Hair Loss Forum - Vitamin D3
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Robdan

17.02.2011, 15:12
(edited by Robdan, 17.02.2011, 15:36)
 

Vitamin D3 (Hair Loss Supplements)

Over the last twenty years I've lost about 50% of the hair on my head. I pretty much resigned myself to living without that hair.

I started taking 3,000 IU's of liquid vitamin D3 (gelcaps - daily) last fall to protect against the flu over the winter. I don't take any other vitamins or drugs and my life style hasn't changed since last fall. After about three and a half months, I surprisingly noticed that my hair is growing back at a rather rapid rate.

I checked the internet to see if there could be any connection between vitamin D3 and hair regrowth. I found the following information on a Dermatology Journal;

http://anagen.ucdavis.edu/1602/reviews/vitamind/rashid.html

It appears that the hair follicle needs a component within vitamin D3 to initiate the action that moves the follicle from the resting state to the growth state.

Not saying it will work for everyone else, but it's working for me.




Robdan is located in [NA] and he is available to meet: NO


Post reply
The Natural

17.02.2011, 22:03

@ Robdan

Vitamin D3

Thanks for sharing this.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
Mike1234

18.02.2011, 07:53

@ The Natural

Vitamin D3

ALL these Guys are setup by The Natual ... u gessed it right , he is a Lunatic , ... thinks "Royal Jelly " will grow him HAIR ..hahhaahhahahahahaha , it will only make his SH** smoother , he is totally insane , says VIT D will grow HAIR :-D , how funny .... why dont u post ANY PICS and prove ur sh**hole ...hahahahahhaha NUTS , and the Curry Powder ... did it go out of fashion? hahahahahhahahahahaha
Immortalhair site is a sick site , no real theroy , just stupid things to talk ... i even read someone talking some silly guy called CS , that what he shud do after his dad got a Heart attack ...hahahahhahahaha "GO TO THE DOCS" .... dont ask that silly CS .... use common sense , and to top it all the silly CS post his regimen ... to say his dad .....hahahhahahahahahhahahahahahahahahhahahahahahahhahahahahahaha
Totally a Lunatic site that just promotes Curry Powder . and they name it IH ... yeah Immortal Hair (Heart) .... take ur Pick ..... Natural is a Prick :)))))))))

Rgds

» Thanks for sharing this.




Mike1234 is located in [NA] and he is available to meet: NO


Post reply
Robdan

18.02.2011, 09:55

@ Mike1234

Vitamin D3

I really don't care whether you believe me or not. All I know is that for about the price of $8.00, somewhere between 5% - 10 % of my hair that was gone for many years has come back so far. Worst case scenario of giving it a try, is that your general health would probably improve.

» ALL these Guys are setup by The Natual ... u gessed it right , he is a
» Lunatic , ... thinks "Royal Jelly " will grow him HAIR
» ..hahhaahhahahahahaha , it will only make his SH** smoother , he is
» totally insane , says VIT D will grow HAIR :-D , how funny .... why dont u
» post ANY PICS and prove ur sh**hole ...hahahahahhaha NUTS , and the Curry
» Powder ... did it go out of fashion? hahahahahhahahahahaha
» Immortalhair site is a sick site , no real theroy , just stupid things to
» talk ... i even read someone talking some silly guy called CS , that what
» he shud do after his dad got a Heart attack ...hahahahhahahaha "GO TO THE
» DOCS" .... dont ask that silly CS .... use common sense , and to top it all
» the silly CS post his regimen ... to say his dad
» .....hahahhahahahahahhahahahahahahahahhahahahahahahhahahahahahaha
» Totally a Lunatic site that just promotes Curry Powder . and they name it
» IH ... yeah Immortal Hair (Heart) .... take ur Pick ..... Natural is a
» Prick :)))))))))
»
» Rgds
»
» » Thanks for sharing this.




Robdan is located in [NA] and he is available to meet: NO


Post reply
HanginInThere

Manila(UwishUrHere),
18.02.2011, 10:07

@ Robdan

Vitamin D3

» I really don't care whether you believe me or not. All I know is that for
» about the price of $8.00, somewhere between 5% - 10 % of my hair that was
» gone for many years has come back so far. Worst case scenario of giving it
» a try, is that your general health would probably improve.
»
» » ALL these Guys are setup by The Natual ... u gessed it right , he is a
» » Lunatic , ... thinks "Royal Jelly " will grow him HAIR
» » ..hahhaahhahahahahaha , it will only make his SH** smoother , he is
» » totally insane , says VIT D will grow HAIR :-D , how funny .... why dont
» u
» » post ANY PICS and prove ur sh**hole ...hahahahahhaha NUTS , and the
» Curry
» » Powder ... did it go out of fashion? hahahahahhahahahahaha
» » Immortalhair site is a sick site , no real theroy , just stupid things
» to
» » talk ... i even read someone talking some silly guy called CS , that
» what
» » he shud do after his dad got a Heart attack ...hahahahhahahaha "GO TO
» THE
» » DOCS" .... dont ask that silly CS .... use common sense , and to top it
» all
» » the silly CS post his regimen ... to say his dad
» » .....hahahhahahahahahhahahahahahahahahhahahahahahahhahahahahahaha
» » Totally a Lunatic site that just promotes Curry Powder . and they name
» it
» » IH ... yeah Immortal Hair (Heart) .... take ur Pick ..... Natural is a
» » Prick :)))))))))
» »
» » Rgds
» »
» » » Thanks for sharing this.

we all should supp our diet with this D3 for general health

whether it is capable of regrowing hair hmmm




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
Robdan

18.02.2011, 10:42
(edited by Robdan, 18.02.2011, 10:59)

