goata007
16.06.2008, 00:40 |
Another example - Follica may actually work! (Hair Multiplication & Research) |
Someone asked Rassman this question last year about gefitinib:
"Have you ever heard of a drug called Gefitinib? P.A. Burt observed a few years ago that a patient treated with the drug who had been bald for many years experienced sudden robust hair growth. I know of one other anecdotal report in which a patient experienced terminal hair growth at the tip of his nose. Aside from this, I’m not able to find any other infromation on the drug. I wonder what its safety profile and mechanism of action would be, especially when administered concomitantly with finasteride. Cool, huh?"
Note the guy mentions "bald for many years". That's really exiciting, I was just talking about EGF inhibitor on another forum that how over expression of EGF could make it difficult for hair to grow and inhibiting it, followed by abrasion could actually help follicles.
There is a possibility that the bald guy probably shaved his head quite often, and when he got on gefitinib, he created a good environment for follicles to make terminal hair. Btw, People who don't know about gefitinib, this is one of the drugs used in Follica procedure
http://www.baldingblog.com/2007/07/27/gefitinib-grows-hair/
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
rev
your nightmares,
16.06.2008, 02:13
@ goata007
|
Another example - Follica may actually work! |
» Someone asked Rassman this question last year about
» gefitinib:
»
» "Have you ever heard of a drug called Gefitinib? P.A. Burt observed a
» few years ago that a patient treated with the drug who had been bald for
» many years experienced sudden robust hair growth. I know of one
» other anecdotal report in which a patient experienced terminal hair growth
» at the tip of his nose. Aside from this, I’m not able to find any other
» infromation on the drug. I wonder what its safety profile and mechanism of
» action would be, especially when administered concomitantly with
» finasteride. Cool, huh?"
»
» Note the guy mentions "bald for many years". That's really exiciting, I
» was just talking about EGF inhibitor on another forum that how over
» expression of EGF could make it difficult for hair to grow and inhibiting
» it, followed by abrasion could actually help follicles.
»
» There is a possibility that the bald guy probably shaved his head quite
» often, and when he got on gefitinib, he created a good environment for
» follicles to make terminal hair. Btw, People who don't know about
» gefitinib, this is one of the drugs used in Follica procedure
»
»
» http://www.baldingblog.com/2007/07/27/gefitinib-grows-hair/
That's definitely exciting.... it's like all those random bits of research, personal stories, and general information are starting to merge into a possible cure.
.
rev is located in YOUR NIGHTMARES and he is available to meet: NO |
debris
16.06.2008, 08:45
@ rev
|
Another example - Follica may actually work! |
interesting to hear. Someone should try it 
debris has 1 Personal Journal(s). Click here to view
debris is located in [NA] and he is available to meet: NO |
goata007
16.06.2008, 20:06
@ goata007
|
Another example - Follica may actually work! |
Does anyone know how to read this? when I open it, all I see is "Hair growth after gefitinib treatment." - I'd like to read the full study/report.
http://www.ncbi.nlm.nih.gov/pubmed/16149296
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
goata007
17.06.2008, 01:29
@ goata007
|
Another example - Follica may actually work! |
» Does anyone know how to read this? when I open it, all I see is "Hair
» growth after gefitinib treatment." - I'd like to read the full
» study/report.
»
» http://www.ncbi.nlm.nih.gov/pubmed/16149296
Can anyone please get this article/study??
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
biston
17.06.2008, 05:41
@ goata007
|
Another example - Follica may actually work! |
someone can explains to me why this news argues in favour of follica?
biston is located in [NA] and he is available to meet: NO |
risc
17.06.2008, 05:49
@ goata007
|
Another example - Follica may actually work! |
» » Does anyone know how to read this? when I open it, all I see is "Hair
» » growth after gefitinib treatment." - I'd like to read the full
» » study/report.
» »
» »
» http://www.ncbi.nlm.nih.gov/pubmed/16149296
»
» Can anyone please get this article/study??
I have uploaded the article published in Clinical Oncology : http://r a p i d s h a r e.com/files/123035732/Hair_growth_after_gefitinib_treatment.pdf.html
( pls remove spaces "r a p i d s h a r e" ) 
risc is located in [NA] and he is available to meet: NO |
biston
17.06.2008, 07:03
@ biston
|
someone can explains to me why this news argues in favour of follica? |
» someone can explains to me why this news argues in favour of follica?
/nt
biston is located in [NA] and he is available to meet: NO |
goata007
17.06.2008, 09:48
(edited by goata007, 17.06.2008, 10:10)
@ risc
|
Another example - Follica may actually work! |
Thanks risc!
