Background: Tretinoin is a kind of vitamin A derivatives. It is a
kind of topical preparation commonly used to treat acne vulgaris, fine
lines, age spots and other visible signs of ageing. Tretinoin when used
in combination with topical minoxidil is also a well known treatment for
hair loss in both men and women.
all-trans-retinoic acid (tretinoin) alone and in combination with 0.5%
minoxidil has been tested for the promotion of hair growth in 56
subjects with androgenetic alopecia. After 1 year, the combination of
topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth
in 66% of the subjects studied. Tretinoin was shown to stimulate some
hair regrowth in approximately 58% of the subjects studied. One female
subject with pronounced alopecia for more than 20 years had regrowth of
hair using only tretinoin for a period of 18 months. Tretinoin has been
shown to promote and regulate cell proliferation and differentiation in
the epithelium and may promote vascular proliferation. These factors are
important for hair growth promotion. These preliminary results indicate
that more work should be done on the role of retinoids in hair growth.
The synergistic effect of retinoids in combination with a low
concentration of minoxidil should also be further investigated.
Dr Adam Lewenberg treated 484 people with a mixture of topical minoxidil and tretinoin. After two years of treatment "cosmetically satisfying" results were obtained in about 90% of these people. In an article written by Dr Lewenberg about his studies, Dr Lewenberg noted the following: "Unlike Minoxidil which effects on the vertex of the scalp, the combination of Tretinoin and Minoxidil results in hair growth in all regions of the scalp."
Remox Study The Author of this study wished to confirm the
efficacy of ReMox(a combination Of Tretinoin and Minoxidil ) as a
stimulant for hair re growth ,increase in hair volume And tensile
strength of individual hairs in cases of alopecia androgenetica(AGA).
Although the mechanisms of follicular regression in androgenetic alopecia are not fully understood, retinoids may be important in changing the status of regressing follicles. There are many reports documenting reversal of epithelial dysplastic changes with retinoids. Although none of the studies with retinoids have concentrated on the precise mechanisms of follicular growth (regression or regeneration), these limited observations, and our early studies suggest that further work should be done on the effect retinoids have on the hair follicle during the various growth and regression phases of the follicular life cycle in humans. We propose that certain retinoids increase the rate of hair growth, prolong the anagen phase of the hair cycle, play a role in converting vellus to terminal hairs, and act synergistically with minoxidil to produce more dense hair regrowth from regressing follicles than either compound alone. Larger controlled studies and better methods for assessing hair growth are necessary to support these early results. Other retinoids as well as certain minoxidil analogs should also be studied.
6) Retinol Produces Changes in Skin Similar to Those Produced By Retinoic Acid, But Without Irritation.
increases the thickness of the epidermis, enhances expression of CRABP-II
(cellular retinoic acid binding protein) and CRBP (cellular retinol
binding protein), and causes accumulation of retinyl esters, but does
not increase retinoic acid levels or cause erythema. ROL, vitamin A1, is
the predominant retinoid in circulation. Clinically, topical application
of RA has been used for many skin abnormalities, including acne and
photodamaged skin, but its application produces mild erythema and
stratum corneum peeling. A retinoid with activity similar to RA but
without the local irritation would be of interest. In the U.S., ROL has
been widely used in cosmetics and considered safe and is thought to be
the prohormone of RA, in that RA is formed from ROL by a two-step
enzymatic process. Thus, Kang and colleagues asked whether ROL could
achieve RA-like effects in skin. They used a patch-test procedure that
involved four days of occlusion after topical application of ROL and of
RA. They found that ROL may be a good substitute for RA because it was
much less erythemogenic than RA, produced epidermal hyperplasia,
increased the expression of both cellular retinoic acid binding protein
(CRABP-II) and cellular retinol binding protein (CRBP) mRNAs and
proteins, and was actively metabolized and stored as retinyl ester, but
did not result in significant accumulation of RA.
Retin-A is a prescription drug used for the treatment of several skin conditions. It is one of the most effective drugs in the treatment of acne. Clinical trials showed a side effect of some hair regrowth. Many doctors claim that when used in conjunction with Rogaine/Minoxidil, it increases the effectiveness over minoxidil alone 10% or more. One of the ways Retin-A works is by ensuring proper functioning of the sebaceous glands. The sebaceous glands produce sebum on the scalp. Sebum contains DHT which is then reabsorbed into the hair follicles to do further damage. Proper moderation of the sebaceous glands and their production of sebum can help control skin scalp DHT levels, preventing androgen related hair loss. Retin-A also functions to promote cell growth and ensure the proper functioning of other parts of skin cells.
8) Treatments for androgenetic alopecia and alopecia areata: current options and future prospects. Meidan VM, Touitou E. Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
disorders of the hair follicle which may heavily influence self esteem
and self image. Androgenetic alopecia is caused by the heightened
sensitivity of scalp follicles to dihydro- testosterone whereas alopecia
areata is induced by an autoimmune reaction. Current drug treatment
approaches include the use of regrowth stimulators such as topical
minoxidil and oral finasteride for androgenetic alopecia, as well as
topical minoxidil, dithranol (anthralin), corticosteroids, contact
sensitisers, and psoralen plus ultraviolet A irradiation (PUVA) therapy
for alopecia areata. Combination regimens are also proposed. However,
extreme cases of either type of alopecia do not generally respond well
to these existing treatments. For this reason, new therapeutic
strategies are directed towards both improving the targeting of existing
agents, as well as the development of novel hypertrichotic modalities.
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