@ HanginInThere

Vitamin D3

» » I really don't care whether you believe me or not. All I know is that
» for
» » about the price of $8.00, somewhere between 5% - 10 % of my hair that
» was
» » gone for many years has come back so far. Worst case scenario of giving
» it
» » a try, is that your general health would probably improve.
» »
» » » ALL these Guys are setup by The Natual ... u gessed it right , he is a
» » » Lunatic , ... thinks "Royal Jelly " will grow him HAIR
» » » ..hahhaahhahahahahaha , it will only make his SH** smoother , he is
» » » totally insane , says VIT D will grow HAIR :-D , how funny .... why
» dont
» » u
» » » post ANY PICS and prove ur sh**hole ...hahahahahhaha NUTS , and the
» » Curry
» » » Powder ... did it go out of fashion? hahahahahhahahahahaha
» » » Immortalhair site is a sick site , no real theroy , just stupid things
» » to
» » » talk ... i even read someone talking some silly guy called CS , that
» » what
» » » he shud do after his dad got a Heart attack ...hahahahhahahaha "GO TO
» » THE
» » » DOCS" .... dont ask that silly CS .... use common sense , and to top
» it
» » all
» » » the silly CS post his regimen ... to say his dad
» » » .....hahahhahahahahahhahahahahahahahahhahahahahahahhahahahahahaha
» » » Totally a Lunatic site that just promotes Curry Powder . and they name
» » it
» » » IH ... yeah Immortal Hair (Heart) .... take ur Pick ..... Natural is a
» » » Prick :)))))))))
» » »
» » » Rgds
» » »
» » » » Thanks for sharing this.
»
» we all should supp our diet with this D3 for general health
»
» whether it is capable of regrowing hair hmmm

Of course hmmmm - There is a multi-billion dollar hair restoration industry that hopes you won't try something so basic and inexpensive. If they told you what worked, their business would collapse within months.




Robdan is located in [NA] and he is available to meet: NO


Post reply
HanginInThere

Manila(UwishUrHere),
19.02.2011, 11:31
(edited by HanginInThere, 19.02.2011, 14:52)

@ Robdan

Vitamin D3

I just actually went to google and was surprised to find many articles in Vitamin D3 and Hair loss,

Have to order some and try it soon. I am a big believer in supps and Vit D3 was on my list even before this




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
silversurfer007

20.02.2011, 12:12

@ HanginInThere

Need Help!!

Can someone help me with this info...
Where can I buy MSM (and what brand) and Curcumin?I think the Natural
or Hanging once posted on this topic. Could you guys help me out please?

Thanks




silversurfer007 is located in [NA] and he is available to meet: NO


Post reply
HanginInThere

Manila(UwishUrHere),
20.02.2011, 12:31

@ silversurfer007

Need Help!!

» Can someone help me with this info...
» Where can I buy MSM (and what brand) and Curcumin?I think the Natural
» or Hanging once posted on this topic. Could you guys help me out please?
»
» Thanks

I live in Philippines so I cant buy at stores well I can and sometimes do but vitacost.com is a great online place

brands?
why are you taking MSM, for regrowth? it wont do that but it will improve the appearance shiny nature of your hair and healthy appearance

are you taking a super hair vit such as Maxi Hair or Ultra hair, and how about chelated mineral




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
silversurfer007

20.02.2011, 12:36

@ HanginInThere

Need Help!!

My regimen includes:
Taken
Mega Men Sport (GNC)
Acai with Green Tea
Vitaminc C 1000
Saw Palmetto
Biotin
Omega 3

Topical
Rogaine Foam
Nizoral

And I am looking to add in maybe the Curcumin or REsveratrol or MSM. I dont take all those supplements daily, I kind of mix them certain days, foe example one day abc, another day xyz.Most of them are with one day difference but I have seen a lot of improvement in my hair.




silversurfer007 is located in [NA] and he is available to meet: NO


Post reply
HanginInThere

Manila(UwishUrHere),
20.02.2011, 13:37

@ silversurfer007

Need Help!!

» My regimen includes:
» Taken
» Mega Men Sport (GNC)
» Acai with Green Tea
» Vitaminc C 1000
» Saw Palmetto
» Biotin
» Omega 3
»
» Topical
» Rogaine Foam
» Nizoral
»
» And I am looking to add in maybe the Curcumin or REsveratrol or MSM. I dont
» take all those supplements daily, I kind of mix them certain days, foe
» example one day abc, another day xyz.Most of them are with one day
» difference but I have seen a lot of improvement in my hair.

how is your hair doing now?
circ and resveratrol, I guess you could try them but they are a little bit wacked out as far as potential results IMO but who knows they might work on you

if you are taking all those supps I would definitely recommend adding Maxi Hair by Country life, its not expensive either

before i started on the dht blockers i was on only supps for years
and I would never go a day without my super hair vits at that time. You should be on 2000mcg Biotin and see what that does, (maxi hair has that too plus it has MSM and horsetail though not in the higher amounts)




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
silversurfer007

20.02.2011, 14:51

@ HanginInThere

Need Help!!

The truth is my hair is much better than before but I want to see if I can improve the results on my crown. I will lok into the Maxi Hair and the curcumin. The msm is not a 'proven' although it may help I will be happy with what is in the MAxi, on the other hand apparently curcumin has other side benefits that I might be perfect with.




silversurfer007 is located in [NA] and he is available to meet: NO


Post reply
HanginInThere

Manila(UwishUrHere),
20.02.2011, 15:26

@ silversurfer007

Need Help!!

» The truth is my hair is much better than before but I want to see if I can
» improve the results on my crown. I will lok into the Maxi Hair and the
» curcumin. The msm is not a 'proven' although it may help I will be happy
» with what is in the MAxi, on the other hand apparently curcumin has other
» side benefits that I might be perfect with.

crown now= ?
if its bald as in bald area that has been that way for a while, its very difficult IMO to get regrowth on those areas with ANY topical internal, supplement any drug, even with nizoral

if its thinning only , then there is a good chance to revive it
my thinning areas recovered like gangbusters
my bald spot on the crown did not respond to anything




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

20.02.2011, 19:59

@ silversurfer007

Need Help!!

» Can someone help me with this info...
» Where can I buy MSM (and what brand) and Curcumin?I think the Natural
» or Hanging once posted on this topic. Could you guys help me out please?
»
» Thanks


silversurfer,

I buy all of my supplements online at iHerb.com. Curcumin (turmeric root) should be taken with resveratrol as an effective treatment for scalp inflammation and thinning hair. You might try the following brands: Paradise Herbs, Jarrows.

MSM should be taken with vitamin C to improve absorption. As has been stated, it will improve the texture of your hair, may make it appear thicker. Nature's Way's brand was my choice.

TN




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
Mike1234

21.02.2011, 00:02

@ The Natural

Need Help!!

