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07.10.2009, 21:34
 

Histogen Hair Stimulating Complex (HSC) 5-month result (Hair Loss Research & Clinical Trials)

Below is one of the slides in today's presentation by Dr. Gail Naughton. Self-explanatory.

Trial patient S1024
[image]

Better resolution photos of the same patient - trial patient S1024
[image]


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scarred1

07.10.2009, 22:07

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

I wonder why the terminal hair count diminished with time?


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Steve78

07.10.2009, 22:10

@ scarred1

Histogen Hair Stimulating Complex (HSC) 5-month result

» I wonder why the terminal hair count diminished with time?

Good question, the 5 months photos are clearly better than the 3 months, could that be a typo Hairsite?


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HairSite

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07.10.2009, 22:38

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

5 month photos of another trial patient.

Trial patient S1013
[image]


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Bd

07.10.2009, 23:19

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

This might be a stupid question, but.... Does anyone know roughly what a hair count would be in an area the size of a nickel on a normal head of hair? ie. How would the density compare to a person with a full head of hair.


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xbox360

07.10.2009, 23:26

@ Bd

Histogen Hair Stimulating Complex (HSC) 5-month result

» This might be a stupid question, but.... Does anyone know roughly what a
» hair count would be in an area the size of a nickel on a normal head of
» hair? ie. How would the density compare to a person with a full head of
» hair.

I dont know but I suppose the pic with 433 hair count x 4 would probably be a good estimate of what a normal full head of hair looks like, don't you think?


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Bd

08.10.2009, 01:37

@ xbox360

Histogen Hair Stimulating Complex (HSC) 5-month result

» I dont know but I suppose the pic with 433 hair count x 4 would probably
» be a good estimate of what a normal full head of hair looks like, don't you
» think?

Yeah, sounds like a reasonable amount.

Just read on another site that Histogen plan on trialing it in asia first with 300 participants. If the trial is successful, they want to release it in Asia afterwards, so no fda trials. Can Hairsite confirm if this information is correct?


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vivace67

Canada,
08.10.2009, 02:32

@ Bd

Histogen Hair Stimulating Complex (HSC) 5-month result

So, what's the next step here? It supposedly increases hair count, but does the hair stay forever? can this be applied to the rest of the scalp?


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rev

your nightmares,
08.10.2009, 03:41

@ vivace67

Histogen Hair Stimulating Complex (HSC) 5-month result

» So, what's the next step here? It supposedly increases hair count, but does
» the hair stay forever? can this be applied to the rest of the scalp?

This was summarized by someone else from another forum:
If the asian trial is succesful, they can go directly to market in asia, excluding Japan....no more waiting. Then they will look to the US.

They showed 2 photos at the 5 month mark with the average increase in hair being over 20% with a single injection.....some over 40%. The photos, like those seen on their website, are of an area the size a nickel. A 20% increase in this nickel sized area was equivalent to 100 additional hairs.

They say there were absolutely no safety issues and they feel like they can increase the effectivenes with multiple injections or by increasing the dosage.


The caveat
this was an investment raising presentation (it's expected they would) paint a very promising picture.

They are waiting for a ruling on their lawsuit motion for Summary Judgement. HSC is not a subject of the lawsuit.



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Bd

08.10.2009, 04:02

@ vivace67

Histogen Hair Stimulating Complex (HSC) 5-month result

» So, what's the next step here? It supposedly increases hair count, but does
» the hair stay forever? can this be applied to the rest of the scalp?

The new hair will almost certainly be susceptible to DHT. Histogen have admitted this, saying that "if it took 30 years for your old hair to fall out, it should take 30 years for the new hair to fall out". I am just speculating, but a way round this problem might be a top up every year to keep the new hair in a growth phase? We dont know, but this problem could be massive in terms of cost effectiveness ie. it costs a lot for hair thats gone in a few years.

I was wondering how HSC would act on the rest of the scalp aswell. We wont know until they start doing trials on the temples and front of the scalp. Maybe one of the guys on the site who are more knowledgeable than me could have a guess? I mean, will it give a hairline, or will an injection at the front lead to hair growing on your forehead.


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Van Halen

08.10.2009, 09:28

@ Bd

Histogen Hair Stimulating Complex (HSC) 5-month result

What's the point theses guys are at least 8- 10yrs away from market!


