Hair Loss - HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn

Hair Transplant Reviews & Patient Records

Dogstar

07.10.2008, 15:22

HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn (Hair Multiplication & Research)
Post reply

http://www.marketwatch.com/news/story/hairdx-announces-clinical-trial-genetically/story.aspx?guid=%7B8BA640AC-998C-4B79-B4B8-39A9A9B18349%7D&dist=hppr

I don't know if this will be beneficial to MPB but it maybe another step in that direction.

Does anyone know the company that's involved and whether they are trustworthy or not.

Dogstar is located in [NA] and he is available to meet: NO

mjones

07.10.2008, 16:06

@ Dogstar
HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn
Post reply

� http://www.marketwatch.com/news/story/hairdx-announces-clinical-trial-genetically/story.aspx?guid=%7B8BA640AC-998C-4B79-B4B8-39A9A9B18349%7D&dist=hppr
�
� I don't know if this will be beneficial to MPB but it maybe another step
� in that direction.
�
� Does anyone know the company that's involved and whether they are
� trustworthy or not.

That sounds like awesome news!! whatever it is its involving genes...so it must be related to MPB....

mjones is located in [NA] and he is available to meet: NO

dave21

07.10.2008, 16:52

@ mjones
HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn
Post reply

And why is this only for women at the moment? :-|

dave21 is located in [NA] and he is available to meet: NO

european

07.10.2008, 19:33

@ dave21
HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn
Post reply

� And why is this only for women at the moment? :-|

I think thats not really anything we should count on. HairDX is a company that sells a test to doctors which acts like a genetics screening for females and males to determine how much they are likely to lose their hair.
So their business is most likely just to analyse genes, not to change them in any way (because thats really much much more difficult and would be revolutionary).

So why it's only for women? I think because men already have finasteride. It sounds like all they intend to do is make a genetic screening and then give the woman a fitting therapy (like with topical spiro or whatever women use).

""Dermatologists often prescribe women drugs for the treatment of hair loss; however, only a fraction of women respond to the therapy. If the HairDX clinical trial proves successful, dermatologists will be able to individually tailor treatment for hair loss based on a woman's genetic makeup," said Professor Doron Lancet, Head of the Crown Human Genome Center at the Department of Molecular Genetics, Weizmann Institute of Science."

Gene therapy is really far away for us balding guys, thats a fact to face, and HairDX won't really help us with that, except telling us how likely we are to go bald (which unfortunately doesnt change the outcome....)

european is located in [NA] and he is available to meet: NO

Dogstar

07.10.2008, 21:39

@ european
HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn
Post reply

� � And why is this only for women at the moment? :-|
�
� I think thats not really anything we should count on. HairDX is a company
� that sells a test to doctors which acts like a genetics screening for
� females and males to determine how much they are likely to lose their hair.
�
� So their business is most likely just to analyse genes, not to change them
� in any way (because thats really much much more difficult and would be
� revolutionary).
�
� So why it's only for women? I think because men already have finasteride.
� It sounds like all they intend to do is make a genetic screening and then
� give the woman a fitting therapy (like with topical spiro or whatever women
� use).
�
� ""Dermatologists often prescribe women drugs for the treatment of hair
� loss; however, only a fraction of women respond to the therapy. If the
� HairDX clinical trial proves successful, dermatologists will be able to
� individually tailor treatment for hair loss based on a woman's genetic
� makeup," said Professor Doron Lancet, Head of the Crown Human Genome Center
� at the Department of Molecular Genetics, Weizmann Institute of Science."
�
� Gene therapy is really far away for us balding guys, thats a fact to face,
� and HairDX won't really help us with that, except telling us how likely we
� are to go bald (which unfortunately doesnt change the outcome....)

Well there you go folks it's taken less than 24 hours for a person who isn't involved in anyway whatsoever to dismiss it, This is before we have any real facts about what it is they will be doing.

