Hair Loss - about tacrolimus ?
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about tacrolimus ? (Hair Loss Research & Clinical Trials)

posted by cricket, 23.03.2008, 13:39

Maybe the role of autoimmune reaction in aga is understimate.

What about new topical drugs like tacrolimus ?
I can't find one study about an hair growth connection ,so i think
no effect ...
Could someone give info ?




» Note: Performing your original search, vellus hairs mice alopecia, in
» PubMed will retrieve 6 citations.
»
» 1: J Am Acad Dermatol. 2003 May;48(5):752-9. Links
» Transplants from balding and hairy androgenetic alopecia scalp regrow hair
» comparably well on immunodeficient mice.Krajcik RA, Vogelman JH, Malloy VL,
» Orentreich N.
» Orentreich Foundation for the Advancement of Science Inc, Cold
» Spring-on-Hudson, New York 10516, USA. ofas1@juno.com
»
» Human hair follicles were grafted onto 2 strains of immunodeficient mice
» to compare the regeneration potential of vellus (miniaturized, balding)
» and terminal (hairy, nonbalding) follicles from males and a female
» exhibiting pattern baldness. Each mouse had transplants of both types of
» follicles from a single donor for direct comparison. Grafted follicles
» from 2 male donors resulted in nonsignificant differences in mean length
» (52 mm vs 54 mm) and mean diameter (99 microm vs 93 microm) at 22 weeks
» for hairs originating from balding and hairy scalp, respectively,
» corresponding to 400% versus 62% of the mean pretransplantation diameters.
» Follicles from the female donor transplanted to several mice also resulted
» in nonsignificant differences in length (43 mm vs 37 mm) for hairs from
» balding and hairy scalp, respectively, during a period of 22 weeks. The
» mean diameter of the originally vellus hairs increased 3-fold, whereas the
» terminal hairs plateaued at approximately 50% of pretransplantation
» diameter, resulting in a final balding hair volume double that of the
» nonbalding hairs. This report shows that miniaturized hair follicles of
» pattern alopecia can quickly regenerate once removed from the human scalp
» and can grow as well as or better than terminal follicles from the same
» individual.
»
» PMID: 12734505 [PubMed - indexed for MEDLINE]
»
»
»
»
» That is <> humiliating. We move our vellus hairs to
» mice, and they can regrow.......................dammit. Dutasteride wont
» get them back though.



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