Hair Loss - Let's focus on the FUNDAMENTALS, not the little details

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Let's focus on the FUNDAMENTALS, not the little details (Topicals)

posted by haroldo, 21.04.2008, 02:19

» » I think I hate this forum. Thats the 2nd long reply I have lost in a
» couple
» » of days. This one seemed to go through. Anyway...
»
» David thought he had a fix for the problem, but I just emailed him a while
» ago to let him know that it's still not working...
Cool.

» » Well technically the androgen is the most upstream signal in this
» process.
» » There is nothing upstream of that as the term upstream and downstream
» is
» » used in terms of signal transduction. But now I know that you meant a
» » developmental stage that occured before the hair follicle cells had
» » committed to becoming hair follicle cells.
»
» I'm using that term more generally than just in the context of "signal
» transduction". I'm using it to describe a whole sequence of events,
» starting with the initial reason(s) for why hair follicles first become
» either suppressed, stimulated, or stay neutral to androgens.
OK. A tricky area but yeah this is a problem/question the Follica guys are going to run into and examine before too long so I think the chances are good that we might have the beginnings of an answer and possibly an idea of how it might be controlled within a couple of years. Which is pretty good.

» » OK. But what causes one type to become one or the other has already
» been
» » and gone by the time we are here to worry about it. Causing one hair
» » follicle to change into another type of hair follicle once they have
» » diffferentiated is like getting a skin cell to change into a muscle
» cell.
» » Possible in the test tube perhaps but very tricky at the least in vivo.
»
» I'm not so sure about all that. Time will tell.
True.

» » OK. I suspect the answer wont be particularly profound though.
»
» Hey, I'm counting on that!
»
» I suspect that the simpler the explanation is, the more likely it is that
» we'll be able to formulate the Ultimate Treatment for MPB! :-)

Indeed. It would be nice if the Gods of Hairlosss Research smiled upon us true believers for once :)
As I mentioned one of the biggest questions around the Follica technique will be are the new hair follicles as DHT sensitive as the previous follicles in the area. If they are then I suspect they will at least begin trying to figure out why they are and if that can be changed (they seemed to figure out the pigmented/unpigmented hair thing pretty quickly). If not they may not worry about it too much. So the good news is that people should be looking into this very question. Fingers crossed.
hh


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