Dogstar is located in [NA] and he is available to meet: NO

european

09.10.2008, 22:36

@ Dogstar
HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn
Post reply

�
� Well there you go folks it's taken less than 24 hours for a person who
� isn't involved in anyway whatsoever to dismiss it, This is before we have
� any real facts about what it is they will be doing.

I didn't dismiss anything, i just shared my thoughts (read: "i THINK" in my reply). In such cases you just read over the article and make up your mind. In this case all i did was doing the maths. Face a few simple facts:

- If they had a genetic "cure" in their hands, they would give a sh*t about women's hairloss, as they would as any company like to make some money.

- Genetherapy just is something completely different then analysing genes. It takes the whole thing to a different level, and it is still in the beginning of development (how many working genetherapies which are really used do you know?)

- just really READ the article and tell me where it says that they gonna CHANGE ANYTHING with the genes. All they do is supporting a Therapy based on the genes, that might me a really cool thing, but its no a breakthrough.

- Why are women of special interest for this company? Maybe because most people they screen are women, as naturally women are more concerned about their looks than men (except gay men maybe) so they are more likely to pay a company money to just know if they are likely to lose their hair sometime or not.

If you want a really knowledgeable answer from someone whos "involved" then you have a happy fun time waiting for it. Just dont bug me because i try to contribute my thoughts, maybe destroying your dream, just giving an opinion thou.

european is located in [NA] and he is available to meet: NO

baldbaby

09.10.2008, 22:51

@ dave21
HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn
Post reply

� And why is this only for women at the moment? :-|

probably because it involves a powerful anti-androgen drug.

anti-androgens are used for men, too, of course, but if one could be found that works for women in the form of a pill, it might regrow all the hair a woman lost.

if the same kind of powerful anti-androgen was given to a man in pill form, he'd probably grow breasts and get other female sex characteristics.

baldbaby is located in [NA] and he is available to meet: NO

baldbaby

10.10.2008, 00:21
(edited by baldbaby, 10.10.2008, 00:29)

@ european
it's not gene therapy....
Post reply

this is NOT gene therapy.

when ppl see "genetically" they automatically think "gene therapy"

but did they say anything about gene therapy? i think not....

they are using a term "genetically tailored", which could mean anything, and isn't really a widely used scientific term, as far as i can tell.

i think what they mean by "genetically tailored" is just that the pill or drug that they're gonna develop is targeted at whatever is wrong with the woman's genes -- e.g., she is positive for androgenetic alopecia (which in men, is mpb... in women it causes female pattern baldness).

this is not a outrageous development, pharma companies often tailor drugs to people's genes.

in fact if they know what is wrong with a person's genes, they can sometimes custom design a drug, by computer, that will fix the specific genetic fault.

maybe they're developing a custom drug that targets androgenetic alopecia, but is really only usable in women, because it's a potent anti androgen and if you give it to a man, he'd develop breasts, impotence, etc.

some guys are getting erectile problems and other bad side effects now from drugs like propecia and dutasteride. these side effects are usually mild.

i think they are designing this drug for women that will exactly target androdgenetic alopecia, which is the exact same set of genetic errors in men with male pattern baldness, only in female the hairloss is more diffuse. but it's the same gene.

now if you developed a very strong anti androgen, that will be powerful enough to not just stop hairloss and regrow some hair like finasteride or dutasteride do, but actually is strong enough to grow back most of the hair, are you gonna give this drug to a man????

no, if you slipped that drug to a man, there would be massive unwanted side effects...... sure, some men would want to take it just to get their hair back, but it would make them the equivalent of chemical eunuchs. very few men would want this.

but for women, it's a different story.

for instance i work with a woman who is about 53 and she has really serious androgenetic alopecia. she wears her hair long, too, down to her shoulders, but on the top it is extremely thin.

this kind of drug could really help her, because if she took it, she wouldn't mind the side effects, whatever they were. if her breasts grew bigger, i'm sure she'd like that... :-P

so that is what they mean by "genetically tailored"... it's just tailored to your genes, NOT changing your genes like a gene therapy would do.

an ya don't stop....

