Hair Loss

georgex6 GREECE ATHENS, 25.06.2012, 04:32	Cotsarelis interview about pgd2 (Hair Loss Research & Clinical Trials)
	www.aad.org/dermatology-world/monthly-archives/2012/june/can-blocking-pgd2-prevent-androgenetic-alopecia- georgex6 is located in GREECE ATHENS and he is available to meet: NO Post reply
action_reaction 25.06.2012, 13:46 @ georgex6	Cotsarelis interview about pgd2
	» www.aad.org/dermatology-world/monthly-archives/2012/june/can-blocking-pgd2-prevent-androgenetic-alopecia- what an idiot that cotsarelis guy is... doesn't know if it will work on women or will it give a full regrowth. Even I know the answers to those questions but at least I didn't spend decades learning this $hit action_reaction is located in [NA] and he is available to meet: NO Post reply
Bob Sakamano 25.06.2012, 20:10 @ action_reaction	Cotsarelis interview about pgd2
	» » » www.aad.org/dermatology-world/monthly-archives/2012/june/can-blocking-pgd2-prevent-androgenetic-alopecia- » » what an idiot that cotsarelis guy is... doesn't know if it will work on » women or will it give a full regrowth. Even I know the answers to those » questions but at least I didn't spend decades learning this $hit huh, you gotta be kidding. He's a medical doctor, educated thru UPENN, a very highly respected University and proceeded to study the field for the past 25 years...and HE's the idiot and you're the smart guy????? Tell me oh genius, what's the answer to the question then. I expect a well thought-out response with studies and experiments (citations included of course) to back up your claims. We should only wish there were more Cotsarelis' out there. I don't know what's worse now: losing my hair or being lumped into the "guys losing their hair" group with the abundances of doosh-bags (sp) who frequent these forums. Bob Sakamano is located in [NA] and he is available to meet: NO Post reply
action_reaction 25.06.2012, 20:17 @ Bob Sakamano	Cotsarelis interview about pgd2
	why the fk then his responses were so stupid? How much hair knowledge you need to know that the same prostaglandins are responsible for hair growth in both men and women? If he's smart, then he's pretending to be dumb for us. It doesn't take 25 years to figure out what's what action_reaction is located in [NA] and he is available to meet: NO Post reply
hairman2 25.06.2012, 20:30 @ action_reaction	Cotsarelis interview about pgd2
	» How much hair knowledge you need to know that the same prostaglandins » are responsible for hair growth in both men and women? what the hell are you talking about. You are speculating that it is the same for women and men. In science nothing is true until it is proven through experimentation... the answer he gave was the only accurate answer he could give as he has not investigated it. » It doesn't take 25 » years to figure out what's what well then i dont understand why you dont start your own research if you are so smart? Apart from regaining your hair you will be rich too... what are you waiting for, genius? hairman2 is located in [NA] and he is available to meet: NO Post reply
jarjarbinx 25.06.2012, 20:55 @ georgex6	Hey, I was right about something (and it's probably important too)
	Here is an excerpt from the article: "There was a mouse that was made in the ’90s by Sue Fisher, who studies skin cancer; it’s a transgenic mouse that makes the COX-2 enzyme in the skin, so you drive COX-2 gene expression with keratin K14 promoters. It’s up higher in the pathway so if you overexpress COX-2 you get increases in PGD2 and also PGE2. E2 and F2 are actually known to promote hair growth — bimatoprost (Latisse) is an F2 analog. We looked at levels of D2 in that mouse, which develops alopecia, and they were sky high. E2 was also higher than the control but D2 levels were much higher. What’s amazing is if you looked at that mouse’s skin histologically the hair follicles were miniaturized and the sebaceous glands were enlarged, just like in androgenetic alopecia" The researcher is saying that Bimatoprost works on a different postaglandin than a PGD2 antagonist works on AND the researcher is saying that the postaglandin that bimatoprost works on is actually a postaglandin that causes hair growth. So that means I was right when I said that it would be a good idea to use a PGD2 antagonist first and a few hours later apply bimatoprost. You see, you apply the PGD2 antagonist to negate PGD2 and its' derivative(s) which take hair from you and you also apply bimatoprost which grows hair. It's like a double-whammy attack against baldness. jarjarbinx is located in [NA] and he is available to meet: NO Post reply
jarjarbinx 25.06.2012, 21:01 @ action_reaction	Cotsarelis interview about pgd2
	» » » www.aad.org/dermatology-world/monthly-archives/2012/june/can-blocking-pgd2-prevent-androgenetic-alopecia- » » what an idiot that cotsarelis guy is... doesn't know if it will work on » women or will it give a full regrowth. Even I know the answers to those » questions but at least I didn't spend decades learning this $hit Action what about the effects that androgens (DHT and its' cousins like testosterone) have on hair? They take hair from us as well. You can wipe out all of the postaglandins that cause hair loss and activate all of the postagalnding that cause hair growth but that still won't solve the androgen (dht and its' cousins) problem. This is why my excitement about the PGD2 discovery is tempered - i worry that even with a PGD2 antagonist the androgens will still keep the hair growth door from opening. jarjarbinx is located in [NA] and he is available to meet: NO Post reply
Rudy 26.06.2012, 16:55 @ jarjarbinx	Hey, I was right about something (and it's probably important too)
	» Here is an excerpt from the article: » » » "There was a mouse that was made in the ’90s by Sue Fisher, who » studies skin cancer; it’s a transgenic mouse that makes the COX-2 enzyme in » the skin, so you drive COX-2 gene expression with keratin K14 promoters. » It’s up higher in the pathway so if you overexpress COX-2 you get increases » in PGD2 and also PGE2. E2 and F2 are actually known to promote » hair growth — bimatoprost (Latisse) is an F2 analog. We looked at » levels of D2 in that mouse, which develops alopecia, and they were sky » high. E2 was also higher than the control but D2 levels were much higher. » What’s amazing is if you looked at that mouse’s skin histologically the » hair follicles were miniaturized and the sebaceous glands were enlarged, » just like in androgenetic alopecia" » » » The researcher is saying that Bimatoprost works on a different postaglandin » than a PGD2 antagonist works on AND the researcher is saying that the » postaglandin that bimatoprost works on is actually a postaglandin that » causes hair growth. So that means I was right when I said that it would be » a good idea to use a PGD2 antagonist first and a few hours later apply » bimatoprost. You see, you apply the PGD2 antagonist to negate PGD2 and » its' derivative(s) which take hair from you and you also apply bimatoprost » which grows hair. It's like a double-whammy attack against baldness. Yeah,I agree with you. I just said that in another post after studying a bit more about prostaglandins and bimatoprost . Mast cell stabilizer to stop PGD2 and then bimatoprost. My question is are there other cells that release PGD2 besides mast cells. I know alomost all types of cells are capable of producing prostaglandins but mast cells are the cells most associated with pro inflammatory responses and PGD2 being a prostaglandin that causes inflammation, is it only secreted by mast cells? Even if other cells can produce PGD2 i have a feeling that the majority of PGD2 in scalp is caused by mast cells and stabilizing them could bring the ratio in order to non balding scalp. Rudy is located in [NA] and he is available to meet: NO Post reply