Hair Loss - My "theory" of baldness.....................

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My "theory" of baldness..................... (Topicals)

posted by benji, 08.04.2008, 20:33

For any of you who may be newbies wondering about baldness-------------you inherit a variant of the androgen receptor gene that can express itself more or less strongly depending on genetic chance. If it expresses itself strongly with CAG-repeates, the hair outside your wreaths androgen receptor's are much more adept at uptaking male hormone, especially dihydrotestosterone. Having alot of DHT in the scalp tissue (bald men have been shown to have more DHT in their scalps, but not in the blood, indicating that the alpha five reductase enzymes in the root sheaths of each and ever hair follicle on your head are probably more active than a guy with all his hair) has been shown to be able to invigorate androgen receptors even MORE. One too much androgen is uptaken..............eventually something happens to the hair follicle and a different set of genetic instructions are obeyed within it. The dermal papilla starts cranking out way too much DKK_1, which leads to the cell death of the keratincoyetes in the root sheath........................these dead cells in turn hanging around the infidulum is probably why the immune system begins attacking the hair follicle and TGF beta and excessive collagenous deposition is downstream from it. That is probably "baldness", as the immune system is going to try to eliminate dead cells and anything around the area is going to be effected by all the infllammatory subtstances the immune system will use. Baldness looks like organ rejection microscopically. Its been shown that wreath area hairs can succumb to testosterone and DHT if experiments give enough of them to the hairs.......................so I dont believe their is some magic difference in the hair's basic characteristics but a difference in the amount of DHT the hair can make via its alpha five reductase enzyme in their root sheaths and a big difference in how well the hairs androgen receptors work and how chemcially stable they are. In a way male baldness is probably because you have too-well-working-androgen-receptors and too-well-working-alpha-five-reductase-enzymes in your hair. You are "too manly" in a place you dont want to be.



Obviously, "my theory" places the blame at DKK-1's doorstep, but its all because of too-well working androgen receptors and too well working alpha five reductase enzymes. I honestly think if you could get Brad Pitts hair to uptake the amount of androgen our follicles uptake...............he'd be going bald too, by the same mechanisms we are for the most part dependent on the intesitity of his immune systems response. Its known that the variant of the androgen receptor gene is located on the x-chromosome and comes from your mother, but the other genes in baldness are autologous (or are thought to be) and aren't parent specific. Too many androgens duing fetal development may play a role. We will know if someone ever does a study on digit ratios and baldness in a large population. Im guessing at least a small correlation will be found myself.


benji is located in [NA] and he is available to meet: NO

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