Hair Loss - TAGOHL, .....Ectodysplasin and "skin, hair, nails, teeth, sweat glands"

classified ads


shop
Forum News Hair Transplant Hair Replacement Topical All Natural Drugs Hair Multiplication Gallery Female Hair Loss

Hair Loss

Forum Index   Personal Journal   Poll

Log in | User | Register

Search:  
Back to forum
Board view

FREE Hair Transplant Consultations with HDC: London - Sep 1-5
 click here
 

TAGOHL, .....Ectodysplasin and "skin, hair, nails, teeth, sweat glands" (Topicals)

posted by benji, 09.04.2008, 20:34

http://ghr.nlm.nih.gov/gene=eda

(maybe this gene set being active in a particular way along with a particular variant of the AR-gene are what is necessary for MPB-to be inherited. I wonder if they can "block" what is necessary in pregnant mothers someday----not that this will help us)

Reviewed August 2006
What is the official name of the EDA gene?
The official name of this gene is “ectodysplasin A.”

EDA is the gene's official symbol. The EDA gene is also known by other names, listed below.

What is the normal function of the EDA gene?
The EDA gene provides instructions for making a protein called ectodysplasin A. This protein is part of a signaling pathway that plays an important role in development before birth. Specifically, it is critical for interactions between two embryonic cell layers called the ectoderm and the mesoderm. In the early embryo, these cell layers form the basis for many of the body's organs and tissues. Ectoderm-mesoderm interactions are essential for the formation of several structures that arise from the ectoderm, including the skin, hair, nails, teeth, and sweat glands.

The EDA gene provides instructions for producing many slightly different versions of ectodysplasin A. One version, ectodysplasin A1, interacts with a protein called the ectodysplasin A receptor (produced from the EDAR gene). On the cell surface, ectodysplasin A1 attaches to this receptor like a key in a lock. When these two proteins are connected, they trigger a series of chemical signals that affect cell activities such as division, growth, and maturation. Before birth, this signaling pathway controls the formation of ectodermal structures such as hair follicles, sweat glands, and teeth.

How are changes in the EDA gene related to health conditions?
hypohidrotic ectodermal dysplasia - caused by mutations in the EDA gene
More than 80 different mutations in the EDA gene have been identified in people with hypohidrotic ectodermal dysplasia. These mutations cause the X-linked form of the disorder, which accounts for 95 percent of all cases of hypohidrotic ectodermal dysplasia. (X-linked disorders are caused by mutations in genes on the X chromosome, one of the two sex chromosomes.)

Some mutations in the EDA gene change single DNA building blocks (base pairs), whereas other mutations insert or delete genetic material in the gene. These changes lead to the production of a nonfunctional version of the ectodysplasin A protein. This abnormal protein cannot trigger chemical signals needed for normal interactions between the ectoderm and the mesoderm. Without these signals, hair follicles, teeth, sweat glands, and other ectodermal structures do not form properly, leading to the characteristic features of hypohidrotic ectodermal dysplasia.

Where is the EDA gene located?
Cytogenetic Location: Xq12-q13.1

Molecular Location on the X chromosome: base pairs 68,752,635 to 69,176,046


benji is located in [NA] and he is available to meet: NO

Post reply
 

Complete thread:

Back to forum
Board view
36245 Postings in 3349 Threads, 1558 registered users
Hair Loss | Admin contact
powered by MLF | FORUM POLICY

Dr. Klein's REMOX Topical Hair Loss Therapy
 click here