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TheOne

08.10.2009, 09:38

@ Van Halen

Histogen Hair Stimulating Complex (HSC) 5-month result

» What's the point theses guys are at least 8- 10yrs away from market!

Histogen them selves said them selves that the expected US release date if all goes well is 2015, so thats not 8-10 years away!

If you read up the page, it says they are planing an Asian clinical trial to possibly release even sooner.


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nsmnyc

08.10.2009, 10:28

@ TheOne

Histogen Hair Stimulating Complex (HSC) 5-month result

» » What's the point theses guys are at least 8- 10yrs away from market!
»
» Histogen them selves said them selves that the expected US release date if
» all goes well is 2015, so thats not 8-10 years away!
»
» If you read up the page, it says they are planing an Asian clinical trial
» to possibly release even sooner.

I have much respect for how Naughton runs her company, very well put together operation. Sad to say as I am from Canada orig, but I feel as if a few goons from Trick o science, have been posting on here, and it just makes me not like the co already.


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Leo2

08.10.2009, 10:29

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

I can't say I am not excited over these pictures, my only question is whether the 5month result is from just 1 injection?


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mjones

08.10.2009, 10:37

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

I am not impressed with these results at all....they still look bald to me...just a little more hair...actualy it just looks like the hair is longer in 5mth pic than from the initial....if u look at a guy with normal hair u can see his scalp even when its shaven down....i know this is maginified but still it doesnt impress me.....and 2015 fk it....6 yrs away....they will have some probs and discontinue it off the market just like every other drug...blah blah...merk wins again!!!


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HairSite

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08.10.2009, 10:46

@ Leo2

Histogen Hair Stimulating Complex (HSC) 5-month result

» I can't say I am not excited over these pictures, my only question is
» whether the 5month result is from just 1 injection?

Yes, the photos you see are the results from 1 injection only, including the 5 months'.


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BALDIE-IS-BACK-GO

08.10.2009, 10:57

@ mjones

Does it work on bald heads or just thinning hair?

I would of thought the big question is does it work on totally bald areas or just on thinning hair,as in photos.


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HMorHT

08.10.2009, 11:06

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

This is very promising if what we see if from 1 treatment only, but then the most important question as always is when will this hit the market? Someone in a previous post said they will introduce this in Asia first, is this true and when will it be available in the US?


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Steve78

08.10.2009, 12:15

@ HairSite

3 important questions

I think the 3 most important questions are

1) when
2) how much
3) explanation why terminal hair count diminished with time for one of the patient pics?


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BALDIE-IS-BACK-GO

08.10.2009, 12:55

@ Steve78

3 important questions plus 1 other question

» I think the 3 most important questions are
»
» 1) when
» 2) how much
» 3) explanation why terminal hair count diminished with time for one of the
» patient pics?

4) does it work on bald or balding (thinning hair) heads only or both?


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barnie

08.10.2009, 13:33

@ BALDIE-IS-BACK-GO

3 important questions plus 1 other question

» » I think the 3 most important questions are
» »
» » 1) when
» » 2) how much
» » 3) explanation why terminal hair count diminished with time for one of
» the
» » patient pics?
»
» 4) does it work on bald or balding (thinning hair) heads only or both?

We finally want answers, no longer questions!


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HairSite

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08.10.2009, 20:17

@ Steve78

WHEN

This is strictly from my recollection, please be advised that it may not be 100% accurate:

IF all goes as expected, there will be a pivotal trial in Singapore or somewhere in Asia approximately 6 months from now. The trial will focus on "Safety, Dosing & Delivery". It will be open to both men and women. Roughly 200-300 test subjects will be recruited.

A timeline was provided during the presentation yesterday. According to the chart, if everything goes well, official launch outside US "MIGHT" be possible in about 36 months from now.

This is for general discussion and speculation purposes only, not intended to be a promise that it will happen.


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JeepGuy

08.10.2009, 21:20

@ HairSite

WHEN

this must be a breakthrough, it is no longer 5 years away :)

» This is strictly from my recollection, please be advised that it may not be
» 100% accurate:
»
» IF all goes as expected, there will be a pivotal
» trial in Singapore or somewhere in Asia approximately 6 months from now.
» The trial will focus on "Safety, Dosing & Delivery". It will be open to
» both men and women. Roughly 200-300 test subjects will be recruited.
»
» A timeline was provided during the presentation yesterday. According to
» the chart, if everything goes well, official launch outside US
» "MIGHT" be possible in about 36 months from now.
»
» This is for general discussion and speculation purposes only, not intended
» to be a promise that it will happen.