Favorite part:
He was started on gefitinib 250 mg daily in July 2004, which he tolerated well. In August 2004, he was pleasantly surprised by new hair growth in
a previously long-standing bald patch on the vertex of his scalp (Fig. 1).
The hair was of a different colour and texture to his normal hair. In May
2005, he is still on gefitinib and enjoying his new appearance.
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
biston
17.06.2008, 10:27
@ goata007
|
Another example - Follica may actually work! |
If I understood correctly, follica use gefitinib? however we need a pre-treatment photo
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TAGOHL
17.06.2008, 11:29
@ goata007
|
Another example - Follica may actually work! |
» Thanks risc!
Can I ask you a big favor? That web site is blocked for me, so can you post the article here? Thanks.
TAGOHL is located in [NA] and he is available to meet: NO |
debris
17.06.2008, 16:54
@ goata007
|
This is quite significant guys. Here's the image. |
![[image]](img/uploaded/129_image1.jpg) Heres the image. the hair with the different texture is supposedly the new hair. If that is true then well I can't say anything else then that it's awesome not perfect but still awesome.
debris has 1 Personal Journal(s). Click here to view
debris is located in [NA] and he is available to meet: NO
|
debris
17.06.2008, 16:55
@ debris
|
Text of the article is here |
Heres the text of the article:
Correspondence
doi:10.1016/j.clon.2005.05.001
Hypothyroidism in Thyroid Carcinoma Follow-up: Orlistat
May Inhibit the Absorption of Thyroxine
Sir d Orlistat is used in the management of obesity to reduce the
absorption of fat. Thyroxine is used in the management of welldifferentiated
thyroid cancer to suppress thyroid-stimulating hormone
(TSH) production. We report a case of symptomatic hypothyroidism
occurring after the commencement of orlistat in a patient with papillary
carcinoma of the thyroid.
After total thyroidectomy and radio-iodine ablation, suppression of
TSH by the anterior pituitary is part of the standard management
of differentiated thyroid cancer [1]. Doses of thyroxine in the order of
175–200 mg are commonly required to produce adequate suppression
[2]. Orlistat is a recently licenced drug used in obesity management.
Orlistat promotes weight loss by reducing the absorption of energy
dense fat. It is a potent inhibitor of pancreatic and gastric lipases,
allowing about 30% of dietary fat to pass through the gastrointestinal
tract unabsorbed [3].
A 46-year-old woman was diagnosed in August 2002 with papillary
carcinoma of the thyroid. After completing thyroidectomy in September
2002, and radio-active iodine (I131 3000 MBq) ablation therapy in
December 2002, she was commenced on 250 mg of thyroxine daily.
Thyroid function tests carried out in May 2004 revealed serum thyroxine
(T4) level of 25.2 pmol/L and TSH 0.03 mU/L, indicating nearly adequate
suppression of TSH.
In June 2004, she was commenced on orlistat by her general
practitioner. Within 2 weeks, she experienced hypothyroid symptoms in
the form of tiredness, lethargy and cold intolerance. Biochemically, she
was found to be profoundly hypothyroid with T4 7 pmol/L and TSH
73.6 mU/L. During this period, the patient’s husband witnessed good
compliance with medication.
The woman was advised to discontinue orlistat, and her thyroxine was
increased to 300 mcu once daily. Within 2 weeks, her symptoms improved.
Repeat blood tests carried out 4 weeks later showed TSH 0.02 mU/L and
T4 31.7 pmol/L.
Causes of inadequate TSH suppression include inadequate thyroxine
dose due to poor patient compliance or reduction to a replacement dose by
the general practitioner. Clear communication of the rationale behind TSH
suppression is therefore essential. In this case, the patient had been
compliant with thyroxine for 18 months as indicated by her previous
biochemistry, and both the patient and her husband were adamant that she
had continued to comply.
Orlistat has been associated with gastrointestinal adverse events,
including diarrhoea, constipation, abdominal pain and flatulence. In
addition, orlistat is known to cause malabsorption of fat soluble vitamins,
hypocalcaemia, and, rarely, other electrolyte disturbances. Thyroid
dysfunction is very rare [4].
Thyroxine has a bioavailability of 40–80% after oral administration. The
extent of thyroxine absorption is increased in the fasting state, and is
influenced by the content of the gastrointestinal tract. Some substances
bind the thyroxine, making it unavailable for diffusion across the gut wall
[5]. It may be that orlistat also binds to the thyroxine and prevents its
absorption from the small intestine.
