Hair Loss Forum - Fgf9
instant hair thickening fibers scalp pigmentation tattoo

Log in | User | Register

Thread view  Order  «  
 

featured hair transplant results & topics
free hair transplant consultations in London, Los Angeles, New York, and cities worldwide

-Dr. Baubac (Alvi Armani) latest patient results 3115 grafts.
-Hasson & Wong: 4050 grafts, 1 year, strip.
-Hairman2's 2500 grafts FUE at HDC Cyprus.

-Dr. Arvind taking Scalp Micro Pigmentation to the test.
-Dr. Ray Woods: world's 1st FUE + BHT scar repair!

-Dr. Umar's UGraft: find out why it is superior.
-Dr. Bisanga 2924 grafts FUE, 8 months.
-Dr. Arvind presentations at ISHRS & AAHRS conference.
-Dr. Baubac (Alvi Armani): redefining the best in artistry.

-Dr. Jones: 6000 grafts FUE megasession, 4 months.

mell

02.06.2013, 13:19
 

Fgf9 (Hair Multiplication & Stem Cells Treatment)

http://medicalxpress.com/news/2013-06-growth-factor-responsible-triggering-hair.html

The findings help explain why humans don't regenerate their hair after wounding," said senior author George Cotsarelis, MD, professor and chair of Dermatology. "The study also points us to a way to treat wounds and grow hair." Following up on earlier work, which showed that increased signaling from the Wnt pathway doubled the number of new hair follicles, the Penn team looked further upstream in the pathway and identified an important cascade of signals that prompt further expression, as well as perpetuate and amplify signals sent during a crucial phase of hair-follicle regeneration. Fgf9 is initially secreted from gamma delta T cells, an unconventional, rare subset of T cells involved in the immune response. Once released, Fgf9 serves as the catalyst for a signal sent via the dermal Wnt pathway. The signal prompts further expression of Fgf9 in structural cells called fibroblasts, and adds to the generation of new hair follicles. When a wound occurs in an adult person, hair follicle growth is blocked and the skin heals with a scar. However, hair does regenerate to a great extent in the wound-healing process in mice. The team compared how the process works in adult mice versus humans. Humans have low numbers of gamma delta T cells in their skin compared to mice, and this may explain why human skin scars but does not regenerate hair follicles. In adult mice, the amount of Fgf9 secreted modulates hair-follicle regeneration after wounding. When Fgf9 was reduced, there was a decrease in wound-induced hair follicle growth. Conversely, when Fgf9 was increased, there was a two- to three-fold increase in the number of new hair follicles, equal to the amount seen in the mice expressing Wnt. Importantly, when the investigators added Fgf9 back to the wounds that do not normally regenerate, FGF9 triggered the molecular cascade of events necessary for skin and hair regeneration; thus, leaving the door open for using Fgf9 to treat wounds and hair loss in people. The Penn team suggests that, given the differences in skin development and regeneration in response to wounding, treatments intended to compensate for the lack of Fgf9 may be most effective if timed with a wounding response. "Testing activators of Fgf9 or Wnt pathways during the wound healing process may be warranted," they stated.

Read more at: http://medicalxpress.com/news/2013-06-growth-factor-responsible-triggering-hair.html#jCp




mell is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

02.06.2013, 13:29

@ mell

Fgf9

Could we overcome this obstacle by simply injecting growth factors and Wnts rather than trying to create them via wounding?


Originally Posted by mell

http://medicalxpress.com/news/2013-06-growth-factor-responsible-triggering-hair.html

The findings help explain why humans don't regenerate their hair after wounding," said senior author George Cotsarelis, MD, professor and chair of Dermatology. "The study also points us to a way to treat wounds and grow hair." Following up on earlier work, which showed that increased signaling from the Wnt pathway doubled the number of new hair follicles, the Penn team looked further upstream in the pathway and identified an important cascade of signals that prompt further expression, as well as perpetuate and amplify signals sent during a crucial phase of hair-follicle regeneration. Fgf9 is initially secreted from gamma delta T cells, an unconventional, rare subset of T cells involved in the immune response. Once released, Fgf9 serves as the catalyst for a signal sent via the dermal Wnt pathway. The signal prompts further expression of Fgf9 in structural cells called fibroblasts, and adds to the generation of new hair follicles. When a wound occurs in an adult person, hair follicle growth is blocked and the skin heals with a scar. However, hair does regenerate to a great extent in the wound-healing process in mice. The team compared how the process works in adult mice versus humans. Humans have low numbers of gamma delta T cells in their skin compared to mice, and this may explain why human skin scars but does not regenerate hair follicles. In adult mice, the amount of Fgf9 secreted modulates hair-follicle regeneration after wounding. When Fgf9 was reduced, there was a decrease in wound-induced hair follicle growth. Conversely, when Fgf9 was increased, there was a two- to three-fold increase in the number of new hair follicles, equal to the amount seen in the mice expressing Wnt. Importantly, when the investigators added Fgf9 back to the wounds that do not normally regenerate, FGF9 triggered the molecular cascade of events necessary for skin and hair regeneration; thus, leaving the door open for using Fgf9 to treat wounds and hair loss in people. The Penn team suggests that, given the differences in skin development and regeneration in response to wounding, treatments intended to compensate for the lack of Fgf9 may be most effective if timed with a wounding response. "Testing activators of Fgf9 or Wnt pathways during the wound healing process may be warranted," they stated.