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cal

08.10.2009, 21:34

@ JeepGuy

WHEN

my offhand thoughts on this:


-- Are the results compoundable? (if not then it's like minox. There's only a set 1-time gain despite repeatedly injecting the same area every few months.)


-- If we can't get it in the USA for a few years after asia, then surely we can find a way to get it imported under the table.


-- even w/o any improved DHT resistance compared to the originals, I hope the boosted hairs are able to survive PERIOD without constant re-injection. (If I could manage to get as much hair as I wanted, then surely I can walk away from all the medications for at least a few years, right?)


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HairSite

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08.10.2009, 21:45

@ cal

WHEN

» -- If we can't get it in the USA for a few years after asia, then
» surely we can find a way to get it imported under the table.


BTW, they are proceeding with the US trials too while the Asian trials are underway. If I recall correctly, and of course assuming all goes as planned, the timeline chart indicates that they expect to finish phase I and phase II trial in the US by the time they are ready for the official launch in Asia.


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debris

E-mail

09.10.2009, 02:44

@ Bd

Histogen Hair Stimulating Complex (HSC) 5-month result

» » I dont know but I suppose the pic with 433 hair count x 4 would
» probably
» » be a good estimate of what a normal full head of hair looks like, don't
» you
» » think?
»
» Yeah, sounds like a reasonable amount.
»
» Just read on another site that Histogen plan on trialing it in asia first
» with 300 participants. If the trial is successful, they want to release it
» in Asia afterwards, so no fda trials. Can Hairsite confirm if this
» information is correct?

you can easily estimate.

there is a scale. it looks to me like a circle of 0.8 cm in diameter (see the 2mm scale there?), so if its 0.8cm, then illusion of full head of hair density starts at 50*3 hairs / cm ^2. the area of the circle is pi*(0.8^2). The number of TERMINAL hair that would give you illusion of full head of hair would then have to be pi*(0.8^2)*50*3 and that is 301... with density of 70 grafts / cm^2 the number of terminal hair on the area of the size shown on the photographs would be pi*(0.8^2)*70*3 and that is 422 terminal hair.

You can see, that the person on the photograph started with quite a lot of hair already. He was far from slick bald. Yes some of it was not terminal, but still. My main concern would be, is this going to work for baldies? Or is it just another minoxidil that works if you still have your hair growing?

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nixi

09.10.2009, 06:12

@ barnie

3 important questions plus 1 other question

» » » I think the 3 most important questions are
» » »
» » » 1) when
» » » 2) how much
» » » 3) explanation why terminal hair count diminished with time for one
» of
» » the
» » » patient pics?
» »
» » 4) does it work on bald or balding (thinning hair) heads only or both?
»
» We finally want answers, no longer questions!

if you want an answer you need to know the question ;)


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pauly

09.10.2009, 10:35

@ HairSite

5 years

» » -- If we can't get it in the USA for a few years after asia, then
» » surely we can find a way to get it imported under the table.
»
»
» BTW, they are proceeding with the US trials too while the Asian trials are
» underway. If I recall correctly, and of course assuming all goes as
» planned, the timeline chart indicates that they expect to finish phase I
» and phase II trial in the US by the time they are ready for the official
» launch in Asia.

in other words, u.s release is still more or less 5 years away


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Mamoli

09.10.2009, 11:01

@ HairSite

Histogen Hair Stimulating Complex (HSC) 5-month result

Sorry I don't want to offend anybody but those "results" are 5000000 million years away from any cosmetic cure. Propecia or Minoxidil will give you better results.


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TheOne

09.10.2009, 11:05

@ pauly

5 years

» » » -- If we can't get it in the USA for a few years after asia, then
» » » surely we can find a way to get it imported under the table.
» »
» »
» » BTW, they are proceeding with the US trials too while the Asian trials
» are
» » underway. If I recall correctly, and of course assuming all goes as
» » planned, the timeline chart indicates that they expect to finish phase
» I
» » and phase II trial in the US by the time they are ready for the
» official
» » launch in Asia.
»
» in other words, u.s release is still more or less 5 years away

Why are people worried about a US release if they might release earlier in Asia?
If you could afford the $5000 dollars they plan to ask for the procedure, then surely you could stump up the money for some plane tickets.