We believe that this is the first reported case of hypothyroidsm in
a patient taking TSH suppressive dose of both thyroxine and orlistat. It is
clearly important that clinical oncologists, thyroid surgeons, endocrinologists
and general practitioners involved in the follow-up of thyroid cancer
patients are aware of this potential interference of this drug with thyroxine
absorption.
K. MADHAVA
A. HARTLEY
Queen Elizabeth Hospital, Birmingham, UK
References
1 Halnan KE. Thyroid. In: Price P, Sikora K, eds. Treatment of cancer.
London: Chapman and Hall, 1995. p. 367–390.
2 Guidelines for the management of thyroid cancer in adults. British
Thyroid Association, Royal College of Physicians; March 2002.
3 Hollander PA, Elbein SC, Hirsch IB, et al. Role of orlistat in the
treatment of obese patients with type 2 diabetes. A 1-year randomized
controlled study. Diabetes Care 1998;21:1288–1294.
4 Mc Duffie JR, Calis KA, Booth SL, Uwaifo GI, Yanovski JA. Effects of
orlistat on fat soluble vitamins in obese adolescents. Pharmacotherapy
2002;22:814–822.
5 Roberts G. Taking care of thyroxine. Aust Prescr 2004;27:75–76.
doi:10.1016/j.clon.2005.05.002
Hair Growth After Gefitinib Treatment
Sir d We report an interesting case of new hair growth after gefitinib
treatment. A 57-year-old man with androgenic alopecia first presented with
back pain in January 2004. A bone scan showed increased uptake in
the sacrum, and the lumbar spine. A biopsy of the spine confirmed
adenocarcinoma consistent with non-small-cell lung cancer. A computed
Fig. 1 – New hair growth on previous bald vertex.
Clinical Oncology (2005) 17: 492–493
0936-6555/05/000000C02 $35.00/0 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
debris has 1 Personal Journal(s). Click here to view
debris is located in [NA] and he is available to meet: NO |
Amilcar
17.06.2008, 17:21
@ debris
|
Text of the article is here |
Thanks debris ..could not get my hand on the study...we need to check every section of it ...
Thats unfortunate that benji is not here..
Also JB ..if u r here ..just make a living sign man !
Amilcar is located in [NA] and he is available to meet: NO |
goata007
17.06.2008, 17:25
@ Amilcar
|
Text of the article is here |
» Thanks debris ..could not get my hand on the study...we need to check every
» section of it ...
Actually *this* is the right one and it's just an observation (nothing scientific in here):
"Sir d We report an interesting case of new hair growth after gefitinib
treatment. A 57-year-old man with androgenic alopecia first presented with
back pain in January 2004. A bone scan showed increased uptake in
the sacrum, and the lumbar spine. A biopsy of the spine confirmed
adenocarcinoma consistent with non-small-cell lung cancer. A computed tomography/positron emission tomography scan confirmed lung cancer in
February 2004. He received fractionated palliative radiotherapy to the
sacrum in February 2004, with good symptomatic response. Subsequently,
he received three cycles of carboplatin and gemcitabine chemotherapy
between March and June 2004. Unfortunately, chemotherapy had to be
discontinued because of toxicity and also new-onset deep venous
thromboembolism, for which he was anticoagulated. He was started on
gefitinib 250 mg daily in July 2004, which he tolerated well.
In August 2004, he was pleasantly surprised by new hair growth in
a previously long-standing bald patch on the vertex of his scalp (Fig. 1).
The hair was of a different colour and texture to his normal hair. In May
2005, he is still on gefitinib and enjoying his new appearance.
Gefitinib, also known as ZD1839, is a new oral epidermal growth factor
receptor tyrosine kinase inhibitor that has been used for lung cancer. It
blocks signal transduction pathways implicated in the survival and
proliferation of tumour cells and other host dependent pathways in
tumourogenesis [1]. Epidermal growth factor receptor is important for
normal skin and hair development and growth [2]. Gefitinib is well known to
be associated with skin rashes, such as acneiform follicular papules and
pustules [3].Acase report has been published on excessive increase in length
of eyelashes and eyebrows in a patient who also had acneiform rashes after
gefitinib [4]. In three monotherapy clinical studies of IRESSA 250 mg/day,
only one patient out of a total of 1331 had mild common toxicity criteria
grade 1 hair disorder [3]. However, no previous report of new hair growth in
a previous bald patch has been described. Therefore, this is an interesting
case illustrating an unusual positive side-effect of a novel anticancer drug."
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
Sceptic
17.06.2008, 18:56
@ goata007
|
Text of the article is here |
" ... palliative radiotherapy ... "
Unfortunately, it's possible that the poor man is not here with us anymore 
Fu*king cancer !