Read more at: http://medicalxpress.com/news/2013-06-growth-factor-responsible-triggering-hair.html#jCp[/div]




jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
shivers20

02.06.2013, 15:43

@ mell

Fgf9

Doesnt Pge2 induce Fgf9?




shivers20 is located in [NA] and he is available to meet: NO


Post reply
Z79

02.06.2013, 16:03

@ mell

Fgf9

This pisses me off. I have been waiting for this article go get published for many years. Back in 2010 cotsarelis got a patent for exactly this "New" Discovery. He sits on his breakthroughs for years and when he needs some New funding he publishes them. Same thing with his pgd2 finding. No wonder science Move so slow with that attitude.




Z79 is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

02.06.2013, 16:32

@ Z79

Fgf9

Ok so then if you're saying that Cots is is using this info-release as an attempt to get more money from someone who is he trying to get more money from? As far as I know this info would only be relevant to Follica.

Please explain??? Who is he trying to get money from?



Originally Posted by Z79

This pisses me off. I have been waiting for this article go get published for many years. Back in 2010 cotsarelis got a patent for exactly this "New" Discovery. He sits on his breakthroughs for years and when he needs some New funding he publishes them. Same thing with his pgd2 finding. No wonder science Move so slow with that attitude.





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
Z79

02.06.2013, 16:51

@ jarjarbinx

Fgf9

His lab doesnt get all the money from the university but need funding from external resources. My point was that cots clearly uses his scientific findings with a career driven motive and not for the sake of bringing new knowledge to humanity. Nothing wrong with that but I personally find it annoying and it slows down new Discoveries based on his findings.




Z79 is located in [NA] and he is available to meet: NO


Post reply
KO

02.06.2013, 17:17

@ Z79

Fgf9

What career driven motive? The guy is a high level dermatologist at one of the world's best schools holding an endowed chair in the field. His job is secure for the rest of his life and he will make a very good salary even if he does NOTHING for the rest of his life. Secondly, the IP he develops belongs to UPenn.


Furthermore, other scholars could have looked at his research and continued with his findings...but who else is there?




KO is located in [NA] and he is available to meet: NO


Post reply
shivers20

02.06.2013, 19:46

@ Z79

Fgf9

I would be more concerned with Cots not having any new patents.
There is a 4 year wait between all his recent patents and results. Pgd2 discovery took four years and now fgf9




shivers20 is located in [NA] and he is available to meet: NO


Post reply
Khalil

02.06.2013, 19:58

@ shivers20

Fgf9

Link to the Nature Article

http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3181.html




Khalil is located in [NA] and he is available to meet: NO


Post reply
HairlossCurse

02.06.2013, 20:35

@ Khalil

Fgf9

Recieved 1st of January but not published until now, how long does it take to process a paper?? Nevermind that at least he is continuing his research this paper was done only 7 months after his pdg2 paper so he is not slowing down.

Although I think this research is more driven based off scarring types of hairloss - which require whole new follicles using wound healing etc. Cots research interests are "alopecia" not "androgenetic alopecia".




HairlossCurse is located in [NA] and he is available to meet: NO


Post reply
superhl

02.06.2013, 23:20

@ HairlossCurse

Fgf9

Here why it take so long.... "The importance of Fgf9 in hair follicle regeneration SUGGESTS that it could be used therapeutically in humans.". If they could just test on humans and not some useless mouse!!!!!!




superhl is located in [NA] and he is available to meet: NO


Post reply
superhl

03.06.2013, 09:53

@ superhl

another story

http://www.marketwatch.com/story/new-study-identifies-the-role-of-a-key-growth-factor-in-promoting-formation-of-hair-follicles-and-suggests-a-new-therapeutic-approach-to-treat-baldness-2013-06-03




superhl is located in [NA] and he is available to meet: NO


Post reply
alecbaldone

03.06.2013, 10:41

@ superhl

another story

well, this is our new target




alecbaldone is located in [NA] and he is available to meet: NO


Post reply
superhl

03.06.2013, 11:52

@ alecbaldone

another story

It appears they have tested on humans. This could the real deal!!
http://www.xconomy.com/boston/2013/06/03/hair-raising-follica-study-could-point-to-baldness-therapy/




superhl is located in [NA] and he is available to meet: NO


Post reply
appleguy

03.06.2013, 12:29

@ superhl

another story

Just as Histogen lands with a thud. He giveth and he taketh away.