Silversurfer
Turmeric its root will Never Grow any hair , its just a Antispectic , which when used in Large dose will damage ur liver , as this is a Hair loss forum , its no use to post Turmeric ... as it ONLY GROWS HAIR FOR NATURAL IN HIS PANTS :))))))))):-D

» » Can someone help me with this info...
» » Where can I buy MSM (and what brand) and Curcumin?I think the Natural
» » or Hanging once posted on this topic. Could you guys help me out please?
» »
» » Thanks
»
»
» silversurfer,
»
» I buy all of my supplements online at iHerb.com. Curcumin (turmeric root)
» should be taken with resveratrol as an effective treatment for scalp
» inflammation and thinning hair. You might try the following brands:
» Paradise Herbs, Jarrows.
»
» MSM should be taken with vitamin C to improve absorption. As has been
» stated, it will improve the texture of your hair, may make it appear
» thicker. Nature's Way's brand was my choice.
»
» TN




Mike1234 is located in [NA] and he is available to meet: NO


Post reply
The Natural

21.02.2011, 03:48
(edited by The Natural, 21.02.2011, 04:04)

@ Mike1234

Need Help!!

Silversurfer,

You'll pardon the manners of this troll, Mike1234. English is his second language. He was banned at another forum for his imprudence. If he continues this behavior, he may find that he is banned from this site as well...

Turmeric or curcumin, by itself, will not do much, if anything, for your hair loss. Combined with resveratrol, however, the results of a clinical study were as follows:

"...while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too."




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
Mike1234

21.02.2011, 05:27

@ The Natural

Need Help!!

Hey Mr Natural , just a SINGLE SHORT TERM STUDY :))))) , use Beta Sitosterol and see so many studies , dont be a sales man for resveratrol and curcumin , it never grows Hair if it did these things are used in Indian Food since Centuries then why do we heave Bald men in India? hahahahahhahahaha

If u r so confident why dont u post some Photos? :)))))
Liar u know i was Banned from IM becos they too like yourself are selling this resveratrol and curcumin , u r all sales men , otherwise apart from u , who goes to IM its a silly site with NO Focus on Hairloss ...its Just BOGUS Like you are ...:-D

» Silversurfer,
»
» You'll pardon the manners of this troll, Mike1234. English is his second
» language. He was banned at another forum for his imprudence. If he
» continues this behavior, he may find that he is banned from this site as
» well...
»
» Turmeric or curcumin, by itself, will not do much, if anything, for your
» hair loss. Combined with resveratrol, however, the results of a clinical
» study were as follows:
»
» "...while the group treated with resveratrol and curcumin showed with great
» surprise a reduction, sometimes also relevant, in variable time periods.
» Moreover, during this testing, the patients treated with resveratrol and
» curcumin surprisingly showed positive improvements in the treatment of
» psoriasis and the attenuation and even a stop of the hair loss, a reduction
» of the hair graying and the rebirth of hair in bald areas sometimes even of
» the original color too."




Mike1234 is located in [NA] and he is available to meet: NO


Post reply
The Natural

21.02.2011, 06:56

@ Mike1234

Results

"...while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too."

Post your study potty mouth, Mike.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
21.02.2011, 08:50

@ The Natural

Results

» "...while the group treated with resveratrol and curcumin showed with great
» surprise a reduction, sometimes also relevant, in variable time periods.
» Moreover, during this testing, the patients treated with resveratrol and
» curcumin surprisingly showed positive improvements in the treatment of
» psoriasis and the attenuation and even a stop of the hair loss, a reduction
» of the hair graying and the rebirth of hair in bald areas sometimes even of
» the original color too."
»
» Post your study potty mouth, Mike.

The Natural (aka wuss) you call this cut and paste job "a study"
post the scientific journal it was published in, dates etc and also Who did the study




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

21.02.2011, 19:03

@ HanginInThere

Results from HanginInthere's Regimen

orrible: "I followed hangins regime after spending time on this forum in early 2005 and reading how naturals didnt give you side effects etc. I took beta sisterol, saw palmetoo & green tea extract in combination. After only 2 weeks i had developed gyne. I stopped the hairloss tabs and took anti estrogens but it didnt resolve. In the end i had surgery. I just thought i would post as i havent visited this forum in awhile and i would have appreciated learning about this before my disaster with naturals.

My link is below. If anybody takes the time to read through it you may see me refered to as stonecold. That was my old username on that forum, but i modified it to orrible to correspond with my hairloss forum username.

http://www.gynecomastia.org/smf/index.php/topic,3770.0.html"



Shall I continue, or have you learned your lesson?




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
The Natural

21.02.2011, 19:06

@ HanginInThere

Curcumin & Resveratrol Study

WO 2006087759 20060824

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called "French Paradox", that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral •

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

• preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called "Resverage". Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

- Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

- Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

- Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table n°1 shows the results obtained with the treatment with Resverage.


It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture n°1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
silversurfer007

21.02.2011, 20:02

@ The Natural

Curcumin & Resveratrol Study

Thanks for all the information guys. It has been vey useful. I will look more into it. Really useful information from everybody.




silversurfer007 is located in [NA] and he is available to meet: NO


Post reply
The Natural

21.02.2011, 20:33

@ silversurfer007

Curcumin & Resveratrol Study

» Thanks for all the information guys. It has been vey useful. I will look
» more into it. Really useful information from everybody.

More references here:


1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810449/

2. http://www.nutritionandmetabolism.com/content/5/1/17

3. http://www.wipo.int/pctdb/en/wo.jsp?wo=2006087759




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
22.02.2011, 11:51
(edited by HanginInThere, 22.02.2011, 15:59)

@ The Natural

cough cough that study is about cancer not hair loss

Nice try




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

22.02.2011, 19:34

@ HanginInThere

Study

» Nice try


That which causes cancer may also directly contribute to and/or accelerate one's hair loss. Didn't you know that?

But here is the hair loss study, again. This time, study it slowly old man:



PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called "French Paradox", that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral •

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

• preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called "Resverage". Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

- Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

- Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

- Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table n°1 shows the results obtained with the treatment with Resverage.


It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture n°1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
23.02.2011, 04:27
(edited by HanginInThere, 04.03.2011, 15:35)

@ The Natural

Phhhhht

Bunch of gibberish about Cancer prevention and curry powder and a few glancing mentions about hair loss

how about this
since your "study" so rarely mentions hair loss and we dont have the time or inclination to read all that crap

you go post the parts ABOUT HAIR LOSS in your "study"

also who did the study

its mostly a bunch of cancer prevention BS gobbledygook if you ask me




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

23.02.2011, 05:06

@ HanginInThere

Study

That which causes cancer may also directly contribute to and/or accelerate one's hair loss. Didn't you know that?