----

baldbaby. parlayin' to the ol skool beats since da 0-8.

baldbaby is located in [NA] and he is available to meet: NO

Dogstar 07.10.2008, 15:22	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn (Hair Multiplication & Research) Post reply
	http://www.marketwatch.com/news/story/hairdx-announces-clinical-trial-genetically/story.aspx?guid=%7B8BA640AC-998C-4B79-B4B8-39A9A9B18349%7D&dist=hppr I don't know if this will be beneficial to MPB but it maybe another step in that direction. Does anyone know the company that's involved and whether they are trustworthy or not. Dogstar is located in [NA] and he is available to meet: NO
mjones 07.10.2008, 16:06 @ Dogstar	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn Post reply
	� http://www.marketwatch.com/news/story/hairdx-announces-clinical-trial-genetically/story.aspx?guid=%7B8BA640AC-998C-4B79-B4B8-39A9A9B18349%7D&dist=hppr � � I don't know if this will be beneficial to MPB but it maybe another step � in that direction. � � Does anyone know the company that's involved and whether they are � trustworthy or not. That sounds like awesome news!! whatever it is its involving genes...so it must be related to MPB.... mjones is located in [NA] and he is available to meet: NO
dave21 07.10.2008, 16:52 @ mjones	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn Post reply
	And why is this only for women at the moment? dave21 is located in [NA] and he is available to meet: NO
european 07.10.2008, 19:33 @ dave21	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn Post reply
	� And why is this only for women at the moment? I think thats not really anything we should count on. HairDX is a company that sells a test to doctors which acts like a genetics screening for females and males to determine how much they are likely to lose their hair. So their business is most likely just to analyse genes, not to change them in any way (because thats really much much more difficult and would be revolutionary). So why it's only for women? I think because men already have finasteride. It sounds like all they intend to do is make a genetic screening and then give the woman a fitting therapy (like with topical spiro or whatever women use). ""Dermatologists often prescribe women drugs for the treatment of hair loss; however, only a fraction of women respond to the therapy. If the HairDX clinical trial proves successful, dermatologists will be able to individually tailor treatment for hair loss based on a woman's genetic makeup," said Professor Doron Lancet, Head of the Crown Human Genome Center at the Department of Molecular Genetics, Weizmann Institute of Science." Gene therapy is really far away for us balding guys, thats a fact to face, and HairDX won't really help us with that, except telling us how likely we are to go bald (which unfortunately doesnt change the outcome....) european is located in [NA] and he is available to meet: NO
Dogstar 07.10.2008, 21:39 @ european	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn Post reply
	� � And why is this only for women at the moment? � � I think thats not really anything we should count on. HairDX is a company � that sells a test to doctors which acts like a genetics screening for � females and males to determine how much they are likely to lose their hair. � � So their business is most likely just to analyse genes, not to change them � in any way (because thats really much much more difficult and would be � revolutionary). � � So why it's only for women? I think because men already have finasteride. � It sounds like all they intend to do is make a genetic screening and then � give the woman a fitting therapy (like with topical spiro or whatever women � use). � � ""Dermatologists often prescribe women drugs for the treatment of hair � loss; however, only a fraction of women respond to the therapy. If the � HairDX clinical trial proves successful, dermatologists will be able to � individually tailor treatment for hair loss based on a woman's genetic � makeup," said Professor Doron Lancet, Head of the Crown Human Genome Center � at the Department of Molecular Genetics, Weizmann Institute of Science." � � Gene therapy is really far away for us balding guys, thats a fact to face, � and HairDX won't really help us with that, except telling us how likely we � are to go bald (which unfortunately doesnt change the outcome....) Well there you go folks it's taken less than 24 hours for a person who isn't involved in anyway whatsoever to dismiss it, This is before we have any real facts about what it is they will be doing. Dogstar is located in [NA] and he is available to meet: NO
european 09.10.2008, 22:36 @ Dogstar	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn Post reply
