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TAGOHL, ..... (Follica and new genetic information) (Topicals)

posted by benji, 10.04.2008, 21:27

» Benji, thanks for the info -- very interesting. I need to ponder all this
» stuff. Here's a couple more abstracts. The first one is another recent
» genetic study which shows that a polymorphism in the ectodysplasin-A
» receptor gene is what gives Asians thick hair. The second study shows that
» ectodysplasin helps control the switch from anagen to catagen (early
» termination of anagen -- short growth cycles -- are a feature of MPB).
» Gene therapy for baldness would be really, really nice if it happens
» someday.
»
» Hum Mol Genet. 2008 Mar 15;17(6):835-43.
»
» A scan for genetic determinants of human hair morphology: EDAR is
» associated with Asian hair thickness.
»
» Department of Human Genetics, Graduate School of Medicine, The University
» of Tokyo, Hongo, Tokyo, Japan.
»
» Hair morphology is one of the most differentiated traits among human
» populations. However, genetic backgrounds of hair morphological
» differences among populations have not been clarified yet. In addition,
» little is known about the evolutionary forces that have acted on hair
» morphology. To identify hair morphology-determining genes, the levels of
» local genetic differentiation in 170 genes that are related to hair
» morphogenesis were evaluated by using data from the International HapMap
» project. Among highly differentiated genes, ectodysplasin A receptor
» (EDAR) harboring an Asian-specific non-synonymous single nucleotide
» polymorphism (1540T/C, 370Val/Ala) was identified as a strong candidate.
» Association studies between genotypes and hair morphology revealed that
» the Asian-specific 1540C allele is associated with increase in hair
» thickness. Reporter gene assays suggested that 1540T/C affects the
» activity of the downstream transcription factor NF-kappaB. It was inferred
» from geographic distribution of 1540T/C and the long-range haplotype test
» that 1540C arose after the divergence of Asians from Europeans and its
» frequency has rapidly increased in East Asian populations. These findings
» lead us to conclude that EDAR is a major genetic determinant of Asian hair
» thickness and the 1540C allele spread through Asian populations due to
» recent positive selection.
»
» PMID: 18065779 [PubMed - in process]
»
» Involvement of the Edar signaling in the control of hair follicle
» involution (catagen).
»
» Department of Dermatology, Boston University School of Medicine, 609
» Albany St., Boston, MA 02118, USA.
»
» Ectodysplasin (Eda) and its receptor (Edar) are required for normal
» development of several ectodermal derivatives including hair follicles
» (HFs). Here, we show that during the murine hair cycle the expression of
» Eda A1, Edar, Edaradd, and TRAF6 transcripts are minimal in the resting
» phase and maximal during HF transition from active growth to regression
» (catagen). Eda A1 mRNA and Edar proteins were expressed in the hair matrix
» and outer and inner root sheaths of anagen HFs. During catagen, Eda A1 mRNA
» and Edar protein were expressed in the outer and inner root sheaths and
» later in the secondary hair germ. Catagen development accompanied by
» increased apoptosis in the outer root sheath was significantly accelerated
» in downless mice or after treatment of wild-type mice by a fusion protein
» that inhibits Edar signaling, compared with the corresponding controls.
» Microarray, real-time polymerase chain reaction, and immunohistochemical
» analyses of skin of downless mice revealed a strong decrease of expression
» of X-linked inhibitor of apoptosis protein (XIAP), compared with the
» controls, suggesting XIAP as a target for Edar signaling. Thus, our data
» demonstrate that in addition to its well-established role in HF
» morphogenesis, Edar signaling is also involved in hair cycle control and
» regulates apoptosis in HF keratinocytes during catagen.
»
» PMID: 17148670 [PubMed - indexed for MEDLINE]



This is profoundly interesting information. Its the type of literal proof I'd always thought they'd be finding "someday" about how genetics directly controls hair thickness, hairlines, shapes of wreaths, etc. I noticed that the Edar signalling was implicated "involved in hair cycle control and
» regulates apoptosis in HF keratinocytes during catagen". Its the keratinocyte cell death that is intriguing to me for the reason that I think it just might be dead keratinocyte cells in the infidula downstream of DKK1, that might get the immune system interested in the follicle. If men with baldness lack XIAP, the "X-linked inhibitor of apoptosis protien" or have much less of it genetically, perhaps its why DKK-1 is so detrimental to our follicles over other men.

What is intriguing to me personally is this................what could Follica do if a way to upregulate the "Asian-specific non-synonymous single nucleotide
» polymorphism (1540T/C, 370Val/Ala)" or include it in their topical or internal after the skin-re-epilithialization period in their process someday, and "give" the new hair made great hair genetics no matter where its made.

Ive went on and on (Im sure youve seen it) about my "inkling" that Follica might be able to make very good hair back in the donor area of men post-FUE..............but might make hair that is just like MPB hair or might make thinner weaker hairs in MPB scalp due to all the genes that might be at play in the frontal scalp vs. donor scalp. Its a "defeatist"-kinda thought, but all the razzmatazz of promising treatments over the years have left me looking for ways things might fail vs. how they might succeed. ICX, for example (and Aderans), now honestly appear to be at least five years away in the best-case scenario to me now----if indeed within the next 10.

I'll never forget a doctor going over baldness with me when I was 25, and how he said "let me show you something" and he ran his finger up the side of my head and told me you can "feel" where you wreath is going to start genetically because the hair will start feeling different (weaker) at a certain point. It did. This was before I got on finasteride. Now the "change" in feeling is much more subtle, but it was pretty obvious then. Ive seen Washenik discuss how the skin grows up over the top of the scalp in fetal development and how one's pattern seems to be determined during this time. It all seems so profoundly genetically hard-wired to me. Its amazing how genes work. I knew a family once that had a Iraqi father and a blonde European mother. Their four kids all looked differnt. One looked very Arab (and was slim), one looked like a farm boy from the midwest with medium brown hair (hefty), one of the girls looked like an middle eastern model (dark skin, dark hair and beautiful), and the other daughter was a very plain (some would say kinda homely) blonde gal with light skin (and blue eyes) that was prone to heaviness. It seemed to me that genetics was like a deck of cards and your chances of inheriting this or that came from those cards getting really mixed up and you drawing this one or that one. Two of those kids looked "very white" and the other to looked very Arabain. It was not a mix of the two as I'd expected. The blonde was very blonde---and the two that had black hair had JET-BLACK hair. Mystifying that such totality was "selected" and the two phenotypes didnt "mix" somewhat to produce brown hair like the hefty brother had.


benji is located in [NA] and he is available to meet: NO

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