But here is the hair loss study, again. This time, study it slowly old man:



PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called "French Paradox", that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral ・

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

・preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called "Resverage". Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

- Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

- Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

- Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table nー1 shows the results obtained with the treatment with Resverage.


It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture nー1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
23.02.2011, 07:28
(edited by HanginInThere, 23.02.2011, 14:37)

@ The Natural

The natural, fabricating studies to support his claims

That which causes cancer may also directly contribute to and/or accelerate one's hair loss. Didn't you know that?

So, therefore you are implying that since your study , supposedly proves that curry powder is helpful in cancer prevention (unproven)
that it also helps with hair loss? ummmmmmmmmmmmm

So basically
1. the study you posted DID NOT SAY that curcumin and resveratrol stop hair loss, the study was about cancer:-P :-P

2. it made a glancing mention of hair loss (the study was not about hair loss)

3. so you had to INFER that since YOU THINK that cancer prevention is related to hair loss prevention, that MUST MEAN that the lame study you posted supports your theory that curcumin and Resveratrol prevent hair loss.



Thats also very sad and pathetic .:-P :-P :-D :-D ...........you having to twist the study results to say something that the study clearly did not say.........

course when push comes to shove and there are no studies to back up your claims, what other choice did you have? other than to make up Sh.it?

retardedEINSTEIN :-P :-P :-P :-P :-P :-P




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

23.02.2011, 20:03

@ HanginInThere

Study

That which causes cancer may also directly contribute to and/or accelerate one's hair loss. Didn't you know that?

But here is the hair loss study, again. This time, study it slowly old man:



PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called "French Paradox", that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral ・

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

・preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called "Resverage". Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

- Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

- Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

- Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table nー1 shows the results obtained with the treatment with Resverage.


It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture nー1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
The Natural

23.02.2011, 21:07

@ HanginInThere

Results from curcumin and resveratrol

"...while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too."




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
The Natural

24.02.2011, 20:37

@ HanginInThere

Male pattern baldness and the risk of prostate cancer

Ann Oncol. 2011 Feb 15.
Male pattern baldness and the risk of prostate cancer.
Yassa M, Saliou M, De Rycke Y, Hemery C, Henni M, Bachaud JM, Thiounn N, Cosset JM, Giraud P.

Department of Oncology Radiotherapy, European Georges Pompidou Hospital.

Background: Androgens play a role in the development of both androgenic alopecia, commonly known as male pattern baldness, and prostate cancer. We set out to study if early-onset androgenic alopecia was associated with an increased risk of prostate cancer later in life. Patients and methods: A total of 669 subjects (388 with a history of prostate cancer and 281 without) were enrolled in this study. All subjects were asked to score their balding pattern at ages 20, 30 and 40. Statistical comparison was subsequently done between both groups of patients. Results: Our study revealed that patients with prostate cancer were twice as likely to have androgenic alopecia at age 20 [odds ratio (OR) 2.01, P = 0.0285]. The pattern of hair loss was not a predictive factor for the development of cancer. There was no association between early-onset alopecia and an earlier diagnosis of prostate cancer or with the development of more aggressive tumors. Conclusions: This study shows an association between early-onset androgenic alopecia and the development of prostate cancer. Whether this population can benefit from routine prostate cancer screening or systematic use of 5-alpha reductase inhibitors as primary prevention remains to be determined.

Since we already know there is an association between MPB and insulin resistance, especially in early balding, I think it's clear that the risk factor prostate cancer simply increases with this factor. Cancer in general increases with insulin resistance.

5-alpha reductase inhibition is not the answer for prostate cancer prevention, because a metabolite of DHT is anti-carcinogenic. Ameliorating insulin resistance will reduce prostate cancer risks.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
25.02.2011, 06:21
(edited by HanginInThere, 26.02.2011, 02:33)

@ The Natural

The study is flawed

my brother got prostate cancer at 50 , his hair was not thinning at all


I knew another guy full head of hair 57 who got prostate cancer

I find it dubious to do a "study" on 1000 people and this study is indicative of billions of men all over the world

10,000 people maybe
but 1000? dont think so

I also find these "studies " to be very blind to contributing factors



What factors in their lives did these balding prostate cancer sufferers have that contributed to their risk of prostate cancer AND contributed to early balding?
THAT IS THE QUESTION THEY NEED TO ANSWER



Example lets say another study took these exact same 1000 men and said
Yes the prostate cancer sufferers , were twice as likely to begin balding at age 20

However we found that the early balding men, when isolated in the study
half the men also admitted they smoked 1-3 packs of cigarettes per day (3 x more likely )
lived basically on junk food and hated exercise

thats what I mean about taking into account contributing factors and looking at the entire picture, not just saying oh these early balding guys are more likely to get prostate cancer

unless they look only at the early balding men who got prostate cancer and rule out all other factors that they shared that may have increased their chances not only at balding but at getting prostate cancer, the study is meaningless at best




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

25.02.2011, 18:55

@ HanginInThere

Approaching Hair Loss

"Since we already know there is an association between MPB and insulin resistance, especially in early balding, I think it's clear that the risk factor prostate cancer simply increases with this factor. Cancer in general increases with insulin resistance.

5-alpha reductase inhibition is not the answer for prostate cancer prevention, because a metabolite of DHT is anti-carcinogenic. Ameliorating insulin resistance will reduce prostate cancer risks."

What posters here need to understand is that there is more to reducing hair loss and preventing cancer than just inhibiting DHT. We must look into treatments like chelation and reducing insulin resistance, as more effective long-term approaches to these diseases.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
26.02.2011, 03:51
(edited by HanginInThere, 26.02.2011, 04:49)

@ The Natural

The natural thinks this is a cancer forum

Newsflash its not

it is a hair loss forum

The natural, when asked to prove his regimen works, points to a cancer study that used his regimen and says , well since carcinogens tend to cause hair loss also, that means effective cancer treatments must also be effective hair loss treatments.

uh huh :-P :-P :-P :-D :-D




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

01.03.2011, 19:32

@ HanginInThere

The Results

"...while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too."