It would be crazy ironic for the one company we had written off had all this time the real cure.
Could be interesting but wouldn't want to get all Histogen excited again. Need some real results this time. I'd be interested to see what Dr. Nigam makes of this.




appleguy is located in [NA] and he is available to meet: NO


Post reply
Jackson24

03.06.2013, 12:57

@ appleguy

another story

Sorry for my perhaps stupid quastion, but my english is not so good...does this finding anything do with pgd2? Because i saw that Cots is in the team and i'am wondering if this has anything do with his study about pgd2 or has he written the pgd2 thing off? Sorry again for my stupid quastion...




Jackson24 is located in [NA] and he is available to meet: NO


Post reply
oppenheimer82

03.06.2013, 17:34

@ superhl

Fgf9

they already tested this on the scalp of human beings. this is huge, very huge. but i don't understand why dr cots didn't mention one thing about this during the meeting in Edinburgh.




oppenheimer82 is located in [NA] and he is available to meet: NO


Post reply
oppenheimer82

03.06.2013, 17:37

@ appleguy

another story

yes! this was my first thought as well. i don't seem to remember that dr nigam was using fgf9 in his hm and doubling treatments. other growth factors, yes, but not this particular one.




oppenheimer82 is located in [NA] and he is available to meet: NO


Post reply
Khalil

03.06.2013, 17:49

@ oppenheimer82

Dr. Cotsarelis New Discovery that may finally cure Baldness (June 3rd, 2013)

http://www.xconomy.com/boston/2013/0...dness-therapy/

http://www.sciencedaily.com/releases...0602144327.htm


I think this is the real deal. Fingers crossed!




Khalil is located in [NA] and he is available to meet: NO


Post reply
hairman2

03.06.2013, 17:59
(edited by hairman2, 03.06.2013, 18:17)

@ Khalil

Dr. Cotsarelis New Discovery that may finally cure Baldness (June 3rd, 2013)

your links were broken

http://www.xconomy.com/boston/2013/06/03/hair-raising-follica-study-could-point-to-baldness-therapy/

http://www.sciencedaily.com/releases/2013/06/130602144327.htm




hairman2 is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

03.06.2013, 18:12

@ oppenheimer82

another story

Oppenheimer do you think fgf9 would work with injected growth factors or do you think that fgf9 would only work in connection with wounding?




jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
hairman2

03.06.2013, 18:19

@ jarjarbinx

another story

certainly only with wounding. It appears that fgf9 takes advantage of a small time window in which skin cells are in a healing stage, which closely resembles an embryonic stage and triggers the skin cells to form new follicles during that period.

In other words treatment with fgf9 is timed with the wounding phase.

Originally Posted by jarjarbinx

Oppenheimer do you think fgf9 would work with injected growth factors or do you think that fgf9 would only work in connection with wounding?





hairman2 is located in [NA] and he is available to meet: NO


Post reply
KO

03.06.2013, 18:29

@ oppenheimer82

Fgf9

This is not correct, they have not tested this on human scalp.

What this suggests is that Follica may not be dead yet. Note that the people commenting are Bernat Olle and William Ju, whom were not involved in the study.




KO is located in [NA] and he is available to meet: NO


Post reply
shivers20

03.06.2013, 18:29

@ jarjarbinx

Fgf9

Injecting this growth factor isnt going to do anything without epidermal disruption. The whole process is to create NEW follicles. Where are the old timers on this site who were experimenting with chemical peels and EGFR inhibitors? We didnt know about pgd2 as an inhibitor and now Fgf as a growth agent in WIHN. They had the right idea. Refer back to the Benaxoprofen/Sulfasalazine cases where they grew hair in balding areas. Chemical peels can be
tested on a small area of the arm or leg, application of Fgf9, Pge2, and pgd2 inhibitor. This has to timed correctly. Follow the Follica patent.




shivers20 is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

03.06.2013, 18:33

@ hairman2

another story

That's the way it looks to me too.

Although I admit that I have a very tiny bit of curiousity to see what would happen if the histogen growth factors were injected as part of a treatment with fgf9 with no wounding.



certainly only with wounding. It appears that fgf9 takes advantage of a small time window in which skin cells are in a healing stage, which closely resembles an embryonic stage and triggers the skin cells to form new follicles during that period.