Sceptic is located in [NA] and he is available to meet: NO |
cal
17.06.2008, 19:27
@ Sceptic
|
Text of the article is here |
I'm not sure what to make of the hair difference.
But it is relevant that this patient grew this hair cold turkey - no depilation 3 days before, no wounding whatsoever(!), no 5-day wait between injury and the beginning of EGF-R inhibition, no stoppage of the EGF-R inhibition after 7-10 days.
I think if the hair can be grown like this with so many of the factors totally missing . . . good sign. Very good sign, at least for the idea of getting any growth at all.
Another thing that looks good: The hair isn't white.
cal is located in [NA] and he is available to meet: NO |
goata007
17.06.2008, 20:02
@ cal
|
Text of the article is here |
» Another thing that looks good: The hair isn't white.
+1...Plus cosmetically - it looks great, no one can tell if that's new hair if it weren't for the color difference.
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
TAGOHL
17.06.2008, 20:24
@ risc
|
Thanks, risc |
For a drug, the density of regrowth is impressive.
I've been staring at a bottle of gefitinib for about the past 10 days, not yet having cracked the seal. It seems too good to be true. I'm a believer and a non-believer at the same time. We shall see.
TAGOHL is located in [NA] and he is available to meet: NO |
cal
17.06.2008, 21:10
@ TAGOHL
|
Thanks, risc |
I can't resist asking where you got it, how much money for how much drug, etc.
Another thing about trying this at home is the prospect of counterfeit drugs. A couple of guys trying Folica's method with some fake drugs could incorrectly shatter a lot of hope for us for a while.
Just something to think about if we start getting word of amateur attempts at Folica's method that fail.
cal is located in [NA] and he is available to meet: NO |
dave21
17.06.2008, 23:22
@ TAGOHL
|
Thanks, risc |
» For a drug, the density of regrowth is impressive.
»
» I've been staring at a bottle of gefitinib for about the past 10 days, not
» yet having cracked the seal. It seems too good to be true. I'm a believer
» and a non-believer at the same time. We shall see.
The seal should be cracked. Lol. Where did you find some at if you don't mind me asking?
dave21 is located in [NA] and he is available to meet: NO |
goata007
17.06.2008, 23:38
@ TAGOHL
|
Thanks, risc |
» I've been staring at a bottle of gefitinib for about the past 10 days, not
» yet having cracked the seal. It seems too good to be true. I'm a believer
» and a non-believer at the same time. We shall see.
I highly doubt it was just gefitinib that caused hair growth, there must have been some other factor - possibly part of that guy's routine i.e. eating something, shaving head or what not - that contributed significantly to hair growth. If it was just gefitinib then we would have heard about a lot of similar cases.
I really liked the way author wrote "...he is still on gefitinib and enjoying his new appearance." - hell yeah he is!
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
cal
18.06.2008, 00:47
@ goata007
|
Thanks, risc |
Maybe he was shaving his bald areas. That would be my strongest guess. And maybe some other medication amped-up the effect (immunosuppression meds of some other sort?)
Well, regardless of what else he was doing, I think it's still a pretty safe bet he didn't follow all of Folica's complicated instructions just right.
And something grew anyway. Something that looks a lot better than the BHTs that some guys have paid so much for.
More observations:
-- The new hair's differences between the rest of his old hair look like at least partially just the result of being younger in nature. The new hairs look thicker. They also look darker in color, but I'm not sure that the darker issue is truly a shade difference. In this case I think it may just be the absence of any greys in the new growth.
-- This guy may not have even been on any DHT inhibitors at the time he grew this. Potentially yet another good sign.
-- It also occurs to me that the continuation of the Gentifib AFTER the formation of any given hair follicle is probably a bad thing rather than a good one. (Leflunomide has actually caused complaints of hurting hair growth after several weeks/months.) His results might look better still if the Gentifib wasn't being continued after a given hair was formed.
cal is located in [NA] and he is available to meet: NO |
debris
18.06.2008, 01:31
@ goata007
|
Text of the article is here |
Cheers goata, I did not notice that it pasted only the first page and not the rest of it where it actuall talks about the hair
Whats interesting that it says that only 1 guy out of 1331 had this hairy sideeffect.
He must have done something differently.
debris has 1 Personal Journal(s). Click here to view
debris is located in [NA] and he is available to meet: NO |
benji
18.06.2008, 03:52
@ TAGOHL
|
TAGOHL, where did you get the getifitinib? |
» For a drug, the density of regrowth is impressive.
»
» I've been staring at a bottle of gefitinib for about the past 10 days, not
» yet having cracked the seal. It seems too good to be true. I'm a believer
» and a non-believer at the same time. We shall see.
