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My research - now please share yours! (Propecia, Spiro, DHT & hormones ...)

posted by gc1961, 31.08.2007, 10:13

» » » 17-Estradiol Induces Aromatase Activity in Human Hair Follicles
» » » Dept of Derm, Philipp University, Marburg, Germany
» » »
» » » "...Our results suggest that under the influence of 17 a-Estradiol an
» » » increased conversion of testosterone to 17 b-estradiol and
» » androstendione
» » » to estrone takes place. In theory this pathway may diminish the
» amount
» » of
» » » intrafollicular testosterone available for conversion to DHT, ane
» » because
» » » DHT is the major mediator of AGA, this pathway may explain the
» » beneficial
» » » effect of 17 a-estradiol on the development and progression of AGA."
» »
» »
» » I don't really buy the last sentence. All the recent reseach shows that
» E
» » is as bad for hair and prostate as DHT. I think they made too much of a
» » jump in their conclusion. A definite case of separating the science
» » results from a bad interpretation.
»
» There's a lot of speculation about the role of estrogen in the etiology of
» prostate disease (even though a study testing an aromatase inhibitor for
» BPH found no effect), but I'm deeply puzzled by your claim that "all the
» recent research" shows that E is bad for hair. I'd really appreciate it
» if you could cite that recent research for me! :-)
»
» Bryan
 \

My Primary Ref.

The Hair Follicle as an Estrogen Target and Source
Ohnemus, Uenaian, Inunza, Gustafson, Paus
University of Hamburg & Karobio
2006

This paper is a round-up of Estrogen research and references 375 other research papers; it gives a good overview and discusses Estrogen inhibition of Androgen. It also covers the latest on ER-alpha and ER-beta receptors and their different characteristics.

There is a lot of work on Estrogen in various cancers (prostate and breast); hence the industry focus on SERMs and the current use of Tamoxifen. In the natural space there is a lot of research on I3C and DIM in the Estrogen matabolism.

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