In other words treatment with fgf9 is timed with the wounding phase.

Originally Posted by jarjarbinx

Oppenheimer do you think fgf9 would work with injected growth factors or do you think that fgf9 would only work in connection with wounding?

Originally Posted by hairman2





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

03.06.2013, 19:05

@ shivers20

Fgf9

I think you're probably right, but I'm not 100% sure.

Also, even if fgf9 works by wounding only I can't imagine that adding Wnts and other growth factors would reduce the efficacy of fgf9. It seems to me that adding Wnts and growth factor could possibly help fgf9 produce even better results.

But this is just a guess.


Originally Posted by shivers20

Injecting this growth factor isnt going to do anything without epidermal disruption. The whole process is to create NEW follicles. Where are the old timers on this site who were experimenting with chemical peels and EGFR inhibitors? We didnt know about pgd2 as an inhibitor and now Fgf as a growth agent in WIHN. They had the right idea. Refer back to the Benaxoprofen/Sulfasalazine cases where they grew hair in balding areas. Chemical peels can be
tested on a small area of the arm or leg, application of Fgf9, Pge2, and pgd2 inhibitor. This has to timed correctly. Follow the Follica patent.





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

03.06.2013, 19:21

@ shivers20

Fgf9

Does wounding result in full reversal of hairloss in mice or does it require wounding plus other things to achieve full regrowth in mice?


Originally Posted by shivers20

Injecting this growth factor isnt going to do anything without epidermal disruption. The whole process is to create NEW follicles. Where are the old timers on this site who were experimenting with chemical peels and EGFR inhibitors? We didnt know about pgd2 as an inhibitor and now Fgf as a growth agent in WIHN. They had the right idea. Refer back to the Benaxoprofen/Sulfasalazine cases where they grew hair in balding areas. Chemical peels can be
tested on a small area of the arm or leg, application of Fgf9, Pge2, and pgd2 inhibitor. This has to timed correctly. Follow the Follica patent.





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
Khalil

03.06.2013, 19:39

@ jarjarbinx

Fgf9

According to the article mice naturally have elevated levels of Fgf9 in their skin, which explains why they regenerate new hairs after wounding.

Humans on the other hand have significantly less Fgf9 in our skin, and explains why we have trouble forming new hairs after wounding.

So basically we need to externally add Fgf9 during the wounding process to create new hairs.




Khalil is located in [NA] and he is available to meet: NO


Post reply
shivers20

03.06.2013, 21:01

@ jarjarbinx

Fgf9

There is a possibility that Fgf9 without epidermal disruption could lead to epidermal thickening.

http://www.google.com/patents?hl=en&lr=&vid=USPATAPP13129100&id=41z9AQAAEBAJ&oi=fnd&dq=fgf9+wound+induced+hair+follicle&printsec=abstract#v=onepage&q=fgf9%20wound%20induced%20hair%20follicle&f=false




shivers20 is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

03.06.2013, 21:54

@ shivers20

Fgf9

Your link doesn't prove evidence that fgf9 without epidermal disruption could lead to epidermal thickening. What are you basing this on?


Originally Posted by shivers20

There is a possibility that Fgf9 without epidermal disruption could lead to epidermal thickening.

http://www.google.com/patents?hl=en&lr=&vid=USPATAPP13129100&id=41z9AQAAEBAJ&oi=fnd&dq=fgf9+wound+induced+hair+follicle&printsec=abstract#v=onepage&q=fgf9%20wound%20induced%20hair%20follicle&f=false[/div]




jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
superhl

03.06.2013, 22:13

@ jarjarbinx

Fgf9

I tried the wounding process with lithium when the study came out. No results. I wonder what happen to Benji. He was very knowledgeable about the patent. I would love to try it again. Wonder what chemicals we need and when to apply them. I don't remember the exact steps. Benji are you still around???




superhl is located in [NA] and he is available to meet: NO


Post reply
ESP3

03.06.2013, 22:14

@ shivers20

Fgf9

Good observation. Some members were experimenting with the skin wounding/growth factor combination (getfitinb, or something like that--a very expensive cancer treatment drug if memory serves) a while back, but I wonder whether they ever figured out the precise window of time to apply the growth factor, and the extent/depth of wounding required. I think some people were using sandpaper, others a derma roller.

Also, I remember reading a story about a bald guy who was sunburned on his scalp while taking medication (don't ask me what) who miraculously re-grew a significant amount of hair. this story preceeded the wounding GF phenomenon era of this board...




