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Why would anyone use oral dutasteride instead of topical? (Propecia, Spiro, DHT & hormones ...)

posted by Goingallout, 28.04.2008, 16:07

I have a question: why anyone would take dutasteride orally vs. applying it topically?

I would think Glaxo would figure out a way to make a topical out of this rather than turning it into a pill.

At =>0.5mg daily dosages, taken orally the drug reduces serum DHT levels by 90% but scalp DHT levels only by about + - 50%.

I just switched from taking it orally (0.5mg daily) to taking it by rubbing it on my head in a base of pure aloe vera gel. The book Double A recommends doing this for 3 minutes (have not read it but have read about it), but for now I am leaving it on for significantly more time.

What I have noticed is that all the side effects I notice of dutasteride are still there, but my low-grade scalp itch (which already has been greatly reduced by oral administration) is completely gone. This leads me to think that near-full DHT suppression is happening in the scalp. The fact that I am leaving the topical on for an hour or more means that I am probably just getting the same systemic or blood stream suppression as before while dramatically increasing scalp suppression.

After I have spent a week or so applying the topical and leaving it for a long time, I will switch to the 3-minute application called for by the book Double-A. I believe that I'll minimize sexual side effects while achieving maximum benefit.

Here's my thinking: by both methods, it absorbs into the body and enters into the bloodstream. But I believe that if it absorbs into the body through the scalp, it must suppress a higher percentage of scalp DHT than does the oral administration. I would in fact believe it would be getting close to 95% if not greater suppression of scalp DHT, though this is just a guess.

One thing is for sure when placed on my scalp, it is certainly being absorbed. I can feel its effect on my scalp and via some of the other side effects.

Complete thread:

• Why would anyone use oral dutasteride instead of topical? - Goingallout, 28.04.2008, 16:07
  • Why would anyone use oral dutasteride instead of topical? - brm, 28.04.2008, 18:17
    • Why would anyone use oral dutasteride instead of topical? - cal, 10.05.2008, 04:22
      • Why would anyone use oral dutasteride instead of topical? - fckhrls, 10.05.2008, 19:33
  • Why would anyone use oral dutasteride instead of topical? - fckhrls, 10.05.2008, 19:32
  • How do you make the mixture? - Arch Koven, 15.05.2008, 13:21