I haven't been able to find it anywhere without a doc's prescript.....
I have found Arava online supposedly without a prescript (if the site is legit).
To me, the biggest issue for "mainstreaming" follica someday (if it works in humans) for them is the fact that if it works like the patent suggests.....it really could be pretty easily replicated at home. All the necessary drugs can be taken orally (dutas, getifitinib, loniten, anti-histamine, lithium salts), so basically its depilate, wound on day three, start taking internals on day six, quit on day 16, dont use an anti-infective on the wound during healing.........that is about it.
TAGOHL, Ive also though that in the months leading up to "doing the procedure", one might use substances on the scalp that have been shown to decrease androgen-receptor expression in human cells (curcumoids, black tea flavoniods, fluridil, etc.) in hopes that the treated area might have less androgen receptor expression when it "remakes itself". Fluridil is actually in parts of the patent as is flutamide----I HOPE that if it works, that SOMEDAY "they" (its always "they" when referencing future scientific advances isn't it?) will be able to block certain genes during the process in which this hair is created and perhaps it wont have any tendencey to be MPB hair at all.......
I dont want to be excited about Follica out of the "hope/desperation" we saw people on this board be excited about Gho/Bazan/Washenik/Neosil/Kemp etc., but in reality........I cannot see any other way to "make" new hair from scratch other than HM, or either Follica or ACELL. Nothing else, other than perhaps creating tissue matrices where HM cells can be grown into fully differentiated hairs outside the body, that I can envision would create real "new" hair. If this does not work, and ACELL doesn't work.........I dont think anything ever will and men will simply be looking for ways to re-enlarge miniaturized hair (which I think wont work in vivo because long-miniaturized hair loses CD200 immuno-markers over time, and thus loses its autoimmune priveleges in any mammal with an immune system, and we aren't SCID mice).......henceforth I "hope" either Follica or ACELL works.
benji is located in [NA] and he is available to meet: NO |
benji
18.06.2008, 03:59
@ cal
|
Text of the article is here |
» I'm not sure what to make of the hair difference.
»
» But it is relevant that this patient grew this hair cold turkey - no
» depilation 3 days before, no wounding whatsoever(!), no 5-day wait between
» injury and the beginning of EGF-R inhibition, no stoppage of the EGF-R
» inhibition after 7-10 days.
»
» I think if the hair can be grown like this with so many of the factors
» totally missing . . . good sign. Very good sign, at least for the idea of
» getting any growth at all.
»
»
»
» Another thing that looks good: The hair isn't white.
as debris has pointed out, this is the only guy that grew hair.......i wonder if he might have shampooed his head a little harshly, or wore a hat that was a bit tight, or used a harsh shampoo up there, or was scratching his head (maybe he has dandruff) or anything that could have irritated the dermis and set this process off.........................the hair created looks a bit like very robust body hair if you look closely........
the good news is this: just imagine if he was on an anti-androgen, minoxidil, an anti-histamine, and used lithium while the hair was being "made", it might be even thicker and the hairs even larger........
benji is located in [NA] and he is available to meet: NO |
cal
18.06.2008, 05:06
@ benji
|
Text of the article is here |
Benji, to point this out again:
Leflunomide has the EGF-R properties that we're hoping will grow hairs. But the much more common complaint from Leflunomide patients has been from hair LOSS than gain (at least after several weeks or months on the drug). That suggests to me that continuing the EGF-R blocking after the critical period might do more harm than good for new hairs. Either that or else Folica missed something BIG about the whole process.
I think just that issue alone could help explain some of the imperfect hair growth we see on the Gentifib patient's head in the pics. (But look at his density- NOT BAD to my eyes. If that new hair was thicker-shafted and longer it might look quite good. This isn't the kind of weak scattering of grafts that we've trained ourselves to expect from previous HM efforts.)
As for the drugs, I'm wondering two things:
1. Do you know how Leflunomide might compare to Gentifib in the critical EGF-R issue? I know Gentifib looks like the better shot for skin absorption, but what about orally? If I wanna mess with this now then could I just use oral Arava and skip the Gentifib?
