Hair Loss - Let's focus on the FUNDAMENTALS, not the little details

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Let's focus on the FUNDAMENTALS, not the little details (Topicals)

posted by haroldo, 16.04.2008, 14:42

» » » I'm not entirely sure what your overall point is. I don't
» » » really disagree with anything you said.
» »
» » I guess from your earlier post it seemed like you felt the study of and
» » worrying about stuff like TGF-Beta etc was not important because there
» was
» » a fundamental difference that would explain WHY scalp hairs produced
» growth
» » inhibitors when exposed to DHT and why beard hairs produced growth
» » promoters.
»
» I think the study of and worrying about stuff like TGF-beta IS important
» (at least for the time being), because it's things like that that are the
» only ways we currently have of fighting MPB. These "downstream" methods
» like TGF-beta inhibitors, antiandrogens, etc., are still relatively crude,
» but we don't yet have anything more "upstream".
Well I would tend to think of antiandrogens as acting upstream relative to something like a TGF-Beta inhibitor which is more downstream in that it is expressed in response to androgens.

»
» And there IS a fundamental difference that will explain why scalp hairs
» and body hairs respond in opposite fashion to androgens. We just don't
» know what it is yet.
»
» » Whereas I was trying to say that there is no reason behind
» » the difference - it just is.
»
» HUH?? What do you mean, "there is no reason"? Do you think they respond
» in opposite fashion to androgens just because God (or the Devil) tells them
» to?? :-P

No. They respond in opposite fashions because they express proteins that have opposite effect on keratinocytes. Thats it. There is no deeper reason than that and we already know this and no many of the proteins in question. Thats what I am saying in terms of there is no reason beyond the genetic reality

» » Maybe I misunderstood you in that you were saying
» » that it is a waste of our time now to worry about it when we still dont
» » know exactly how much of a role each of these new factors plays in the
» » balding process and what needs to be done to stop them but it sounded
» » like you wanted to know why they were produced at all.
»
» Oh, I guarantee you that I most definitely _do_ want to know why scalp
» hair follicles and body hair follicles produce growth suppressors and
» growth promoters (respectively). Understanding that difference would
» obviously be required for us to attack the problem at the most UPSTREAM
» point in the process, which almost certainly would be more desirable.
Well I think androgens are the most upstream part of the pathway. And that is a step that is, at least for many people, somewhat undesirable to attack. A local intervention on something downstream of that seems preferrable to my mind.

» » At any rate I do think that whole alphabet soup stuff is really
» important
» » and exciting and that is where any breakthrough in understanding and
» » treatment effectiveness is going to come from in this whole thing.
»
» It's a relative thing. Finding out more and more about each member
» of the alphabet soup that's involved in balding SEEMS important, but that's
» only because we don't understand the initial steps in the process. We need
» to know the FUNDAMENTAL REASON(S) why scalp follicles and body follicles
» respond in opposite ways to androgens before we can really get to the heart
» of the matter with the most direct treatments, as opposed to the
» indirect treatments that we have today, and probably the forseeable
» future.
OK. Its the whole fundamental reasons thing that I dont understand/dont think exists. androgen + receptor -> production of hair promoters/inhibitors.Thats it really. Trying to understand why beyond that is like wanting to understand the fundamental reason why someone has blonde hair rather than black beyond understanding that they have genes that encode for different hair pigments. IMO the why was explained a few years ago in that first study on beard vs balding scalp dermal papillae.


haroldo is located in [NA] and he is available to meet: NO

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