ESP3 is located in [NA] and he is available to meet: NO


Post reply
hairman2

04.06.2013, 03:56

@ jarjarbinx

Fgf9

Well, it seems fgf9 is upstream of WNT

[source http://www.sciencedaily.com/releases/2013/06/130602144327.htm ]

Following up on earlier work, which showed that increased signaling from the Wnt pathway doubled the number of new hair follicles, the Penn team looked further upstream in the pathway and identified an important cascade of signals that prompt further expression, as well as perpetuate and amplify signals sent during a crucial phase of hair-follicle regeneration.


I think you're probably right, but I'm not 100% sure.

Also, even if fgf9 works by wounding only I can't imagine that adding Wnts and other growth factors would reduce the efficacy of fgf9. It seems to me that adding Wnts and growth factor could possibly help fgf9 produce even better results.

But this is just a guess.


Originally Posted by shivers20

Injecting this growth factor isnt going to do anything without epidermal disruption. The whole process is to create NEW follicles. Where are the old timers on this site who were experimenting with chemical peels and EGFR inhibitors? We didnt know about pgd2 as an inhibitor and now Fgf as a growth agent in WIHN. They had the right idea. Refer back to the Benaxoprofen/Sulfasalazine cases where they grew hair in balding areas. Chemical peels can be
tested on a small area of the arm or leg, application of Fgf9, Pge2, and pgd2 inhibitor. This has to timed correctly. Follow the Follica patent.

Originally Posted by jarjarbinx





hairman2 is located in [NA] and he is available to meet: NO


Post reply
hairman2

04.06.2013, 03:59

@ jarjarbinx

Fgf9

The way I understand it fgf9 is downstream of WNT, which means


I think you're probably right, but I'm not 100% sure.

Also, even if fgf9 works by wounding only I can't imagine that adding Wnts and other growth factors would reduce the efficacy of fgf9. It seems to me that adding Wnts and growth factor could possibly help fgf9 produce even better results.


Originally Posted by shivers20

Injecting this growth factor isnt going to do anything without epidermal disruption. The whole process is to create NEW follicles. Where are the old timers on this site who were experimenting with chemical peels and EGFR inhibitors? We didnt know about pgd2 as an inhibitor and now Fgf as a growth agent in WIHN. They had the right idea. Refer back to the Benaxoprofen/Sulfasalazine cases where they grew hair in balding areas. Chemical peels can be
tested on a small area of the arm or leg, application of Fgf9, Pge2, and pgd2 inhibitor. This has to timed correctly. Follow the Follica patent.

Originally Posted by jarjarbinx





hairman2 is located in [NA] and he is available to meet: NO


Post reply
oppenheimer82

04.06.2013, 04:11

@ superhl

Fgf9

you need something that mimicks fgf9.




oppenheimer82 is located in [NA] and he is available to meet: NO


Post reply
oppenheimer82

04.06.2013, 04:12

@ jarjarbinx

another story

hairman 2 is correct in his observation. this is major guys, major.




oppenheimer82 is located in [NA] and he is available to meet: NO


Post reply
oppenheimer82

04.06.2013, 04:15

@ KO

Fgf9

yes, they have. " The company has run a series of human clinical trials, including a Phase IIa trial, which have demonstrated follicular neogenesis in humans for the first time."

[source]http://www.prnewswire.com/news-releases/new-study-identifies-the-role-of-a-key-growth-factor-in-promoting-formation-of-hair-follicles-and-suggests-a-new-therapeutic-approach-to-treat-baldness-209914441.html




oppenheimer82 is located in [NA] and he is available to meet: NO


Post reply
shivers20

04.06.2013, 04:50
(edited by shivers20, 04.06.2013, 05:26)

@ oppenheimer82

Fgf9

The drug that they are talking about might be Valproic Acid? There is a patent for FGF-9 to treat anxiety disorders. VPA similar to lithium and is involved in morphogenesis via gsk inhibition




shivers20 is located in [NA] and he is available to meet: NO


Post reply
dcssalman

04.06.2013, 07:31

@ mell

Fgf9

Never seen this kinda massive information before thanks for the post




dcssalman is located in [NA] and he is available to meet: NO


Post reply
georgex6

GREECE ATHENS,
04.06.2013, 16:39

@ dcssalman

Fgf9

any guinea pig to test it :-)
http://www.prospecbio.com/FGF9_Human_2/?gclid=CLHNxYOgy7cCFYdd3godVxoADA




georgex6 is located in GREECE ATHENS and he is available to meet: NO


Post reply
alecbaldone

04.06.2013, 16:55

@ georgex6

Fgf9

good find George




alecbaldone is located in [NA] and he is available to meet: NO


Post reply
shivers20

04.06.2013, 17:00

@ georgex6

Fgf9

Sounds like they aren't using straight up FGF-9, another drugs, my guess is lithium, egfr inhbitor or VPA. This is very exciting if it pans out, it can possibly be a procedure done at home. I have searching for any clinical trials but havent come across any, they are def keeping a low profile. Interiew from 2008,