	� � Well there you go folks it's taken less than 24 hours for a person who � isn't involved in anyway whatsoever to dismiss it, This is before we have � any real facts about what it is they will be doing. I didn't dismiss anything, i just shared my thoughts (read: "i THINK" in my reply). In such cases you just read over the article and make up your mind. In this case all i did was doing the maths. Face a few simple facts: - If they had a genetic "cure" in their hands, they would give a sht about women's hairloss, as they would as any company like to make some money. - Genetherapy just is something completely different then analysing genes. It takes the whole thing to a different level, and it is still in the beginning of development (how many working genetherapies which are really used do you know?) - just really READ the article and tell me where it says that they gonna CHANGE ANYTHING with the genes. All they do is supporting a Therapy based on the genes, that might me a really cool thing, but its no a breakthrough. - Why are women of special interest for this company? Maybe because most people they screen are women, as naturally women are more concerned about their looks than men (except gay men maybe) so they are more likely to pay a company money to just know if they are likely to lose their hair sometime or not. If you want a really knowledgeable answer from someone whos "involved" then you have a happy fun time waiting for it. Just dont bug me because i try to contribute my thoughts, maybe destroying your dream, just giving an opinion thou. european is located in [NA]* and he is available to meet: NO
baldbaby 09.10.2008, 22:51 @ dave21	HairDX Announces Clinical Trial Of Genetically Tailored Therapy for Female Baldn Post reply
	� And why is this only for women at the moment? probably because it involves a powerful anti-androgen drug. anti-androgens are used for men, too, of course, but if one could be found that works for women in the form of a pill, it might regrow all the hair a woman lost. if the same kind of powerful anti-androgen was given to a man in pill form, he'd probably grow breasts and get other female sex characteristics. baldbaby is located in [NA] and he is available to meet: NO
baldbaby 10.10.2008, 00:21 (edited by baldbaby, 10.10.2008, 00:29) @ european	it's not gene therapy.... Post reply
	this is NOT gene therapy. when ppl see "genetically" they automatically think "gene therapy" but did they say anything about gene therapy? i think not.... they are using a term "genetically tailored", which could mean anything, and isn't really a widely used scientific term, as far as i can tell. i think what they mean by "genetically tailored" is just that the pill or drug that they're gonna develop is targeted at whatever is wrong with the woman's genes -- e.g., she is positive for androgenetic alopecia (which in men, is mpb... in women it causes female pattern baldness). this is not a outrageous development, pharma companies often tailor drugs to people's genes. in fact if they know what is wrong with a person's genes, they can sometimes custom design a drug, by computer, that will fix the specific genetic fault. maybe they're developing a custom drug that targets androgenetic alopecia, but is really only usable in women, because it's a potent anti androgen and if you give it to a man, he'd develop breasts, impotence, etc. some guys are getting erectile problems and other bad side effects now from drugs like propecia and dutasteride. these side effects are usually mild. i think they are designing this drug for women that will exactly target androdgenetic alopecia, which is the exact same set of genetic errors in men with male pattern baldness, only in female the hairloss is more diffuse. but it's the same gene. now if you developed a very strong anti androgen, that will be powerful enough to not just stop hairloss and regrow some hair like finasteride or dutasteride do, but actually is strong enough to grow back most of the hair, are you gonna give this drug to a man???? no, if you slipped that drug to a man, there would be massive unwanted side effects...... sure, some men would want to take it just to get their hair back, but it would make them the equivalent of chemical eunuchs. very few men would want this. but for women, it's a different story. for instance i work with a woman who is about 53 and she has really serious androgenetic alopecia. she wears her hair long, too, down to her shoulders, but on the top it is extremely thin. this kind of drug could really help her, because if she took it, she wouldn't mind the side effects, whatever they were. if her breasts grew bigger, i'm sure she'd like that... so that is what they mean by "genetically tailored"... it's just tailored to your genes, NOT changing your genes like a gene therapy would do. an ya don't stop.... ---- baldbaby. parlayin' to the ol skool beats since da 0-8. baldbaby is located in [NA] and he is available to meet: NO