:
Azelaic acid together with topical zinc and B6 (brand name Crinagen) can be purchased from Dr. Razack.

Topical minoxidil that includes azelaic acid can be purchased from Dr. Oscar Klein.

Azelaic acid cream, 20% concentration (brand name Skinoren) can be purchased from pharmacy.


Questions about Hair Loss?
Answers within 48 hours
read
PRIVACY STATEMENT first
Your E-Mail Gender
Age
City, Sate, Country
Your Questions:


  

Featured Doctors

  sponsoring physicians
 
Alvi Armani
Dubai Hair Transplant
Beverly Hills Hair Transplant
  
Dr. Arvind
Hair Transplant India

  
Dr. Bisanga
Hair Transplant Europe
 
 
Dr. Umar
Los Angeles Hair Transplant
 

Drs. Hasson & Wong
Vancouver Hair Transplant
 
 
HDC Hair Clinic
Europe Hair Transplant
London Hair Transplant

  
Dr. Jones
Toronto Hair Transplant
 
     
Dr. Woods
Sydney Hair Transplant

  
Dr. Cole
Atlanta Hair Transplant
Hair Transplant Asia

Dr. Rashid
Houston, Texas hair transplant

Dr. Vivek Nigam
Mumbai India hair transplant

Dr. Klein's Formula
FREE CONSULTATION
with Dr. Klein

 
instant hair thickening fibers

All Inclusive Haircare Hair Restoration Guide

Hair Transplant
hair loss treatmentHair Transplant Reviews
hair loss treatmentBest Hair Transplant
hair loss treatment
Hair Transplant Repair
Hair transplant doctor
Featured doctors
Hair Replacement
Hair replacement
Hair extensions
Hair wigs
Salon & Haircare
Hair salon directory
beauty & hair salon guide
salon & beauty supplies
Gray Hair
Other
hair loss treatmentHair Loss Articles
Knowledge Base
Hair Loss Books
Consumer Alerts
Women hair loss
Dermatologists
Lasercomb
Event Calendar

sponsors
 

HairSite.com 1997 - 2013 © copyright | hairsite@aol.com | Privacy Statement | Terms of Use | Copyright Policy
 
London Hair Replacement | Hair Replacement UK | Hair Replacement Australia
 Medical Hair Restoration | Bosley Hair Transplant | Hair Club | Hair Transplant Boston
Hair Replacement Athens | Hair Transplant Texas | Los Angeles Hair Replacement | Hair Replacement DC
 Hair Transplant San Diego | Las Vegas Hair Transplant | Sacramento Hair Transplant | San Francisco Hair Transplant
Hair Transplant Miami | New Jersey Hair Transplant | Dr Feller Hair Transplant | Bernstein Hair Transplant
Hair Transplant Montreal | Hair Transplant New York | Hair Transplant Turkey | Hair Transplant Pakistan
 
hair restoration


HairSite sponsors: Alvi Armani | Dr. Bhatti | Dr. Bisanga | Dr. Cole | Dr. Epstein | Dr. Jones | Dr. Klein | Dr. Madhu | Dr. Nigam | Dr. Poswal | Dr. Razack | Dr. Umar | Dr. Ray Woods | HDC Clinic | HairDirect | HIS Hair Clinic | Revivogen | Lasercomb | DHI | TRX2 | Wilshire Wigs | Ziering Medical

Fill out your e-mail address to receive our newsletter!

Email    gender    city,country