The results of a clinical study examining the effect curcumin and resveratrol have on male pattern baldness.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
02.03.2011, 09:36
(edited by HanginInThere, 02.03.2011, 14:00)

@ The Natural

What study? this is not legitimate

Most people who post studies also post all the details (medical journals dates NAME OF THE STUDY, by whom etc etc)

The only references in google to what you just pasted are in relation to a PATENT on a product. The "study" you refer to was vaguely referenced in their patent application.

How much you want to bet that this "study" was in fact fabricated , and it was done by the people applying for the patent? Gee what a surprise that would be. How convenient




If it were an actual double blind peer reviewed scientific study published in an approved medical journal, why did they not list the specs on the study? (by whom, what journal, what date, etc?)

Unless you can post proof that this "study" is legitimate, You just ended up with more egg on your face ....:-P :-P




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

02.03.2011, 18:47

@ HanginInThere

Study

A synergism does exist between curcumin and resveratrol. When used together, they can be an effective treatment against a variety of conditions, including but not limited to psoriasis and hair loss.


PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds, but also in a plant, the Polygonum Cuspidatum. Numbers of scientific researches have shown the in vitro efficacy of the Resveratrol in reducing the proliferation of human carcinogenic cells (Annals of the New York Academy of Science 957:210-229 (2002); Anticancer Res. 2004 Sept-Oct, 24(5A):2783-840; J Urol. 2002 Aug 168(2):748-55; Biochem Pharmacol 2004 Sep 15 68(6):1113-8; Drugs exp din Res 2003 29(5-6):257-61). Moreover, the regular use of red wine in France could explain the so-called "French Paradox", that is the low incidence of coronary diseases in French population even if its diet has a high fat content.

The researches carried out by D. Sinclair and others, published on the magazine NATURE ((2789-9/7/2004-VBCKNELL-111861), aroused great interest by considering the opportunity of a life extension in good conditions. The researches are based on data dated many years ago that showed that a controlled diet prolonged life of the Drosophila Melanogaster, even if as side effect the animal manifested drowsiness. It has been shown that the admixture of resveratrol to diet gives the same results of a controlled diet, but eliminating any negative side effect.

Moreover Sinclair, who discovered the ability of Resveratrol of prolonging the life of yeasts, tried it on fruit-flies and small worms that have biological processes similar to the human ones. He ascertained an increased activity and fertility, together with a greater egg production. Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its

diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The authors of the present invention, starting from the recognized anti-inflammable and anti-neoplastic action of resveratrol and curcumin, have tested two mixtures with an antioxidant action. The first one is made of basically resveratrol (called Resverage) and the other one made of resveratrol and curcumin (called Capsures). The mixtures have been packaged in capsules for oral use. At the beginning the compounds have been administered to patients with prostate carcinoma insensible to hormones. The choice of these patients depends of the fact that the evolution of neoplasia can easily be monitored by the prostate-specific antigens (PSA).

The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too. This aspect polarized the attention and the mechanism that ruled the association of the two substances became the object of the studies. The physic and pathologic basis of the action of the association of resveratrol and curcumin can be found in the relationship existing between the congenital hyposensitization of the sensory fibers of rats and the skin lesions similar to psoriatic lesions. In that case, the administration of a substance that reactivates the skin tropism would open new ways to the treatment of skin lesions.1A possible theory is that it is possible to stimulate the peripheral ・

sensory fibers with tropic function by associating curcumin and resveratrol. Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

Figure 1 shows a scheme of the capsaicin-sensible sensory neuron and the localization of tackykinins (P substance and Neurokinin A) and CGRP with the receptors TRPV 1. The scheme would show the double function, afferent and efferent, of the sensorial fibers with the release of neuropeptides from the terminal like the P substance, Neurokinin A and CGRP (Calcitonin gene related peptides). Researches are progressing about the use of high dosages of Curcumin for the treatment of colon cancer, but it seems like any effect on the hair growth has been shown; Effect that instead has been obtained thanks to the administration of curcumin together with resveratrol.

Therefore, the object of the present invention is a pharmaceutical composition comprising resveratrol and/or the root of polygonum cuspidatum, containing resveratrol, and curcumin and/or root of the curcuma longa, containing curcumin, as active principles, in association with one or more adjuvant and/or excipients pharmacologically acceptable. The root of powdered polygonum cuspidatum, a plant commonly used in the traditional Chinese and Japanese medicine as circulatory tonic, is particularly rich in resveratrol. Epidemiological and in vitro studies suggest that its use reduces the incidence of cardiovascular diseases and cancers. The powdered root of Curcuma longa, a plant diffused in the oriental medicine, is very rich in active elements as curcuminoids, the elements responsible for the characteristic yellow color and probably for the anti-inflammatory, antiviral and detoxicant effects too.

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

Moreover, according to the invention, the pharmaceutical composition can also comprise vitamin C and/or berries of Rosa canina containing vitamin C. In fact the powdered berry of Rosa canina is a natural source of C vitamin, important for the good functioning of the immune system and an excellent antioxidant too. The vitamin C fights any kind of infection and facilitates the repair of the connective tissue. The modern living conditions, the high level of air pollution, smoking and passive smoking, increase our need of vitamin C.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg,

・preferably from 100 to 350 mg; of powdered berries of Rosa canina from

50 to 450 mg, preferably from 100 to 350 mg; of the powdered fruit of capsicum annum from 50 to 450, preferably from 100 to 350 mg; of the powdered root of curcuma longa from 1 to 100 mg, preferably from 50 to 100 mg; of the powdered root of polygonum cuspidatum from 1 to 100 mg, preferably from 50 to 100 mg.

The abovementioned quantities are the quantities contained in one dosage unit. According to a preferred embodiment of the invention, the composition comprises Rosa canina (titrated dried extract) 10%; natural vitamin C 150.00 mg.; synthetic vitamin C 15.00 mg; Curcuma (titrated dried extract) 95%; Curcumin 20.60 mg; synthetic Curcumin 20.00 mg; Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg; synthetic resveratrol 5.00 mg.; wheat germ oil 60.00 mg.; Capsicum (titrated dried extract) 60% in capsaicin 5.00 mg.; synthetic capsaicin 3.00 mg.

T/IT2006/000093

5

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

It is understood that the abovementioned examples are just an exemplification offered to illustrate the practical usages of the invention.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

The present invention will now be described by way of information, not restrictively, in its preferred ways of presentation, with a particular reference to the attached pictures, where:

Figure 1 shows a scheme of the capsaicinoids-sensible sensory neuron, and the localization of tackykinins (substance P and Neurokinin A) and CGRP with the receptor TRPV 1.