PureTech put together a team of expert advisors to begin looking at different aspects of aesthetic medicine. Their survey spanned everything from skin rejuvenation approaches to fat melting techniques, perhaps more than 100 different ideas in all, Zohar says. “As we were looking, we noticed the most interesting things had something to do with the follicle,” she says. “The follicle’s almost like the epicenter of human hair and skin.” If you can control the follicles and the sebaceous glands that are connected to each of them, you can theoretically create new hair, stop hair from growing, or even treat acne, Zohar says. “Whatever you do to the follicle is going to be beneficial to somebody,” she adds.

Armed with that realization, PureTech put together an even smaller group of follicle experts—Price, Anderson, and Cotsarelis formed the core of this contingent—to study possible research or technological approaches to follicular problems in more detail.

Then, one day, Cotsarelis told Zohar he was working on something in his lab that could be just what the doctor ordered. The Penn scientist was persuaded to bring that work to Follica, which eventually licensed Cotsarelis’s core research.

Cotsarelis, an expert in epithelial stem cells such as those found in the skin, was studying how skin heals and noticed that new hair follicles seemed to be forming in the middle of some of some wounds. He learned that when the skin’s top layers were removed, some cells within the wound revert to a more primitive state (what he calls an “embryonic window”) from which they can develop into either hair or skin. With more research, says Zohar, Cotsarelis found that he “could actually push them to one direction or another.” In a widely read Nature paper published last May, Cotsarelis showed for the first time that it’s possible to create new hair follicles in adult mammals—and to shut down hair growth. He could even grow thicker, darker hair.

Zohar says Follica has further developed this work and filed additional patents to protect the technology. What’s so beautiful about the approach, she says, is that translating it into a treatment for humans involves only devices and drugs that are already on the market. A doctor would first use a microdermabrasion tool, say, or a laser to remove the top layers of the skin—as is already commonly done in a number of dermatologic and cosmetic procedures—knocking some cells back into a primitive state. The doctor can then use this newly created therapeutic window to inject drugs that push the cells to develop along one pathway or another and grow hair or skin. Zohar won’t reveal what drugs Follica is using, except to say that they are small molecule drugs normally taken orally for purposes with no relation to hair growth.

Because the components of the system are already approved, the regulatory path is pretty straightforward, and Follica can perform human studies without jumping through a lot of governmental hoops. That’s exactly what the company plans to do with the money it has just raised. A proof of concept study involving 15 to 20 patients (Follica has no shortage of volunteers, as several hundred people sent in e-mails when word of Cotsarelis’s work reached the public) should begin in the next few months. The trial has several phases, however, and Zohar cautions that final data won’t be in for at least a year. So don’t pull your hair out waiting for results.




shivers20 is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

04.06.2013, 17:53

@ shivers20

Fgf9

Shivers I wonder what would happen if we combined Histogen-like growth factors and Wnt7 and Wnt10b along with FGF9 and cultured hair cells. What do you think?

Doesn't this sound like it has a lot of potential?





Originally Posted by shivers20

Sounds like they aren't using straight up FGF-9, another drugs, my guess is lithium, egfr inhbitor or VPA. This is very exciting if it pans out, it can possibly be a procedure done at home. I have searching for any clinical trials but havent come across any, they are def keeping a low profile. Interiew from 2008,

PureTech put together a team of expert advisors to begin looking at different aspects of aesthetic medicine. Their survey spanned everything from skin rejuvenation approaches to fat melting techniques, perhaps more than 100 different ideas in all, Zohar says. “As we were looking, we noticed the most interesting things had something to do with the follicle,” she says. “The follicle’s almost like the epicenter of human hair and skin.” If you can control the follicles and the sebaceous glands that are connected to each of them, you can theoretically create new hair, stop hair from growing, or even treat acne, Zohar says. “Whatever you do to the follicle is going to be beneficial to somebody,” she adds.

Armed with that realization, PureTech put together an even smaller group of follicle experts—Price, Anderson, and Cotsarelis formed the core of this contingent—to study possible research or technological approaches to follicular problems in more detail.

Then, one day, Cotsarelis told Zohar he was working on something in his lab that could be just what the doctor ordered. The Penn scientist was persuaded to bring that work to Follica, which eventually licensed Cotsarelis’s core research.

