Hair Loss

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DHT 101 (Propecia, Avodart, Spiro, DHT & hormones ...)

posted by cal, 13.04.2008, 05:11

Shrinking and killing a hair follicle with MPB takes three things:

1. That follicle's native home area of your scalp must be genetically susceptible to androgen damage. (Transplanted follicles will retain the genetic programming of their orignal location no matter where you put them.)

2. Androgens hitting the follicle. Type#2 DHT is far and away the biggest culprit, although all androgens are probably hurtful to some extent. Some of the androgens are coming just from circulating blood, but a lot of the androgen damage is coming from DHT manufactured right there in the follicle itself.

3. Time. MPB damage seems to start accumulating literally at puberty, but it takes decades for the slow accumulation of damage to become clearly visible for most of us. (But a small percentage of guys is unlucky enough to be looking thin on top before they're even out of high school.)





Age-related thinning also happens even in the "safe zone" hairs for a lot of men. Particularly those men who have already gotten extensive early MPB in the unsafe areas.

I personally subscribe to the theory that there is probably no such thing as a 100% androgen-proof hair follicle. I suspec that it's really all just a matter of degree. Hairs that still look good into your retirement years (and also the men who never seem to get any MPB at all) are probably still getting some small amount of androgen damage. The genetic susceptibility is probably just low enough that the man will die of old age before the loss in those hairs becomes visible.

Complete thread:

• DHT 101 - boris342002, 02.04.2008, 17:50 (Propecia, Avodart, Spiro, DHT & hormones ...)
  • DHT 101 - hischko, 03.04.2008, 15:49
  • DHT 101 - Bryan, 03.04.2008, 17:15
    • DHT 101 - cal, 13.04.2008, 05:11