Hair Loss

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Second Study ketoconazole Cream, ie Nizoral (Hair Loss Research & Clinical Trials)

posted by HanginInThere, Hair loss University, 23.03.2008, 16:00

Title
Potentializing effect of ketoconazole on cyclosporin A-induced inhibition of keratinocyte DNA synthesis.
Author
Amsellem C; Haftek M; Thivolet J; De Doncker P; Schmitt D
Address
INSERM U 346 affiliée CNRS, Department of Dermatology, E. Herriot Hospital, Lyon, France.
Source
Acta Derm Venereol, 74: 4, 1994 Jul, 257-9
Abstract
Keratinocyte growth in vitro and DNA synthesis by epidermal cells in vivo are inhibited by therapeutic doses of cyclosporin A (CsA). This effect may be potentialized by topical treatment with ketoconazole, since this drug has been shown to inhibit CsA metabolism. Normal human skin grafts on nude mice receiving intraperitoneal injections of CsA were treated with ketoconazole cream or its placebo for 3 weeks. The keratinocyte DNA synthesis rate was evaluated through the rates of bromodeoxyuridine (BrdU) incorporation, and the trough blood levels of CsA were checked at the end of the experiment. Counting of the BrdU-labelled nuclei in human tissue sections confirmed a dose-dependent inhibition of BrdU incorporation by keratinocytes exposed to CsA. This CsA-induced inhibition was further increased in the animals treated with ketoconazole cream. This effect was best seen in the groups treated with the low-to-medium doses of CsA (12.5 and 25 mg/kg/day). However, the simultaneous increase in the circulating CsA levels was also observed in these animals. Based on our results, we speculate that the potentializing effect of ketoconazole on CsA-induced inhibition of keratinocyte DNA synthesis is systemic rather than local.
Language of Publication
English
Unique Identifier
95066569


HanginInThere is located in HAIR LOSS UNIVERSITY and he is available to meet: NO

---
Hangin..(ideal regimen) ........current regimen is just Saw Palmetto and Beta Sis

Maxi Hair by Country Life 2/day
Kal Amino Max ..Chelated Multi Mineral..2/day

DHT blockers (daily intake)
Saw Palmetto, 320mg Standardized
Pygeum 500mg
Nettles 500mg
Beta Sitosterol 125mg

Complete thread:

