Hair Loss - Let's focus on the FUNDAMENTALS, not the little details

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Let's focus on the FUNDAMENTALS, not the little details (Topicals)

posted by haroldo, 15.04.2008, 01:45

» » Bryan,
» » The thing is man...................is that androgens stimulate body
» » hair in men and women and everyone. In looking at DKK-1, I suppose I am
» » (again) looking for a piece of the puzzle in which we can "stick our
» » finger" in the MPB process and stop it.
»
» But there's no real lack of different ways we can potentially stick our
» finger in the MPB processs and stop it. For a long time on hairloss sites
» there's been this utter fascination with the veritable "alphabet soup" of
» substances of all kinds that show a difference in production levels between
» balding and non-balding hair follicles. Just look at all the times that
» TGF-beta-1 and TGF-beta-2 and IGF-1 and VEGF have been mentioned and
» discussed on these sites, and thought to be the final key to the
» mystery of balding! DKK-1 is just the latest addition to this list, and
» the "alphabet soup" is getting really robust and full-flavored! :-D
»
» Again, I feel this fascination with all the various factors that are
» different between balding and non-balding hair follicles is ok, but we're
» really just treading water here. It's all mainly just a smoke screen until
» we find out the fundamental REASON for the difference in production levels
» of that "alphabet soup" of substances which are different between balding
» and non-balding hair follicles. And who knows?? We may even stumble upon
» reasonably effective treatments for balding here and there by searching for
» TGF-beta inhibitors, DKK-1 inhibitors, etc. But in my humble opinion, it's
» still basically just a waiting game until we can find out the fundamental
» REASON for those differences.
»
» » Bryan, on another note......................as far as "2 different
» types
» » of hair on the head"..............I just dont believe that. I reposted
» » that study showing high testosterone added to occipital scalp hairs
» caused
» » apoptosis and I seen another study (dont know if I put it up anywhere)
» that
» » showed the androgen receptors in MPB-area sebacous glands were much
» better
» » at binding male hormone than androgen-receptors from non-MPB
» » areas.........leading obviously to the conclusion that more-active
» » androgen receptors or more chemically stable ones in MPB-areas are the
» » reason for the "difference" in the hairs. Ive suggested over and over
» that
» » if we could transfect someone without MPB hairs in an ex vivo
» experiment
» » with the whole hair cultured with extra androgen receptors and give them
» a
» » dose of androgens like a guy with MPB probably sees his follicles
» uptake,
» » I'd bet they'd respond negatively. I simply think Brad Pitt's hair
» isn't
» » seeing as much androgens as ours is via less DHT in the area, and
» androgen
» » receptors that dont function "as well" as ours do.
»
» I don't have any doubt about that, either. But I personally have
» relatively little concern for all the various factors which get discussed
» ad nauseum on hairloss sites which have to do with different levels
» of androgenic stimulation, and the resulting different severities of
» balding from one person to another. To me, that's a relatively trivial and
» obvious matter. What interests me far more is what accounts for the
» FUNDAMENTAL DIFFERENCE between body hair follicles and scalp hair follicles
» which makes them respond to androgens in an OPPOSITE fashion. Until we can
» figure that out, we're mainly just spinning our wheels.

OK just wrote and lost a large reply but basically - those various factors you are talking about are in themselves the fundamental difference that you are looking for. One may prove to be upstream of the others or more important but there is no reason for scalp hairs to behave differently to body hairs beyond the fact that they are different cell types and thus express different genes just as skin cells and muscle cells do. On the other hand all may be equally important or some may only play a part in balding white men, others in Asian men etc. But at the end of the day theres no reason behind it other than the reality of which genes get transcribed when the androgen binds to the androgen receptor and travels into the nucleus.
hh


haroldo is located in [NA] and he is available to meet: NO

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