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TheOne

09.10.2009, 11:07

@ Mamoli

Histogen Hair Stimulating Complex (HSC) 5-month result

» Sorry I don't want to offend anybody but those "results" are 5000000
» million years away from any cosmetic cure. Propecia or Minoxidil will give
» you better results.

You wont get results like this from one application of minoxidil or one propecia pill.

Why don't people take into account that these results were from a single injection?

For all we know results could improve drastically after a higher dosage or repeat injections, like so many other things do.


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xbox360

09.10.2009, 12:08

@ Mamoli

Histogen Hair Stimulating Complex (HSC) 5-month result

» Sorry I don't want to offend anybody but those "results" are 5000000
» million years away from any cosmetic cure. Propecia or Minoxidil will give
» you better results.

Been there, done that, Propecia and Minoxidil only help a little bit for me, I want to try something more effective before I consider hair transplant.


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FightingFalcon

09.10.2009, 15:39

@ Mamoli

Histogen Hair Stimulating Complex (HSC) 5-month result

» Sorry I don't want to offend anybody but those "results" are 5000000
» million years away from any cosmetic cure. Propecia or Minoxidil will give
» you better results.

Minoxidil only helps a small fraction of the people a little bit. And though it helps preserve hair, Propecia is almost useless for actually growing new hair.


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vivace67

Canada,
09.10.2009, 15:49

@ TheOne

5 years

» Why are people worried about a US release if they might release earlier in
» Asia?
» If you could afford the $5000 dollars they plan to ask for the procedure,
» then surely you could stump up the money for some plane tickets.

Sure - I would, but are the results permanent? We just don't have enough information...i would do anything to get off Propecia, which is an effective drug, but the side effects are HORRIBLE...


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---
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HairMax Laser Comb (use 3 times/week)
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"Hair Max" vitamin supplement (daily)

TheOne

09.10.2009, 18:45

@ vivace67

5 years

» » Why are people worried about a US release if they might release earlier
» in
» » Asia?
» » If you could afford the $5000 dollars they plan to ask for the
» procedure,
» » then surely you could stump up the money for some plane tickets.
»
» Sure - I would, but are the results permanent? We just don't have enough
» information...i would do anything to get off Propecia, which is an
» effective drug, but the side effects are HORRIBLE...

Are the results of Finasteride and Minoxidil permanent?...no


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cal

09.10.2009, 18:57

@ TheOne

5 years

»
» Are the results of Finasteride and Minoxidil permanent?...no


Minox has no permanence, I agree.

But Finasteride does. Use it (successfully) for 5 years, and you will probably push back your lifetime loss by most of 5 years permanently. Even if you drop the drug and the loss resumes, you will still retain the benefit from those 5 years for the rest of your life.


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hair101

Miami,
10.10.2009, 15:49

@ pauly

5 years

» in other words, u.s release is still more or less 5 years away

That's pretty much all I need to know for now. BTW the 5 month pics look very encouraging .


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hair101

Miami,
10.10.2009, 15:52

@ HairSite

test area is only 2mm?

I just noticed that at the bottom right hand corner of the pics, it reads "2mm", does it mean the test area is only 2mm in diameter? Can someone find out? 2mm is tiny, extremely tiny!


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---
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krapok

10.10.2009, 16:30

@ hair101

test area is only 2mm?

» I just noticed that at the bottom right hand corner of the pics, it reads
» "2mm", does it mean the test area is only 2mm in diameter? Can someone
» find out? 2mm is tiny, extremely tiny!

Look at the line above the 2mm number - i think 2mm is just the scale of that line. This means that the pic area is about 12x12mm in my opinion


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Spanish Dude

10.10.2009, 17:52

@ HairSite

Patient S1013 keeps improving at 5 months

» Below is one of the slides in today's presentation by Dr. Gail Naughton.
» Self-explanatory.
»
» Trial patient S1024
» [image]
»
» Better resolution photos of the same patient - trial patient S1024
» [image]

Well, these are 2 test subjects:
S1013 and S1024

They have different evolutions in time. The S1013 seems to have a sustained improvement in time, while the S1024 clearly loses steam at 5 months (terminal hairs number basically return to baseline at 5 months).