2. Have we ever decided what Loniten & Minox & the antihistamine are bringing to the table? Anything major?
cal is located in [NA] and he is available to meet: NO |
cal
18.06.2008, 06:40
@ cal
|
Text of the article is here |
(bump)
cal is located in [NA] and he is available to meet: NO |
risc
18.06.2008, 07:15
(edited by risc, 18.06.2008, 07:53)
@ goata007
|
an interesting publication on gefitinib |
I find this article interesting " Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib "
Published (August 2006) in the Journal of the American Academy of Dermatology.
link to this article > http://r a p i d s h a r e.com/files/123296392/the_epidermal_growth_factor_receptor_inhibitor_gefitinib.pdf.html
or
http://www.m e g a f i l e u p l o a d.com/en/file/70473/the-epidermal-growth-factor-receptor-inhibitor-gefitinib-pdf.html
( pls remove spaces )
risc is located in [NA] and he is available to meet: NO |
Amilcar
18.06.2008, 07:21
@ risc
|
To risc |
Dear risc,
Would you please upload the studies in another filesharing site as Rapidshare is blocked for many of board members (including myself).
I still didt not see the entire gefitnib study.
Best Regards.
Amilcar is located in [NA] and he is available to meet: NO |
risc
18.06.2008, 08:07
@ Amilcar
|
updated with new link |
I find this article interesting " Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib "
Published (August 2006) in the Journal of the American Academy of Dermatology.
link to this article > http://r a p i d s h a r e.com/files/123296392/the_epidermal_growth_factor_receptor_inhibitor_gefitinib.pdf.html
or
http://www.m e g a f i l e u p l o a d.com/en/file/70473/the-epidermal-growth-factor-receptor-inhibitor-gefitinib-pdf.html
( pls remove spaces )
risc is located in [NA] and he is available to meet: NO |
Amilcar
18.06.2008, 08:18
@ risc
|
updated with new link |
risc, Thank you so much.
Amilcar is located in [NA] and he is available to meet: NO |
goata007
18.06.2008, 09:25
@ debris
|
This is quite significant guys. Here's the image. |
I emailed Dr. Burt (the one who wrote the article) and following is his response.
"The patient maintained his hair up until death. The quality of the hair was finer and more like baby hair. He was able to go to his daughter's wedding with his new hair. Hair growth with EGFR receptor inhibitors is common but is often in unwanted areas. I have 2 patients whose eyelash growth on erlotinib is so intense they have to keep trimming them. Facial hair in women is a problem. As far as I am aware Astra Zeneca have not taken this side effect further. Gefitinib failed to get a license in the UK for treating non small cell lung cancer having had a set of adverse trial results which dramatically affected AZ's share price. It has been superceeded by erlotinib manufactured by Roche."
goata007 is located in [NA] and he is available to meet: NO ---
"If we knew what it was that we were doing, it wouldn't be called research, would it?" - Albert Einstein |
TAGOHL
18.06.2008, 10:17
@ benji
|
Benji... |
Real quick, I am in a hurry...
» I haven't been able to find it anywhere without a doc's prescript.....
3gchemist.com. Cost is $375 USD (+ $20 shipping) for 30 tabs @ 250mg. It's a generic version made by an Indian drug firm. I had never used this pharmacy before, but delivery was fast (they also give you a tracking number), and no script was required (even though the verbage on the website indicates you need one...there's a checkbox or radio button when you select the item asking if the drug you are buying needs a script...you just select no).
I can give you some other places that I've used before which sell the brand name version, but the price exceeds $2K for 30 tabs.
TAGOHL is located in [NA] and he is available to meet: NO |
TAGOHL
18.06.2008, 11:27
@ cal
|
Text of the article is here |
» Benji, to point this out again:
»
» Leflunomide has the EGF-R properties
This is an ancillary property of the drug.
» That suggests to me that continuing the EGF-R blocking after the critical
» period might do more harm than good for new hairs.
Hair loss isn't a complaint with long-term gefitinib use, but it is with leflunomide, which means the hair loss isn't likely the result of blockade of the EGFR (otherwise, both drugs would cause hair loss).
» 1. Do you know how Leflunomide might compare to Gentifib in the critical
» EGF-R issue?
It's not likely to be as good, IMO. Also, leflunomide is a dirty drug in the sense that it does a lot more than interfere with the EGF pathway. So, while you may get some EGF antagonism, you are getting other stuff that you may not want. A couple of other downsides: leflunomide is a pro-drug (which means in order for it to work, it needs to be converted to its active form...which may or may not happen if it's used topically), and it has a very long half-life after oral use (meaning you'll still be getting its effects for a long while after stopping the drug).
» 2. Have we ever decided what Loniten & Minox & the antihistamine are
» bringing to the table? Anything major?
According to the patent, minoxidil enhances follicular neogenesis after wounding.
TAGOHL is located in [NA] and he is available to meet: NO |
Baccy
18.06.2008, 12:22
@ TAGOHL
|
Text of the article is here |
Does the patent require topical application of gefitinib or oral ingestion?
