Hair Loss - about tacrolimus ?
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about tacrolimus ? (Hair Loss Research & Clinical Trials)

posted by BRUTUS, 24.03.2008, 00:09

Has anyone heard of this stuff?

Part III.Wound Healing, Inflammation, and Fibrosis
Thymosin Beta 4 Induces Hair Growth via Stem Cell Migration and Differentiation


DEBORAH PHILPa, SHARLEEN ST-SURINa, HEE-JAE CHAa, HYE-SUNG MOONa, HYNDA K. KLEINMANa AND MICHAEL ELKINa

a Cell Biology Section, NIDCR, NIH, Bethesda, Maryland, USA

Key Words: cell migration • hair follicle growth • angiogenesis • wound healing • stem cells • cell survival • inflammation • gene expression • laminin-5 • proteases • zyxin • endothelial cells • thymosin beta 4 • keratinocytes • MMPs • TIMPs

Address for correspondence: Hynda K. Kleinman, Ph.D., Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892. Voice: 301-496-4069; fax: 301-402-0897. hkleinman@dir.nidcr.nih.gov

Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.


Part III.Wound Healing, Inflammation, and Fibrosis
Thymosin Beta 4 Induces Hair Growth via Stem Cell Migration and Differentiation


DEBORAH PHILPa, SHARLEEN ST-SURINa, HEE-JAE CHAa, HYE-SUNG MOONa, HYNDA K. KLEINMANa AND MICHAEL ELKINa

a Cell Biology Section, NIDCR, NIH, Bethesda, Maryland, USA

Key Words: cell migration • hair follicle growth • angiogenesis • wound healing • stem cells • cell survival • inflammation • gene expression • laminin-5 • proteases • zyxin • endothelial cells • thymosin beta 4 • keratinocytes • MMPs • TIMPs

Address for correspondence: Hynda K. Kleinman, Ph.D., Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892. Voice: 301-496-4069; fax: 301-402-0897. hkleinman@dir.nidcr.nih.gov

Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.


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