Hair Loss - Let's focus on the FUNDAMENTALS, not the little details

classified ads


shop
Forum News Hair Transplant Hair Replacement Topical All Natural Drugs Hair Multiplication Gallery Female Hair Loss

Hair Loss

Forum Index   Personal Journal   Poll

Log in | User | Register

Search:  
Back to forum
Board view

FREE Hair Transplant Consultations with HDC: London - Sep 1-5
 click here
 

Let's focus on the FUNDAMENTALS, not the little details (Topicals)

posted by Bryan, 09.04.2008, 21:41
(edited by Bryan on 09.04.2008, 21:52)

» Bryan,
» The thing is man...................is that androgens stimulate body
» hair in men and women and everyone. In looking at DKK-1, I suppose I am
» (again) looking for a piece of the puzzle in which we can "stick our
» finger" in the MPB process and stop it.
But there's no real lack of different ways we can potentially stick our finger in the MPB processs and stop it. For a long time on hairloss sites there's been this utter fascination with the veritable "alphabet soup" of substances of all kinds that show a difference in production levels between balding and non-balding hair follicles. Just look at all the times that TGF-beta-1 and TGF-beta-2 and IGF-1 and VEGF have been mentioned and discussed on these sites, and thought to be the final key to the mystery of balding! DKK-1 is just the latest addition to this list, and the "alphabet soup" is getting really robust and full-flavored! :-D

Again, I feel this fascination with all the various factors that are different between balding and non-balding hair follicles is ok, but we're really just treading water here. It's all mainly just a smoke screen until we find out the fundamental REASON for the difference in production levels of that "alphabet soup" of substances which are different between balding and non-balding hair follicles. And who knows?? We may even stumble upon reasonably effective treatments for balding here and there by searching for TGF-beta inhibitors, DKK-1 inhibitors, etc. But in my humble opinion, it's still basically just a waiting game until we can find out the fundamental REASON for those differences.

» Bryan, on another note......................as far as "2 different types
» of hair on the head"..............I just dont believe that. I reposted
» that study showing high testosterone added to occipital scalp hairs caused
» apoptosis and I seen another study (dont know if I put it up anywhere) that
» showed the androgen receptors in MPB-area sebacous glands were much better
» at binding male hormone than androgen-receptors from non-MPB
» areas.........leading obviously to the conclusion that more-active
» androgen receptors or more chemically stable ones in MPB-areas are the
» reason for the "difference" in the hairs. Ive suggested over and over that
» if we could transfect someone without MPB hairs in an ex vivo experiment
» with the whole hair cultured with extra androgen receptors and give them a
» dose of androgens like a guy with MPB probably sees his follicles uptake,
» I'd bet they'd respond negatively. I simply think Brad Pitt's hair isn't
» seeing as much androgens as ours is via less DHT in the area, and androgen
» receptors that dont function "as well" as ours do.

I don't have any doubt about that, either. But I personally have relatively little concern for all the various factors which get discussed ad nauseum on hairloss sites which have to do with different levels of androgenic stimulation, and the resulting different severities of balding from one person to another. To me, that's a relatively trivial and obvious matter. What interests me far more is what accounts for the FUNDAMENTAL DIFFERENCE between body hair follicles and scalp hair follicles which makes them respond to androgens in an OPPOSITE fashion. Until we can figure that out, we're mainly just spinning our wheels.

.


Bryan is located in [NA] and he is available to meet: NO

Post reply
 

Complete thread:

Back to forum
Board view
36226 Postings in 3348 Threads, 1557 registered users
Hair Loss | Admin contact
powered by MLF | FORUM POLICY

Dr. Klein's REMOX Topical Hair Loss Therapy
 click here