Baccy has 1 Personal Journal(s). Click here to view
Baccy is located in [NA] and he is available to meet: NO |
bug2
18.06.2008, 12:34
@ TAGOHL
|
Benji... |
» Real quick, I am in a hurry...
»
» » I haven't been able to find it anywhere without a doc's prescript.....
»
» 3gchemist.com. Cost is $375 USD (+ $20 shipping) for 30 tabs @ 250mg. It's
» a generic version made by an Indian drug firm. I had never used this
» pharmacy before, but delivery was fast (they also give you a tracking
» number), and no script was required (even though the verbage on the website
» indicates you need one...there's a checkbox or radio button when you select
» the item asking if the drug you are buying needs a script...you just select
» no).
»
» I can give you some other places that I've used before which sell the
» brand name version, but the price exceeds $2K for 30 tabs.
Damnit nix
bug2 is located in [NA] and he is available to meet: NO |
debris
18.06.2008, 12:54
@ benji
|
Text of the article is here |
Maybe he just had a hair transplant and was too ashamed to admit it to the woman doctor
debris has 1 Personal Journal(s). Click here to view
debris is located in [NA] and he is available to meet: NO |
Mr. Frodo
18.06.2008, 12:55
@ goata007
|
This is quite significant guys. Here's the image. |
» I emailed Dr. Burt (the one who wrote the article) and following is his
» response.
»
» "The patient maintained his hair up until death. The quality of the
» hair was finer and more like baby hair. He was able to go to his
» daughter's wedding with his new hair. Hair growth with EGFR receptor
» inhibitors is common but is often in unwanted areas. I have 2 patients
» whose eyelash growth on erlotinib is so intense they have to keep trimming
» them. Facial hair in women is a problem. As far as I am aware Astra Zeneca
» have not taken this side effect further. Gefitinib failed to get a license
» in the UK for treating non small cell lung cancer having had a set of
» adverse trial results which dramatically affected AZ's share price. It has
» been superceeded by erlotinib manufactured by Roche."
i think this forum has totally lost it, you guys are thinking of using cancer drugs to treat hair loss ?
Mr. Frodo is located in [NA] and he is available to meet: NO |
debris
18.06.2008, 12:57
@ goata007
|
This is quite significant guys. Here's the image. |
That just shows how hair is not important really.
» I emailed Dr. Burt (the one who wrote the article) and following is his
» response.
»
» "The patient maintained his hair up until death. The quality of the
» hair was finer and more like baby hair. He was able to go to his
» daughter's wedding with his new hair. Hair growth with EGFR receptor
» inhibitors is common but is often in unwanted areas. I have 2 patients
» whose eyelash growth on erlotinib is so intense they have to keep trimming
» them. Facial hair in women is a problem. As far as I am aware Astra Zeneca
» have not taken this side effect further. Gefitinib failed to get a license
» in the UK for treating non small cell lung cancer having had a set of
» adverse trial results which dramatically affected AZ's share price. It has
» been superceeded by erlotinib manufactured by Roche."
debris has 1 Personal Journal(s). Click here to view
debris is located in [NA] and he is available to meet: NO |
TAGOHL
18.06.2008, 13:33
@ Baccy
|
Text of the article is here |
» Does the patent require topical application of gefitinib or oral ingestion?
The patent focuses on topical application, but it does mention oral administration as an alternative.
BTW, gefitinib is only one of several drugs mentioned in the patent. What you want to do is inhibit epidermal growth factor (EGF) -- several drugs are on the market that do this...gefitinib happens to be one of them.
TAGOHL is located in [NA] and he is available to meet: NO |
TAGOHL
18.06.2008, 13:42
@ bug2
|
Benji... |
» Damnit nix
Nix was kind enough to post that source, but I had already found that website even before I asked him which site he was referring to. Of course, the day after I placed the order, another site agreed to sell it to me cheaper - $350 for 30 tabs...oh well.
TAGOHL is located in [NA] and he is available to meet: NO |
cal
18.06.2008, 13:49
@ TAGOHL
|
Text of the article is here |
Mr. Frodo -
Those Gentifib issues are a bunch of systemic problems with long-term oral use. We're talking short-term topical use for hair.
TAGOHL -
Yeah, I know Leflunomide isn't without issues if taken orally. I've read about the sides, the need to use activated charcoal or something to kick the stuff out of the body as soon as you want it gone, etc.
I just prefer temporary Leflunomide side effects over the long-term side effects of being bald, ya know what I mean? I'd give myself two weeks of the shiits or stomach aches or anything else I have to do if it'll regrow real hair right now and not 5 years from now.
