Hair Loss - Homemade Follicular Neogenesis

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Homemade Follicular Neogenesis (Hair Multiplication & Research)

posted by BostonBaldy, 15.09.2007, 21:01

Hey all,

I thought I'd add some clarifications for those wanting to try this procedure. I plan on doing this soon. Several points:

1. You need both DMSO and Lithium for follicular neogenesis. DMSO positively activates the WNT/beta-catenin pathway while Lithium prevents inhibition of this pathway. Specifically, lithium prevents two components from inhibiting activation of the WNT/beta-catenin pathway: the protein glycogen synthase kinase-3beta (GSK-3b) and the gene Dickkopf-1 (DKK-1). Remarkably, recent research shows that DKK-1 is the gene most upregulated by DHT.

2. Topical caffeine does not appear to activate the WNT/beta-catenin pathway. However, caffeine does have two important functions in alopecia. First, it activates the protein sonic hedgehog (shh), which appears to play a role in hair regeneration (though more work needs to be done on this). Second, caffeine is a potent DHT blocker, so it indirectly inhibits the DKK-1 gene (which in turn inhibits the WNT/beta-catenin pathway).

3. Lithium Orotate is more bioavailable than Lithium Carbonate, so it's probably the preferred form to apply topically.

4. Several posters had concerns that new hair follicles would still be vulnerable to DHT-induced miniturization. I do not think this is the case if hairs actually grow de novo from the scalp. The work by Cotsarelis and Fuchs has shown that DHT-resistant follicular neogenesis is possible in otherwise DHT-vulnerable scalp. Regardless, even if the new hairs are DHT-vulnerable then the above procedure (if it works) will just continually replace old hairs with new hairs.

5. Finally, I should add that this procedure is VERY, VERY cheap.

Best,
BB

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