We will see. Patient S1013 makes me a bit optimistic. Maybe a finetuning will be able to improve the time-response in all patients...


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vivace67

Canada,
10.10.2009, 18:55

@ vivace67

5 years

»
» Sure - I would, but are the results permanent? We just don't have enough
» information...i would do anything to get off Propecia, which is an
» effective drug, but the side effects are HORRIBLE...

who the heck is going to get on a plane to SE Asia if the solution is not permanent? Surely, not I!

Propecia and Minoxidil are available at your local pharmacy, and have proven to slow down hair loss...

if you're goiong to make a rebuttal, make it a LOGICAL one


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---
Hair Regime

Propecia 1mg (daily)
5% Minoxidal (twice daily)
HairMax Laser Comb (use 3 times/week)
Nizoral Shampoo (about 3 times a week)
"Hair Max" vitamin supplement (daily)

tgates500

10.10.2009, 21:53

@ vivace67

5 years

» »
» » Sure - I would, but are the results permanent? We just don't have
» enough
» » information...i would do anything to get off Propecia, which is an
» » effective drug, but the side effects are HORRIBLE...
»
» who the heck is going to get on a plane to SE Asia if the solution is not
» permanent? Surely, not I!
»
» Propecia and Minoxidil are available at your local pharmacy, and have
» proven to slow down hair loss...
»
» if you're goiong to make a rebuttal, make it a LOGICAL one


you have a good point vivace....why would you go that far away without the proper clinical trials.

if you don't mind me asking, what are some of the side affects caused by propecia...I am currently using toppik which is nothing more than a cover up, but it does help for my self-steam


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vivace67

Canada,
10.10.2009, 23:32

@ tgates500

5 years

»
» if you don't mind me asking, what are some of the side affects caused by
» propecia...I am currently using toppik which is nothing more than a cover
» up, but it does help for my self-steam

i face the the most talked about side effects of propecia...it's utter BS that it only effects small percentage of users...

i'm seriously considering getting off propecia, but I'd go from NW 3 to NW5 probably within 8 months... i'll then just probably get a buzz cut ...i just can't bring myself to do - at least not yet!


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---
Hair Regime

Propecia 1mg (daily)
5% Minoxidal (twice daily)
HairMax Laser Comb (use 3 times/week)
Nizoral Shampoo (about 3 times a week)
"Hair Max" vitamin supplement (daily)

Steve78

11.10.2009, 21:47

@ Spanish Dude

Patient S1013 keeps improving at 5 months

i wonder if there is an explanation for that, patient s1024 hair count increases but both terminal hair and thickness decrease at 5 months. What's Histogen explanation and how many test patients are having this problem?


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fckhrls

11.10.2009, 23:17

@ Steve78

We can hardly conclude anything from two examples

» i wonder if there is an explanation for that, patient s1024 hair count
» increases but both terminal hair and thickness decrease at 5 months.
» What's Histogen explanation and how many test patients are having this
» problem?

Until the provide data with a sizable cohort, its hard to conclude anything from these two examples. I hope they can fund a full-fledged series of trials.


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Spanish Dude

12.10.2009, 09:51

@ fckhrls

We can hardly conclude anything from two examples

» » i wonder if there is an explanation for that, patient s1024 hair count
» » increases but both terminal hair and thickness decrease at 5 months.
» » What's Histogen explanation and how many test patients are having this
» » problem?

very weird. It seems that s1024 at 5 months started to lose thickness, and thus, some terminal hairs returned to vellus status. And additionally, new vellus hair was being created at 5 months... very weird.

»
» Until the provide data with a sizable cohort, its hard to conclude
» anything from these two examples. I hope they can fund a full-fledged
» series of trials.

true. s1013 has had a surprisingly good time response. He keeps improving even at 5 months. Too good to be true. Maybe this trialist secretly used minoxidil, hahaha.


Spanish Dude is located in [NA] and he is available to meet: NO

cal

14.11.2009, 18:57

@ Spanish Dude

We can hardly conclude anything from two examples

(bumping roger_that's threads off the bottom of the page)


cal is located in [NA] and he is available to meet: NO

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