But if this Gentifib source is legit then $375 for the cream of the crop sounds like a better idea (Even ghetto overseas Leflunomide still isn't VERY cheap).
Or even do some of both oral Leflu & topical Genti? We have no real dosage & topical mixture information on this stuff yet. And the patents don't give any specifics beyond that "some conbination of" wording. Can we go wrong with too much EGF-R inhibition?
cal is located in [NA] and he is available to meet: NO |
TAGOHL
18.06.2008, 13:53
@ risc
|
To Risc |
Can you get either of the following?
J Am Acad Dermatol. 2008 Apr;58(4):642-3.
Epidermal growth factor receptor inhibitors and hair.
Heymann WR.
PMID: 18342710 [PubMed - indexed for MEDLINE]
An unusual terminal hair growth on the nose tip associated with gefitinib therapy.
Br J Dermatol. 2007 May;156(5):1087-8.
PMID: 17388923 [PubMed - indexed for MEDLINE]
TAGOHL is located in [NA] and he is available to meet: NO |
TAGOHL
18.06.2008, 14:17
@ cal
|
Text of the article is here |
I also prefer oral over topical, and 10 days isn't that long.
I'm not sure about combining leflunomide with gefitinib. I think gefitinib alone (either orally or topically) would probably be plenty. Leflunomide by itself may also be an option. The patent indicates the topical can have multiple drugs (EGF inhibitor, minox, finasteride, etc.), but IIRC, only one of the EGF inhibitors is used.
TAGOHL is located in [NA] and he is available to meet: NO |
risc
18.06.2008, 14:40
@ TAGOHL
|
...find just one article. |
» Can you get either of the following?
»
» J Am Acad Dermatol. 2008 Apr;58(4):642-3.
»
» Epidermal growth factor receptor inhibitors and hair.
»
» Heymann WR.
»
» PMID: 18342710 [PubMed - indexed for MEDLINE]
»
link > http://www.m e g a f i l e u p l o a d.com/en/file/70534/EpGrowthFacReceptorInhibitors-and-hair-pdf.html
risc is located in [NA] and he is available to meet: NO |
Baccy
18.06.2008, 15:45
@ risc
|
...find just one article. |
» » Can you get either of the following?
» »
» » J Am Acad Dermatol. 2008 Apr;58(4):642-3.
» »
» » Epidermal growth factor receptor inhibitors and hair.
» »
» » Heymann WR.
» »
» » PMID: 18342710 [PubMed - indexed for MEDLINE]
» »
»
»
» link > http://www.m e g a f i l e u p l o a
» d.com/en/file/70534/EpGrowthFacReceptorInhibitors-and-hair-pdf.html
It looks like the effects of Gefitinib conflict with Follica's patent. Unless the action of the drug radically alters with the introduction of epidermal wounding.
Baccy has 1 Personal Journal(s). Click here to view
Baccy is located in [NA] and he is available to meet: NO |
benji
18.06.2008, 16:19
@ TAGOHL
|
Benji... |
» » Damnit nix
»
» Nix was kind enough to post that source, but I had already found that
» website even before I asked him which site he was referring to. Of course,
» the day after I placed the order, another site agreed to sell it to me
» cheaper - $350 for 30 tabs...oh well.
thank you very much TAGHOL, I will be looking into this. Ive stated to others online that if they are thinking about trying a spot of the procedure, they might as well and try to cop the procedure as closely as possible....and for that they'd need what follica is using as much as possible.
benji is located in [NA] and he is available to meet: NO |
TAGOHL
18.06.2008, 16:51
@ risc
|
Thanks! N/T |
N/T
TAGOHL is located in [NA] and he is available to meet: NO |
cal
19.06.2008, 05:14
@ TAGOHL
|
Thanks! N/T |
I can't imagine needing a whole batch of 30 Gentifib pills just for experimenting with a home-brewed topical on some test patches.
You guys with the $375 Gentifib bottles - Anybody wanna sell me a few of your pills thru the mail or something?
cal is located in [NA] and he is available to meet: NO |
risc
19.06.2008, 05:52
@ risc
|
the second publication |
» » Can you get either of the following?
» »
» An unusual terminal hair growth on the nose tip associated with gefitinib
» therapy.
»
» Br J Dermatol. 2007 May;156(5):1087-8.
»
» PMID: 17388923 [PubMed - indexed for MEDLINE]
» »
link > http://www.m e g a f i l e u p l o a d.com/en/file/70629/AnUnusTermHairGrowOnTheNosTipAssoWithGefitinibTher-pdf.html
risc is located in [NA] and he is available to meet: NO |
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