Hair Loss - My "theory" of baldness.....................

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My "theory" of baldness..................... (Topicals)

posted by Goingallout, 09.04.2008, 00:20

» For any of you who may be newbies wondering about baldness-------------you
» inherit a variant of the androgen receptor gene that can express itself
» more or less strongly depending on genetic chance. If it expresses itself
» strongly with CAG-repeates, the hair outside your wreaths androgen
» receptor's are much more adept at uptaking male hormone, especially
» dihydrotestosterone. Having alot of DHT in the scalp tissue (bald men have
» been shown to have more DHT in their scalps, but not in the blood,
» indicating that the alpha five reductase enzymes in the root sheaths of
» each and ever hair follicle on your head are probably more active than a
» guy with all his hair) has been shown to be able to invigorate androgen
» receptors even MORE. One too much androgen is
» uptaken..............eventually something happens to the hair follicle and
» a different set of genetic instructions are obeyed within it. The dermal
» papilla starts cranking out way too much DKK_1, which leads to the cell
» death of the keratincoyetes in the root
» sheath........................these dead cells in turn hanging around the
» infidulum is probably why the immune system begins attacking the hair
» follicle and TGF beta and excessive collagenous deposition is downstream
» from it. That is probably "baldness", as the immune system is going to try
» to eliminate dead cells and anything around the area is going to be
» effected by all the infllammatory subtstances the immune system will use.
» Baldness looks like organ rejection microscopically. Its been shown that
» wreath area hairs can succumb to testosterone and DHT if experiments give
» enough of them to the hairs.......................so I dont believe their
» is some magic difference in the hair's basic characteristics but a
» difference in the amount of DHT the hair can make via its alpha five
» reductase enzyme in their root sheaths and a big difference in how well
» the hairs androgen receptors work and how chemcially stable they are. In a
» way male baldness is probably because you have
» too-well-working-androgen-receptors and
» too-well-working-alpha-five-reductase-enzymes in your hair. You are "too
» manly" in a place you dont want to be.
»
»
»
» Obviously, "my theory" places the blame at DKK-1's doorstep, but its all
» because of too-well working androgen receptors and too well working alpha
» five reductase enzymes. I honestly think if you could get Brad Pitts hair
» to uptake the amount of androgen our follicles uptake...............he'd
» be going bald too, by the same mechanisms we are for the most part
» dependent on the intesitity of his immune systems response. Its known that
» the variant of the androgen receptor gene is located on the x-chromosome
» and comes from your mother, but the other genes in baldness are autologous
» (or are thought to be) and aren't parent specific. Too many androgens duing
» fetal development may play a role. We will know if someone ever does a
» study on digit ratios and baldness in a large population. Im guessing at
» least a small correlation will be found myself.

You lost me with some of this -- I don't know what DKK is for instance -- but it overall makes a lot of sense. The itchiness I get in my scalp is IMO and I have thought independently exactly what you said, essentially an autoimmune response to cell death, akin to organ rejection I guess you could say. My itchy scalp that correlates with my hair loss feels a lot like the itch from a wound that is healing -- as the immune system clears out dead tissue after the scab has formed. Too bad there's not a really cheap topical that inhibits DHT only locally and doesn't smell and doesn't cause itching, etc.


Goingallout is located in [NA] and he is available to meet: NO

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