Example 1 : Study on the effect of resveratrol and the association of resveratrol and curcumin on the prostate-specific antigen (PSA) in patients affected by prostate carcinoma, on hair growth and on psoriasis.

A composition has been prepared. It contains RESVERATROL (poligonum cuspidatum) and other antioxidants and it is called "Resverage". Its ingredients are: Rosa canina (titrated dried extract) 10%; natural vitamin C 200.00 mg; synthetic vitamin C 20.00 mg; wheat germ oil 60.00 mg; poligonum cuspidatum (titrated dried extract) 98%; resveratrol 8.20 mg; synthetic resveratrol 8.00 mg. The administration capsules of this composition to 5 patients did not give any positive result. Thus, another

composition containing resveratrol and curcumin (Curcuma longa) has been prepared and tested on a bigger group of patients. In detail the composition was composed of:

- Rosa canina (titrated dried extract) 10%, natural vitamin C 150.00 mg., synthetic vitamin C 15.00;

- Curcuma (titrated dried extract) 95%, Curcumin20.60; synthetic Curcumin 20.00 mg

- Poligonum cuspidatum (titrated dried extract) 98%; resveratrol 5.10 mg.; Synthetic resveratrol 5.00 mg - Wheat germ oil 60.00 mg, capsicum (titrated dried extract)

60% in capsaicin 5.00 mg; synthetic capsaicin 3.00 mg.

Ingredients: dicalcic phosphate, fruits of rosa canina (titrated dried extract) maltodextrins 10%; natural vitamin C, wheat germ oil plv titrated 40%(triticum vulgaris, modified amylum, microcrystalline cellulose, Curcuma rhizome (titrated dried extract)Curcuma Longa L. maltodextrins 95%; Curcumin, anti-agglomerative, vegetal stearate magnesium; coating agents: hydroxyl-propyl-methyl cellulose, glycerol, titanium dioxide; Capsicum fruit (titrated dried extract) [capsicum frutescens, capsicum annum) 60% in capsaicin, Poligonum Cuspidatum root (dried extract) 98%, resveratrol.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing. MATERIALS AND METHODS

The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

Group treated with resveratrol: 5 patient, aged between 64 and 76 years old, affected by a hormone-independent prostate carcinoma have been treated with Resverage, 4 pills a day, for a period that ranged from 30 and 90 days. The basic PSA varied from 25/220 mg/ml and it has been monitored for the 15 days following the treatment period. The patients tolerated the therapy without showing any nuisance. Table nー1 shows the results obtained with the treatment with Resverage.


It is demonstrated that hair has a sensory innervation defined capsaicin-sensitive, whose characteristic is that the C-amyelinated fibers have an afferent and efferent function (see scheme of picture nー1).

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
02.03.2011, 20:09
(edited by HanginInThere, 02.03.2011, 20:34)

@ The Natural

You just proved my point

.......................................................................................................................................................................................» Group treated with resveratrol: 5 patient, aged between 64 and 76 years
an important role of the P substance on the hair growth in vivo.

not much more to say on that LOL

FIVE PATIENTS and you call this a study?

Needless to say this proves my point, this is not a "study":-P :-P :-P




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

02.03.2011, 22:38

@ HanginInThere

Plan B

"Group treated with curcumin e resveratrol 20 patients, some of them affected by prostate neoplasia and/or by hair loss, treated with curcumin and resveratrol for a period ranging from 30 days to 6 months...As far as the action on hair is concerned, it is unquestionably due to the administration of the two combined active elements, since in the compound with just resveratrol no result has been shown and in the many cases in India and in Europe where Curcumin has been employed, any effect on hair has never been reported. The most important aspect rarely highlighted is that curcuminoids are capsaicinoid substances."

And some of these patients were in their 60s! So instead of fighting with me, why don't you try curcumin and resveratrol. Your DHT blockers have done nothing but make you a very grumpy old man with a bald crown.

Time for Plan B, Huckleberry.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
03.03.2011, 02:20
(edited by HanginInThere, 03.03.2011, 08:24)

@ The Natural

the Natural is rapidly approaching NW 5 to 6

The Natural I feel sorry for you. Its sad really, your brain cells seem to have washed down the sink with what is left of your hair.

I am you and the other board members in 20 yrs

the big difference Is I still have my hair 90 percent of it.
You and most of the other board members , in 20 yrs hair will be a distant memory for you

I sincerely hope you find SOMETHING that works for you. I know you are now clinging to curcumin and Resveratrol. I wish you luck

:-P :-P

You and Nick cage have a lot in common, apparently

[image]

[image]




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

03.03.2011, 21:03

@ HanginInThere

Old and grumpy

Your crown is bald, sir. And no one believes that you can maintain the rest of your hair on saw palmetto and beta sitosterol :no: . That is why you left the other forum. Folk there got tired of your lies.




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
04.03.2011, 05:51

@ The Natural

Hoy Nic cages Twin

Bald spot on crown = way better than your situation. As I said you and Nick cage are pretty much at the same level of baldness , ....NO? then

Prove me Wrong

Post your Pictures Bigshot

Oh, cough cough you dont own a camera right?

[image]

stop desperately trying to get others to follow your bogus regimen. You see anyone here swallowing your tales ? I dont

go back to "that other forum" where everyone drinks the koolaide :-P :-P :-P




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

04.03.2011, 21:57

@ HanginInThere

Belief

1. You are 60 years old.
2. Your crown is completely bald.
3. Nobody is impressed with your combover.
4. Jacob stated that your pictures were of different people.
5. I believe him :yes: .

I am starting to hear your greatest hits again in the background...




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
05.03.2011, 01:53
(edited by HanginInThere, 05.03.2011, 02:16)

@ The Natural

get a grip man

1. you are 90 percent bald. Me? i have a small bald spot on the crown.