Cotsarelis, an expert in epithelial stem cells such as those found in the skin, was studying how skin heals and noticed that new hair follicles seemed to be forming in the middle of some of some wounds. He learned that when the skin’s top layers were removed, some cells within the wound revert to a more primitive state (what he calls an “embryonic window”) from which they can develop into either hair or skin. With more research, says Zohar, Cotsarelis found that he “could actually push them to one direction or another.” In a widely read Nature paper published last May, Cotsarelis showed for the first time that it’s possible to create new hair follicles in adult mammals—and to shut down hair growth. He could even grow thicker, darker hair.

Zohar says Follica has further developed this work and filed additional patents to protect the technology. What’s so beautiful about the approach, she says, is that translating it into a treatment for humans involves only devices and drugs that are already on the market. A doctor would first use a microdermabrasion tool, say, or a laser to remove the top layers of the skin—as is already commonly done in a number of dermatologic and cosmetic procedures—knocking some cells back into a primitive state. The doctor can then use this newly created therapeutic window to inject drugs that push the cells to develop along one pathway or another and grow hair or skin. Zohar won’t reveal what drugs Follica is using, except to say that they are small molecule drugs normally taken orally for purposes with no relation to hair growth.

Because the components of the system are already approved, the regulatory path is pretty straightforward, and Follica can perform human studies without jumping through a lot of governmental hoops. That’s exactly what the company plans to do with the money it has just raised. A proof of concept study involving 15 to 20 patients (Follica has no shortage of volunteers, as several hundred people sent in e-mails when word of Cotsarelis’s work reached the public) should begin in the next few months. The trial has several phases, however, and Zohar cautions that final data won’t be in for at least a year. So don’t pull your hair out waiting for results.





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
shivers20

04.06.2013, 18:33
(edited by shivers20, 04.06.2013, 18:52)

@ jarjarbinx

Fgf9

Jar,
Good question. Growth factors timed correctly during the "cascade" can speed up the process of folllicle neogenesis. at the same time you would apply a pgd2 inhibitor. Im guessing of course.

Benji Baccy, you guys still around? These guys were experimenting with this stuff minus the FGF-9 finding of course,

http://www.hairsite.com/hair-loss/board_entry-id-37431-page-0-order-last_answer-category-1.html




shivers20 is located in [NA] and he is available to meet: NO


Post reply
georgex6

GREECE ATHENS,
04.06.2013, 19:06

@ shivers20

Fgf9

correlation between fgf9 & pgd2? ???????
http://www.ncbi.nlm.nih.gov/m/pubmed/19429785/




georgex6 is located in GREECE ATHENS and he is available to meet: NO


Post reply
KO

04.06.2013, 19:18

@ oppenheimer82

Fgf9

Your information is wrong. The only trial they've done is wounding and lithium. Otherwise, please post a link showing what they've done. Not expecting a response from you.

Here is the lithium trial:
https://www.clinicaltrialsregister.eu/ctr-search/trial/2009-018191-34/DE




KO is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

04.06.2013, 19:23

@ shivers20

Fgf9

I'm not 100% sure that we would need to worry about factoring timing for the cascade moment. What does the cascade moment do besides produce growth factors? If all the cascade moment does is produce growth factors perhaps injecting the growth factors = the same thing as the cascade moment. If that's the case then growth factors + FGF9 = the same thing as wounding + FGF9.




jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
hairman2

05.06.2013, 03:26

@ oppenheimer82

Fgf9

sorry oppenheimer82 but after your post regarding how you were going to post pics of your significant regrowth on PGD2 inhibitors and that you were almost in tears because the success was so outstanding, it is hard for me to take anything you say seriously anymore.

To bring up peoples hopes like that only to disappear and never make a mention of it again is very disturbing. In fact I think it is rather shameful.


Originally Posted by oppenheimer82

they already tested this on the scalp of human beings. this is huge, very huge. but i don't understand why dr cots didn't mention one thing about this during the meeting in Edinburgh.





hairman2 is located in [NA] and he is available to meet: NO


Post reply
hairman2

05.06.2013, 03:31

@ jarjarbinx

Fgf9

You really have no idea how complicated biochemistry is. You can rest assured that there is a lot more involved in the healing process of skin than can be summed up in administering a simple HSC growth factor cocktail.

Growth factors shift and change during the different healing phases and there are complex equilibriums invovled which cannot be so easily replicated from without.

I am positive that the healing process is an absolute necessity and truly believe that you have an obvious lack of basic understanding of how complex the processes in human biochemistry actually are.

