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My research - now please share yours! (Propecia, Avodart, Spiro, DHT & hormones ...)

posted by Bryan, 03.09.2007, 08:18
(edited by Bryan on 03.09.2007, 08:43)

» My Primary Ref.
»
» The Hair Follicle as an Estrogen Target and Source
» Ohnemus, Uenaian, Inunza, Gustafson, Paus
» University of Hamburg & Karobio
» 2006
»
» This paper is a round-up of Estrogen research and references 375 other
» research papers; it gives a good overview and discusses Estrogen
» inhibition of Androgen. It also covers the latest on ER-alpha and ER-beta
» receptors and their different characteristics.
Ok, I just got that paper from the med library last night, and I've now finished reading it!

There's nothing in the paper which conflicts with what I said before, or with the pro-estrogen evidence I previously cited. In fact, I didn't realize that these authors are the very same ones who did the same study I mentioned before ("Estrogens and human scalp hair growth -- still more questions than answers" )!

By a strange coincidence, while I was at the library last night, I also picked up yet another of their studies, which I didn't even know they were going to be talking about and referencing in this one. This would be: "Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocates gender-tailored management of female versus male pattern balding", J Invest Dermatol Symp Proc 10:243-246. In that one, they found that giving estrogen to hair follicles from frontal male scalp skin showed a dose-dependent DOWNREGULATION of the very harmful TGFb-2, which is known to be a main hair growth suppressor in MPB. That study can be considered to be yet another one in support of estrogen, in addition to the other ones that I mentioned previously.

So my question to you now is this: why did you assume that this paper (the long one you cited above) is so anti-estrogen, when clearly it is not? :-) They mention the same studies I did, with the exception of the ones by Kiesewetter, and talk about the wide use of topical estrogen in Europe for MPB, citing the very same study that _I_ used when I made my big post on that subject over on HLH. They also reference the same Happle & Hoffmann study that I did, showing that estrogen is a fairly decent 5a-reductase inhibitor.

So what made you think that they were necessarily INCRIMINATING estrogen? Was it because of all that material they had about how estrogen arrests the anagen cycle of hair follicles in animals, and sends them into telogen? That was in ANIMALS! :-) As they themselves pointed out near the end, you can't just assume that the same thing happens in humans, and indeed they cited the same evidence that I did showing that estrogen actually slightly LENGTHENS anagen in human scalp hair follicles, and stimulates their growth. And I continue to be amazed that after all these years, that old Robert Smart study (another one they cited) is still causing confusion in a lot of people by making them think that the same results he got with anti-estrogens in MICE is going to have the same effect in humans. It ain't necessarily so, and the evidence we've cited demonstrates it.

So all in all, I'm pretty much in agreement with what they said. I think the preponderance of the evidence shows that estrogen is GOOD for human scalp hair, and good for fighting MPB.


Bryan is located in [NA] and he is available to meet: NO

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