Hair Loss - My "theory" of baldness.....................

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My "theory" of baldness..................... (Topicals)

posted by benji, 09.04.2008, 00:46

DKK-1 is a substance in the body that was not known until fairly recently to be involved in the dermal papilla of hair follicles. The antigens (negative growth factors) released by the dermal papilla as currently known are Thrombospondin, TGF-beta 1 and 2, PKC, TNF-alpha, and FGF-5.


DKK1 is a newly discovered one. It directly leads to not only a supression of keratinocyte cell division, but keratinocyte apoptosis (cell death). This would put dead cells in the body (around the infidulum where mysteriously the first inflammation is seen in androgenic alopecia).


DKK-1 has also been shown to, in FOLLICA experiments, to keep new hair follicles from forming AT ALL if it keeps getting applied to mice after wounding.


Here is the DKK-1 info via PubMed:


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1: J Invest Dermatol. 2008 Feb;128(2):262-9. Epub 2007 Jul 26. Links
Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes.Kwack MH, Sung YK, Chung EJ, Im SU, Ahn JS, Kim MK, Kim JC.
Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea.

Recent studies suggest that androgen-driven alteration to the autocrine and paracrine factors produced by scalp dermal papilla (DP) cells may be a key to androgen-potentiated balding. Here, we screened dihydrotestosterone (DHT)-regulated genes in balding DP cells and found that dickkopf 1 (DKK-1) is one of the most upregulated genes. DKK-1 messenger RNA is upregulated in 3-6 hours after 50-100 nM DHT treatment and ELISA showed that DKK-1 is secreted from DP cells in response to DHT. A co-culture system using outer root sheath (ORS) keratinocytes and DP cells showed that DHT inhibits the growth of ORS cells, and neutralizing antibody against DKK-1 significantly reversed the growth inhibition of ORS cells. Analysis of co-cultured ORS cells showed a significant increment of sub-G1 apoptotic cells in response to DHT. Also, recombinant human DKK-1 inhibited the growth of ORS cells and triggered apoptotic cell death. In addition, DHT-induced epithelial cell death in cultured hair follicles was reversed by neutralizing DKK-1 antibody. Moreover, immunoblotting showed that the DKK-1 level is up in the bald scalp compared with the haired scalp of patients with androgenetic alopecia. Altogether, our data strongly suggest that DHT-inducible DKK-1 is involved in DHT-driven balding.

PMID: 17657240 [PubMed - indexed for MEDLINE]


benji is located in [NA] and he is available to meet: NO

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