Hair Loss - Let's focus on the FUNDAMENTALS, not the little details

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Let's focus on the FUNDAMENTALS, not the little details (Topicals)

posted by haroldo, 17.04.2008, 05:37

» » Well I would tend to think of antiandrogens as acting upstream relative
» to
» » something like a TGF-Beta inhibitor which is more downstream in that it
» is
» » expressed in response to androgens.
»
» Sure, it's more upstream than a TGF-beta inhibitor would be, but I want to
» go ALL the way upstream where that first little creek starts to form! ;-)

I think I know what you mean by upstream now. Its not what people mean when they talk about upstream or downstream in terms of signal transduction but I think you are talking about the developmental stage as in "why does a skin cell become a skin cell? why does a hair cell become a hair cell? why does a scalp hair become a scalp hair etc" If thats so then....I dont really think that stuff is going to be of much use to us. They might be useful for engineering people without hairloss or hair multiplication but otherwise i dont see how it helps so much as the horse as already bolted so to speak.

» » » HUH?? What do you mean, "there is no reason"? Do you think they
» » » respond in opposite fashion to androgens just because God (or the
» » » Devil) tells then to?? :-P
» »
» » No. They respond in opposite fashions because they express proteins
» » that have opposite effect on keratinocytes. Thats it.
»
» Ok. Now tell me WHY they do that! :-)

They do that for the same reason that skin cells transcribe whatever proteins they do in response to androgens just as cells of the prostate do. Because those are the genes that will be expressed in response to androgens in those cell types.

» » There is no deeper reason than that and
» » we already know this and no many of the proteins in question.
» » Thats what I am saying in terms of there is no reason beyond
» » the genetic reality
»
» You've gotta do a LOT better than that. No burying your head in the sand
» and saying that it happens because it happens! :confused:

Well....it does. But I now see more what you are getting at with I think. That you are interested in why some hairs express growth factors etc. But with the evidence that androgens can destroy even occipital hairs in high enough concentration I think theres a fair chance that all scalp hairs are set up in such a way and that the differences in balding between different areas of the scalp and different people could pretty much be explained in terms of androgen receptor expression/sensitivity and local androgen levels as is already the case. At any rate since dermal papillae wherein the bad response originates are not replaced fromm cycle to cycle I dont think there is that much that could be done to fundamentally change a "bad one" to a "good one" them even if there are such things.

» » Well I think androgens are the most upstream part of the pathway.
»
» Nope, that's not the most upstream part. The most upstream part is the
» reason for the paradoxical nature of the response to androgens.
»
» » OK. Its the whole fundamental reasons thing that I dont understand/dont
» » think exists. androgen + receptor -> production of hair
» » promoters/inhibitors.Thats it really.
»
» Harold, come on, man. Pull your head out of the sand.
I think I understand what you are saying now. At the same time, unless you are planning to replace most of your existing follicles with new ones a la Follica then I think you have to look at all that alphabet soup stuff. Cos once that follicle has developed in such a way that it is going to produce those genes in response to androgen you either have to keep it away from androgens, interfere with the resulting production of those genes or introduce a growth factor or other third party that is powerful enough to overcome those negative signals.
hh


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