• Vellus hairs and Donora area hairs equal when transplanted to mice - benji, 23.03.2008, 01:09 (Hair Loss Research & Clinical Trials)
  • Vellus hairs and Donora area hairs equal when transplanted to mice - benji, 23.03.2008, 01:15
    • Vellus hairs and Donora area hairs equal when transplanted to mice - HanginInThere, 23.03.2008, 02:10
      • Vellus hairs and Donora area hairs equal when transplanted to mice - benji, 23.03.2008, 02:47
        • Vellus hairs and Donora area hairs equal when transplanted to mice - HanginInThere, 23.03.2008, 03:15
    • Vellus hairs and Donora area hairs equal when transplanted to mice - TAGOHL, 23.03.2008, 12:23
    • Vellus hairs and Donora area hairs equal when transplanted to mice - debris, 06.11.2008, 14:02
      • Vellus hairs and Donora area hairs equal when transplanted to mice - cal, 07.11.2008, 17:58
    • Vellus hairs and Donora area hairs equal when transplanted to mice - harm2, 07.03.2009, 18:12
      • Vellus hairs and Donora area hairs equal when transplanted to mice - cal, 07.03.2009, 21:12
        • Vellus hairs and Donora area hairs equal when transplanted to mice - harm2, 08.03.2009, 19:16
          • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 08.03.2009, 20:52
            • Vellus hairs and Donora area hairs equal when transplanted to mice - cal, 09.03.2009, 04:50
              • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 09.03.2009, 07:00
                • Vellus hairs and Donora area hairs equal when transplanted to mice - cal, 09.03.2009, 07:30
                  • Vellus hairs and Donora area hairs equal when transplanted to mice - Sceptic, 09.03.2009, 07:59
                    • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 09.03.2009, 08:44
              • Vellus hairs and Donora area hairs equal when transplanted to mice - harm2, 09.03.2009, 08:37
                • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 09.03.2009, 08:42
                  • Vellus hairs and Donora area hairs equal when transplanted to mice - harm2, 09.03.2009, 13:53
                    • Vellus hairs and Donora area hairs equal when transplanted to mice - damraak, 09.03.2009, 14:41
                    • Vellus hairs and Donora area hairs equal when transplanted to mice - harm2, 10.03.2009, 17:44
                      • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 10.03.2009, 20:07
      • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 07.03.2009, 22:42
  • And this is where follica is most probably going to fail - debris, 23.03.2008, 05:09
    • And this is where folica is most probably going to fail - MPB, 23.03.2008, 07:48
      • One nizoral study - benji, 23.03.2008, 10:28
        • Second and Third Nizoral Study................. - benji, 23.03.2008, 10:33
          • Fourth Nizoral study - benji, 23.03.2008, 10:41
            • Second Study ketoconazole Cream, ie Nizoral - HanginInThere, 23.03.2008, 16:00
            • Japanese study nizoral CREAM ie Ketoconazole - HanginInThere, 23.03.2008, 16:15
              • Japanese study nizoral CREAM ie Ketoconazole - mjones, 04.11.2008, 15:20
            • Study comparing Keto Cream to Keto Foam, - HanginInThere, 23.03.2008, 16:24
            • You will see a lot complaining about the Shampoo - HanginInThere, 23.03.2008, 16:32
            • What is YOUR personal testimonial - HanginInThere, 23.03.2008, 16:37
              • What is YOUR personal testimonial - benji, 23.03.2008, 22:57
                • What is YOUR personal testimonial - HanginInThere, 24.03.2008, 00:35
      • And this is where folica is most probably going to fail - benji, 23.03.2008, 10:47
    • And this is where follica is most probably going to fail - TAGOHL, 23.03.2008, 12:39
      • And this is where follica is most probably going to fail - benji, 24.03.2008, 00:04
        • And this is where follica is most probably going to fail - TAGOHL, 24.03.2008, 19:54
          • And this is where follica is most probably going to fail - benji, 24.03.2008, 23:06
            • And this is where follica is most probably going to fail - MPB, 25.03.2008, 06:16
            • And this is where follica is most probably going to fail - saturn, 05.11.2008, 15:14
              • And this is where follica is most probably going to fail - cal, 05.11.2008, 18:35
  • Vellus hairs and Donora area hairs equal when transplanted to mice - MPB, 23.03.2008, 07:40
  • about tacrolimus ? - cricket, 23.03.2008, 13:39
    • about tacrolimus ? - BRUTUS, 24.03.2008, 00:09
  • I've this idea - Amilcar, 04.11.2008, 17:30
    • I've this idea - thegreek, 04.11.2008, 19:19
      • I've this idea - HairKing, 04.11.2008, 19:35
      • I've this idea - Amilcar, 04.11.2008, 19:42
  • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 07.03.2009, 10:06
    • Vellus hairs and Donora area hairs equal when transplanted to mice - AJ, 07.03.2009, 13:03
      • Vellus hairs and Donora area hairs equal when transplanted to mice - goata007, 07.03.2009, 22:46
        • Vellus hairs and Donora area hairs equal when transplanted to mice - cal, 08.03.2009, 04:27
          • Vellus hairs and Donora area hairs equal when transplanted to mice - Steve78, 09.03.2009, 10:32
            • Vellus hairs and Donora area hairs equal when transplanted to mice - hairman2, 09.03.2009, 12:20
              • Obama to lift ban on stem cells research - ipod, 09.03.2009, 12:27
                • Obama to lift ban on stem cells research - Sceptic, 09.03.2009, 14:39
                  • Obama to lift ban on stem cells research - damraak, 09.03.2009, 14:44
                    • Obama to lift ban on stem cells research - mj2003, 09.03.2009, 16:47
                      • Obama to lift ban on stem cells research - cal, 09.03.2009, 22:29