Hair Loss - Treating hair loss with inhibitors of cholesterol synthesis

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HairSite Admin

21.05.2008, 05:46

Treating hair loss with inhibitors of cholesterol synthesis (Propecia, Avodart, Spiro, DHT & hormones ...)
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Androgens are synthesized from cholesterol.

So is it possible to decrease the androgen levels by preventing cholesterol synthesis?

There are various inhibitors of cholesterol synthesis like 'Statins'. Do they have any role to play in preventing hair loss?

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Bryan

21.05.2008, 12:53

@ HairSite Admin
Treating hair loss with inhibitors of cholesterol synthesis
Post reply

� Androgens are synthesized from cholesterol.
�
� So is it possible to decrease the androgen levels by preventing
� cholesterol synthesis?
�
� There are various inhibitors of cholesterol synthesis like 'Statins'.
� Do they have any role to play in preventing hair loss?

Probably not. I do recall seeing a study in a medical journal a few years ago which tested the effect of a substance which is known to inhibit the conversion of cholesterol into pregnenolone (if I recall correctly). That conversion is the first biochemical step in the process of turning cholesterol into steroid hormones, including androgens. Unfortunately, the experiment had no effect on balding. Again, I hope I'm remembering the details correctly. It was quite a while ago that I read that.

.

Bryan is located in [NA] and he is available to meet: NO

HairSite Admin

21.05.2008, 13:21

@ Bryan
Treating hair loss with inhibitors of cholesterol synthesis
Post reply

The study might have shown that it is not effective. But what is the reason??

Intake of Statins ---------------------> Low cholesterol
Low cholesterol --------------> Low androgens
Low androgens --------------------> Decreased hair loss

So intake of statins-------------------> no hair loss...

Is it not an attractive theory?

HairSite Admin is located in [NA] and he is available to meet: NO
---
I offer research assistance for HairSite.
email: hairsite@aol.com for free consultations
=====================================
reminder:
1. Help China Earthquake Victims
2. Free hair replacement system for men & women

Bryan

21.05.2008, 13:40

@ HairSite Admin
Treating hair loss with inhibitors of cholesterol synthesis
Post reply

� The study might have shown that it is not effective. But what is the
� reason??
�
� Intake of Statins ---------------------> Low cholesterol
� Low cholesterol --------------> Low androgens
� Low androgens --------------------> Decreased hair loss
�
� So intake of statins-------------------> no hair loss...
�
� Is it not an attractive theory?

I think the reason why it doesn't work is fairly obvious: there are so many feedback loops in the body, especially when it comes to the production and regulation of androgens, you can't just simply partially interefere with a far "upstream" factor like cholesterol synthesis and expect the effect to "trickle-down" into lower levels of androgens. Ahhhh, if only it were so simple! :-)

.

Bryan is located in [NA] and he is available to meet: NO

haroldo

26.05.2008, 04:57

@ HairSite Admin
Treating hair loss with inhibitors of cholesterol synthesis
Post reply

� The study might have shown that it is not effective. But what is the
� reason??
�
� Intake of Statins ---------------------> Low cholesterol
� Low cholesterol --------------> Low androgens
� Low androgens --------------------> Decreased hair loss
�
� So intake of statins-------------------> no hair loss...
�
� Is it not an attractive theory?

Statins are actually associated with hair loss. And inhibiting androgen production at such an early stage would be akin to castration if it did work. Oral Ketoconazole inhibits steroidogenesis if that is of interest. As does cyproterone acetate and I believe spironolacton (though perhaps only in the adrenal glands).
hh

haroldo is located in [NA] and he is available to meet: NO

HairSite Admin 21.05.2008, 05:46	Treating hair loss with inhibitors of cholesterol synthesis (Propecia, Avodart, Spiro, DHT & hormones ...) Post reply
	Androgens are synthesized from cholesterol. So is it possible to decrease the androgen levels by preventing cholesterol synthesis? There are various inhibitors of cholesterol synthesis like 'Statins'. Do they have any role to play in preventing hair loss? HairSite Admin is located in [NA] and he is available to meet: NO --- I offer research assistance for HairSite. email: hairsite@aol.com for free consultations ===================================== reminder: 1. Help China Earthquake Victims 2. Free hair replacement system for men & women
Bryan 21.05.2008, 12:53 @ HairSite Admin	Treating hair loss with inhibitors of cholesterol synthesis Post reply
	� Androgens are synthesized from cholesterol. � � So is it possible to decrease the androgen levels by preventing � cholesterol synthesis? � � There are various inhibitors of cholesterol synthesis like 'Statins'. � Do they have any role to play in preventing hair loss? Probably not. I do recall seeing a study in a medical journal a few years ago which tested the effect of a substance which is known to inhibit the conversion of cholesterol into pregnenolone (if I recall correctly). That conversion is the first biochemical step in the process of turning cholesterol into steroid hormones, including androgens. Unfortunately, the experiment had no effect on balding. Again, I hope I'm remembering the details correctly. It was quite a while ago that I read that. . Bryan is located in [NA] and he is available to meet: NO
HairSite Admin 21.05.2008, 13:21 @ Bryan	Treating hair loss with inhibitors of cholesterol synthesis Post reply
	The study might have shown that it is not effective. But what is the reason?? Intake of Statins ---------------------> Low cholesterol Low cholesterol --------------> Low androgens Low androgens --------------------> Decreased hair loss So intake of statins-------------------> no hair loss... Is it not an attractive theory? HairSite Admin is located in [NA] and he is available to meet: NO --- I offer research assistance for HairSite. email: hairsite@aol.com for free consultations ===================================== reminder: 1. Help China Earthquake Victims 2. Free hair replacement system for men & women
Bryan 21.05.2008, 13:40 @ HairSite Admin	Treating hair loss with inhibitors of cholesterol synthesis Post reply
	� The study might have shown that it is not effective. But what is the � reason?? � � Intake of Statins ---------------------> Low cholesterol � Low cholesterol --------------> Low androgens � Low androgens --------------------> Decreased hair loss � � So intake of statins-------------------> no hair loss... � � Is it not an attractive theory? I think the reason why it doesn't work is fairly obvious: there are so many feedback loops in the body, especially when it comes to the production and regulation of androgens, you can't just simply partially interefere with a far "upstream" factor like cholesterol synthesis and expect the effect to "trickle-down" into lower levels of androgens. Ahhhh, if only it were so simple! . Bryan is located in [NA] and he is available to meet: NO
haroldo 26.05.2008, 04:57 @ HairSite Admin	Treating hair loss with inhibitors of cholesterol synthesis Post reply
	� The study might have shown that it is not effective. But what is the � reason?? � � Intake of Statins ---------------------> Low cholesterol � Low cholesterol --------------> Low androgens � Low androgens --------------------> Decreased hair loss � � So intake of statins-------------------> no hair loss... � � Is it not an attractive theory? Statins are actually associated with hair loss. And inhibiting androgen production at such an early stage would be akin to castration if it did work. Oral Ketoconazole inhibits steroidogenesis if that is of interest. As does cyproterone acetate and I believe spironolacton (though perhaps only in the adrenal glands). hh haroldo is located in [NA] and he is available to meet: NO