Originally Posted by jarjarbinx

I'm not 100% sure that we would need to worry about factoring timing for the cascade moment. What does the cascade moment do besides produce growth factors? If all the cascade moment does is produce growth factors perhaps injecting the growth factors = the same thing as the cascade moment. If that's the case then growth factors + FGF9 = the same thing as wounding + FGF9.





hairman2 is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

05.06.2013, 16:07

@ hairman2

Fgf9

Your reasoning is unsound and/or impractical and/or unfounded for a number of reasons:

1. Histogen has proved that growth factor can grow hair despite the moment growth factors appear in the skin.

2. If everything has to be perfect as it is in nature for FGF9 to have the desired effect then it seems to me that you would not be able to bring in external growth factors at all, rather you would have to prompt the cells to produce all of these growth factors instead of just putting the growth factors in to the skin from an external source but Cots's own study showed that FGF9 can be added from an external source.

3. If growth factors have to present at an exact right moment and in an exact correct amount, then even FGF9 has to be produced at an exact right moment and in an exact correct amount. And of course that exact correct amount of FGF9, and possibly the exact timing of the production of FGF9 after a wound would fluctuate from person to person, perhaps from time to time over each person's life, and from wounding event to wounding event. So if you are correct. It would be very difficult to standardize a treatment for the general population if you're correct.

4. Did cots test the effect of adding FGF9 and other key growth factors to the mouse skin to see if it would grow hair without wounding? I don't think so.

And I'll come up with some more reasons.



You really have no idea how complicated biochemistry is. You can rest assured that there is a lot more involved in the healing process of skin than can be summed up in administering a simple HSC growth factor cocktail.

Growth factors shift and change during the different healing phases and there are complex equilibriums invovled which cannot be so easily replicated from without.

I am positive that the healing process is an absolute necessity and truly believe that you have an obvious lack of basic understanding of how complex the processes in human biochemistry actually are.

Originally Posted by jarjarbinx

I'm not 100% sure that we would need to worry about factoring timing for the cascade moment. What does the cascade moment do besides produce growth factors? If all the cascade moment does is produce growth factors perhaps injecting the growth factors = the same thing as the cascade moment. If that's the case then growth factors + FGF9 = the same thing as wounding + FGF9.

Originally Posted by hairman2





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply
jarjarbinx

05.06.2013, 16:13

@ hairman2

Fgf9

What do you base your theory on?

Please provide a link to a study establishing that wounding has to accompany the materialization of FGF9 in order for FGF9 to be effective.

Link please.

And don't provide a link only showing that FGF9 is effective when it materializes at an exact moment after wounding. I already know that. I want to see your proof that FGF9 won't be effective without wounding.



You really have no idea how complicated biochemistry is. You can rest assured that there is a lot more involved in the healing process of skin than can be summed up in administering a simple HSC growth factor cocktail.

Growth factors shift and change during the different healing phases and there are complex equilibriums invovled which cannot be so easily replicated from without.

I am positive that the healing process is an absolute necessity and truly believe that you have an obvious lack of basic understanding of how complex the processes in human biochemistry actually are.

Originally Posted by jarjarbinx

I'm not 100% sure that we would need to worry about factoring timing for the cascade moment. What does the cascade moment do besides produce growth factors? If all the cascade moment does is produce growth factors perhaps injecting the growth factors = the same thing as the cascade moment. If that's the case then growth factors + FGF9 = the same thing as wounding + FGF9.

Originally Posted by hairman2





jarjarbinx is located in [NA] and he is available to meet: NO


Post reply

Thread view  Order  «  
 
116203 Postings in 11125 Threads, 5354 registered users
Hair Loss Forum | Admin contact

 

Disclosure: This is an advertising site for our paid sponsors & advertisers. The contents, videos & photos on HairSite are provided by paid sponsors and are not endorsed by HairSite in any way. The recommendations, results, and representations made by our sponsors/advertisers do not reflect the opinions of HairSite. This site is to showcase successful hair restoration results only. It is not the mandate of this site to engage in the discussion of failed, unsuccessful procedures, lawsuits, litigations or complaint cases; comments of such nature, including external links, may be removed from the forum. Notify hairsite@aol.com any false, defamatory, misleading or inappropriate user generated contents for immediate removal from the forum. Also read Terms of Use & Privacy Statement |  HairSite advertisers: ASMED | Dr. Bhatti | Dr. Bisanga | Dr. Cole | Dr. Hakan Doganay | Dr.Epstein | Dr. Jones | Dr. Halder | Hasson & Wong | Dr. Klein | Dr. Madhu | Dr. Mwamba | Dr. Donald Ng| Dr. Poswal | Dr. Rahal | Dr. Razack | Dr. Reddy | Dr. Umar | Dr. Woods | DHI Global | HDC Clinic | |Lasercomb | Reviva Clinic | Ziering Medical|