Hair Loss: Corticosteroid, Betamethasone, Hydrocortisone
About Betamethasone: Betamethasone is a kind of topical corticosteroids commonly prescribed for the treatment of skin and scalp disorders such as severe psoriasis, itching, redness, dryness, crusting, scaling, eczema, and inflammation etc. Corticosteroids are anti-inflammatory medicines. Inflammation of the skin happens due to the irritation of the skin, and is caused by the release of various substances that are important in the immune system. These substances cause blood vessels to widen, resulting in the irritated area becoming red, swollen, itchy and painful.
corticosteroids remain one of the most widely used treatment modalities
for psoriasis. Corticosteroids have anti-inflammatory, immunosuppressive
and antiproliferative properties. They bind to a receptor in the
cytoplasm of cells and are transported to the nucleus, where they affect
gene transcription. The efficacy of an individual topical corticosteroid
is related to its potency and its ability to be absorbed into the skin.
application: Use topically as directed. If you are using topical
minoxidil separately, try to apply minoxidil prior to betamethasone.
Comparing the strength of various corticosteroids
1) Comparison of a modified hydrocortisone/urea cream and betamethasone valerate cream in the treatment of dry eczema.
Comparison of the effect of hydrocortisone, hydrocortisone-17-butyrate
and betamethasone on collagen synthesis in human skin in vivo.
Haapasaari KM, Risteli J, Koivukangas V, Oikarinen A.
Fourteen healthy male volunteers applied hydrocortisone, hydrocortisone-17-butyrate, betamethasone and vehicle twice a day for one week to four separate areas marked on their abdominal skin. The collagen synthesis rate in the skin was measured by assaying collagen propeptides from the suction blisters induced on the treated areas. Aminoterminal propeptide of type I procollagen (PINP) and aminoterminal propeptide of type III procollagen (PIIINP) were measured from skin blister fluid using radioimmunoassays. Skin thickness was measured with ultrasound. Hydrocortisone decreased the two propeptides studied in the suction blister fluids less than did hydrocortisone-17-butyrate and betamethasone, but the interindividual variation was great. Hydrocortisone-17-butyrate and betamethasone had almost similar decreasing effects on the propeptides in the suction blister fluid. Hydrocortisone decreased the concentrations of PINP and PIIINP by about 35%. In some subjects (4/14) the decline of the collagen propeptide levels was over 50%. The decline in the concentration of PINP was 63% by hydrocortisone-17-butyrate and 69% by betamethasone, while the decrease in PIIINP was 55% by hydrocortisone-17-butyrate and 62% by betamethasone. None of the treatments had any effect on skin thickness within one week.
In conclusion, it seems that hydrocortisone is less atrophogenic than hydrocortisone-17-butyrate and betamethasone, as shown by radioimmunoassays for collagen propeptides. The order of inhibitory potency of the three glucocorticoids on collagen synthesis was hydrocortisone < hydrocortisone-17-butyrate < betamethasone. Thus, assay of collagen propeptides from suction blisters can be used to screen various steroids with respect to their action on collagen synthesis.
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