I prefer older with a small bald spot than younger and almost bald.,and broke...(like you) :-P :-P

what advantage is being younger? if you are unemployed no money no job no girlfriend, live with your parents, and NW6? Just sayin............:-D :-D :-D :-D


2. you are desperately clinging to a regimen that cannot grow hair on a dog much less a human
3. you hang out on "the other board" because nobody there has the brains god gave a goat, and they just swallow anything people dish out

4 nobody on this board listens to your regimen. Do you see anyone following it?
:-P :-P :-P :-P :-P

5. you cannot get a date and you are horrified that you might never have a family get married and be a real man so you cling to any ridiculous regimen hoping women will think you are a stud one day. Good luck with that

by the way, my age? none of your concern but if you want a hint, I stormed the beaches at Normandy France in WW2, while you were not even a gleam in your grandmothers eye

Pictures , my pictures you say? funny you should mention pictures
COWARD

Did you scrape up enough money to buy a digital camera yet?
:-D :-D :-D :-D

I tell you what, I feel sorry for you, give me your address and I will send you my old digital camera that my kids are using. that way you dont have to try to borrow more money from your parents.




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

05.03.2011, 05:09

@ HanginInThere

The End of HanginInThere

1. Your crown is completely bald.
2. You are a sixty-something year old man with a penchant for taking advantage of foreign woman who would do just about anything to better their present predicament. It's sad, and I am not impressed.
3. Spend much of your day arguing with men half your age about a subject that you know far too little. Namely, how to stop hair loss. Your DHT blockers have done nothing for that hole in the back of your head, sir.
4. Jacob caught you in a lie.
5. Jacob caught you in a lie. Those were not your pictures.
6. Jacob caught you in a lie. Those were not your pictures. They were of two different people :yes: .
7. People do not believe you when you state that you have maintained your hair with just saw palmetto and beta sitosterol. It is a lie. You keep changing your story, Buckwheat, telling people to use vitamins and minerals, but you don't even use them.
8. Many people here and at other forums are using curcumin and resveratrol, successfully. Get your facts straight, grand pa. And keep your old ass out of IH's forum, Hair Loss Talk, Hair Loss Help, and Regrowth. They will laugh at you and your 1990's hair loss regimen. This is 2011, wake up!
9. I hear your hits in the background...




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
05.03.2011, 05:34
(edited by HanginInThere, 05.03.2011, 17:16)

@ The Natural

so i guess you dont want me to give you a digital cam?

1. you are in your late 30s or early 40s

2. you have no job
3. you live with your parents
4. you are calling my pics fake without seeing them

5. you are deathly afraid to post your own pics thus the i dont have a camera lie
:clap: :no: :lol3:

6. you hang out on the other forum because, well thats the only place where people are dumb enough to believe curry powder works for hair loss. Course that could be because half the board there are indian cooks in training:hungry:

7. your hair is WAY worse than mine and you are 10 yrs younger than me:lol2: :lol2:

8. you claim you know what you are talking about? about bankruptcy maybe. About hair loss, thats a laugh

9. you took your sister to prom
10. she still remembers the night fondly:-P :-P




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

05.03.2011, 18:37

@ HanginInThere

HanginInThere's Oldies

Hairsite: "Hanging please leave forum members alone."

rev: "...you talk too much for a guy that knows too little."

Widowspeak: "More of the same babble from Mr. KnowItAll, a.k.a. HanginNoWhere. Hangin's one of the reasons I don't post here like I used to.
No drugs, rugs or plugs....beta-sis."

HanginInThere: "I do not like my pics being up permanently online, Jacob got mad because he had not saved them yet, so he started making up all kinds of conspiracy fake pic stories."

Jacob: “Wrong. You took the pictures down because personal information was on the one. All of yours were not of the same person. THAT is why you took them down.”

Widowspeak: "If you don't pretend [HanginInThere] is relevent to this site or tell him you achieved regrowth with his so-called "advice" you will be attacked just like he attacks my posts and accuses me of being someone else."

The Natural is right. Hangin is ALWAYS the common denominator where there's trouble. Now Hangin will proceed to "put me in my place" and then call me Kramer."

mj2003: "Natural, I ignored the prick when [HanginInThere] directly insulted me out of the blue. You can do the same.

The internet is a funny place. It's kind of like the US Army.... "Be All You Can Be". Everyone sits behind a computer with multiple phd's and such vast experience these days, but the one thing they seem to lack is Human-Correspondence 101.

Best of luck."

orrible: "I followed hangins regime after spending time on this forum in early 2005 and reading how naturals didnt give you side effects etc. I took beta sisterol, saw palmetoo & green tea extract in combination. After only 2 weeks i had developed gyne. I stopped the hairloss tabs and took anti estrogens but it didnt resolve. In the end i had surgery. I just thought i would post as i havent visited this forum in awhile and i would have appreciated learning about this before my disaster with naturals.

My link is below. If anybody takes the time to read through it you may see me refered to as stonecold. That was my old username on that forum, but i modified it to orrible to correspond with my hairloss forum username.

http://www.gynecomastia.org/smf/index.php/topic,3770.0.html"

Hogan: (reply to HanginInThere)"...why I would be jealous of a mentally retarded, balding, 40-something, with no degree, living in the the Philippines? LOL"

Hairoine: "Just wondering if your hair looks so good then why do you bother coming on this board?"

HanginInThere: "I come...because I am bored."

Hairoine: "Oh right. You do realise though that now no one will listen to anything you say. Am not having a go but if your bored that surely the only reason you come on this part of the forum is to wind people up?

If you have more knowledge than the guys on here and they are not willing to listen then why bother posting anything? I would just let people get on with whatever they want to do and if anyone comes directly to you for help then go for it."

yellbird: "Mental Wards are full of Bored people like him. As the Doctor entered the room he asked how you doing. The reply was I am HANGINTHERE Doc."

thegreek: [HanginInThere] all your threads end up offtopic or deleted... You are so freaked out that everybody understood what an idiot you are that you try to fill the place with stupid threads.

It will end up offtopic as well... you are the forum clown and you know you cannot change it, pretty soon you are going to freak out completely and fill the forum with BS threads..."

Every village has an idiot...you are officially our idiot."

Hogan: "All of my supporters have regrown their hair and have moved on with their lives. Not hangin(there) around some bulletin board. Unlike some who seek any attention that they can get from any stranger that is willing to flatter them. Get a life.

I haven't posted on this board for the last year and a half because I have been busy working on my MBA, something you will never have. While you have been busy pitching your horrible regimen on un-suspecting noobs, I have gotten an MBA.

You live a sad, sad life. The only existence you have is on this board."

The Natural: "Most men are sensitive about their hair or lack thereof."

HanginInThere: "most of us are fine with it then you have crybabies like the natural .................."

Willy: "Hangin, You're so fine with it that you post more than anyone on Hairsite EVERYDAY!!! P L E A S E ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !"

ApeSmith: “Hanging, even if someone does not provide proof of their regrowth, hey wish them well and good luck and be on your merry way, there is no need for bitterness and acting pathetic.”

Jtelecom: "Hangin, You need some serious help, man! I think that you should talk to somebody about your feelings on these (and other) issues. These rants of yours are not doing you or anybody any good. Get some help - NOW!"

And the hits keep rolling and rolling! :rotfl:




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
HanginInThere

Manila(UwishUrHere),
06.03.2011, 00:30

@ The Natural

The natural surrenders, he is done

Just get it over with and admit you lose..........................

oh and that you are a loser

GAME
SET
MATCH
:clap: :clap: :clap:




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply
The Natural

06.03.2011, 19:12

@ HanginInThere

HanginInThere's Oldies but Goodies

Hairsite: "Hanging please leave forum members alone."

rev: "...you talk too much for a guy that knows too little."

Widowspeak: "More of the same babble from Mr. KnowItAll, a.k.a. HanginNoWhere. Hangin's one of the reasons I don't post here like I used to.
No drugs, rugs or plugs....beta-sis."

HanginInThere: "I do not like my pics being up permanently online, Jacob got mad because he had not saved them yet, so he started making up all kinds of conspiracy fake pic stories."

Jacob: “Wrong. You took the pictures down because personal information was on the one. All of yours were not of the same person. THAT is why you took them down.”

Widowspeak: "If you don't pretend [HanginInThere] is relevent to this site or tell him you achieved regrowth with his so-called "advice" you will be attacked just like he attacks my posts and accuses me of being someone else."

The Natural is right. Hangin is ALWAYS the common denominator where there's trouble. Now Hangin will proceed to "put me in my place" and then call me Kramer."

mj2003: "Natural, I ignored the prick when [HanginInThere] directly insulted me out of the blue. You can do the same.

The internet is a funny place. It's kind of like the US Army.... "Be All You Can Be". Everyone sits behind a computer with multiple phd's and such vast experience these days, but the one thing they seem to lack is Human-Correspondence 101.

Best of luck."

orrible: "I followed hangins regime after spending time on this forum in early 2005 and reading how naturals didnt give you side effects etc. I took beta sisterol, saw palmetoo & green tea extract in combination. After only 2 weeks i had developed gyne. I stopped the hairloss tabs and took anti estrogens but it didnt resolve. In the end i had surgery. I just thought i would post as i havent visited this forum in awhile and i would have appreciated learning about this before my disaster with naturals.

My link is below. If anybody takes the time to read through it you may see me refered to as stonecold. That was my old username on that forum, but i modified it to orrible to correspond with my hairloss forum username.

http://www.gynecomastia.org/smf/index.php/topic,3770.0.html"

Hogan: (reply to HanginInThere)"...why I would be jealous of a mentally retarded, balding, 40-something, with no degree, living in the the Philippines? LOL"

Hairoine: "Just wondering if your hair looks so good then why do you bother coming on this board?"

HanginInThere: "I come...because I am bored."

Hairoine: "Oh right. You do realise though that now no one will listen to anything you say. Am not having a go but if your bored that surely the only reason you come on this part of the forum is to wind people up?

If you have more knowledge than the guys on here and they are not willing to listen then why bother posting anything? I would just let people get on with whatever they want to do and if anyone comes directly to you for help then go for it."

yellbird: "Mental Wards are full of Bored people like him. As the Doctor entered the room he asked how you doing. The reply was I am HANGINTHERE Doc."

thegreek: [HanginInThere] all your threads end up offtopic or deleted... You are so freaked out that everybody understood what an idiot you are that you try to fill the place with stupid threads.

It will end up offtopic as well... you are the forum clown and you know you cannot change it, pretty soon you are going to freak out completely and fill the forum with BS threads..."

Every village has an idiot...you are officially our idiot."

Hogan: "All of my supporters have regrown their hair and have moved on with their lives. Not hangin(there) around some bulletin board. Unlike some who seek any attention that they can get from any stranger that is willing to flatter them. Get a life.

I haven't posted on this board for the last year and a half because I have been busy working on my MBA, something you will never have. While you have been busy pitching your horrible regimen on un-suspecting noobs, I have gotten an MBA.

You live a sad, sad life. The only existence you have is on this board."

The Natural: "Most men are sensitive about their hair or lack thereof."

HanginInThere: "most of us are fine with it then you have crybabies like the natural .................."

Willy: "Hangin, You're so fine with it that you post more than anyone on Hairsite EVERYDAY!!! P L E A S E ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! ! !"

ApeSmith: “Hanging, even if someone does not provide proof of their regrowth, hey wish them well and good luck and be on your merry way, there is no need for bitterness and acting pathetic.”

Jtelecom: "Hangin, You need some serious help, man! I think that you should talk to somebody about your feelings on these (and other) issues. These rants of yours are not doing you or anybody any good. Get some help - NOW!"

And the hits keep rolling and rolling! :rotfl:




The Natural is located in [NA] and he is available to meet: NO

---
The Natural Internal Regimen

mornings - vitamin C + aged garlic extract; mid-mornings - curcumin (Meriva) + cayenne pepper/ginger; afternoons - algae extract; bedtime - MSM (OptiMSM)


Post reply
joshuawilson

New York,
28.07.2011, 13:10

@ The Natural

Vitamin D3

» Thanks for sharing this.


Well,, every product have some bad effects. before taking such medicines do a person need to check up for something so that D3 intake donot turn into bad for hair or body.....




joshuawilson is located in NEW YORK and he is available to meet: NO


Post reply
HanginInThere

Manila(UwishUrHere),
19.08.2011, 17:43

@ The Natural

The Naturals newbies and every day whining

Ever notice that whenever the natural gets his ass kicked in an argument
he posts "hangins Hits"

guess that means he gets his ass kicked regularly, :clap:




HanginInThere is located in MANILA(UWISHURHERE) and he is available to meet: YES
email hairsite@aol.com to arrange a meeting.

---
Recommended Hangin Regimen
Maxi Hair by Country Life 2/day
Saw Palmetto 320mg/day
Beta Sitosterol 125mcg/day
Pygeum 500/day
Nettles 500/day
Kal Amino Max 2/day


Post reply

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