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For Labmouse........... (Hair Multiplication & Research)

posted by TheOne, 28.04.2008, 16:49

» I only had time to skim the articles, but did get the gist of them.
»
»
» We know via Example 7 of the patent, that Cotsorailis was able to wound
» human skin on a SCID mouse and regenerate hair. But there are two factors
» here that are different from bald scalp. Number one, the skin was
» donor-area skin obtained from a strip transplant, and number two the mice
» dont have an immune system.
»
»
» I actually feel VERY GOOD about Follica being able to make more hair back
» in the donor area. Im pretty darn confident about that, and their process
» could be an adjunt to a FUE-transplant (not a strip). However, I do wonder
» if the thinner (missing a water layer and a layer of fatty acids) frontal
» scalp will be an enouraging environment for hair follicles to form de
» noveau.
»
» We know, because single hair follicles are moved from the back to the
» front all the time in hair transplantation, that the genetics to
» miniaturize are held within the individual philosebaceous unit. The big
» difference between balding follicles and non-balding follicles is probably
» cag-repeats on the androgen receptor gene and the ectodysplasin gene that
» went along with the androgen receptor gene when skin was growing over a
» persons head in the first trimester of embryological development. The
» "waves" and hair grain and wreath shape are almost certainly determined at
» this time. Balding scalp hair follicles have more stable androgen receptors
» than occipital scalp follicles and more alpha five reductase activity in
» the hairs root sheaths--making more DHT prevalent in balding scalp.
»
»
» I want follica to get on with it and see what they have got. If they can
» just make more hair in the donor area..............its really all we need
» in conjunction with a hair transplant. If they can make hair on bald scalp,
» so much the better. However...........it would seem that hair made on bald
» scalp might have the same genetic tendency to miniaturize so one would have
» to be on an anti-androgen to avoid that unless particular genes can be
» blocked from expressing themselves during the ten or so day period when
» these hairs are made. Thats a tall order, but if they can actually make
» hairs on the bald scalp its something that could be down the line in the
» future. Being on an anti-androgen during the days the follicle forms is
» probably important. High androgens in pregnancies manifest themselves in
» finger digit ratios in the offspring, showing that they do indeed make a
» difference. This wounding-healing period is a "second chance" to make
» hair--------so some things can perhaps be controlled for. Cyclosporin,
» anti-histamines, minoxidil, and anti-androgens are all in the patent
» literature. There are almost assuredly going to use all of that.
»
»
» I keep in mind also, in reference to this board, that some of these men
» have invested in ICX and Aderans stock and dont want to see Follica have
» success. Hence you see some negativity. Some people dont want follica to
» succeed for ideological reasons because their success would represent the
» death of a few kooky baldness theories. I hope Follica works, because if it
» doesnt, I realize it will be several years before anything else might work.
» HM obviously is a good ways off since ICX will have to go through a phase
» three trial even if their product is "decent". I have a strong inclination
» to believe ICX isn't growing that much hair, and Aderans is trying to grow
» hair outside the body for re-implantation as fully differentiated hairs
» (and not mere cells). Thats going to be a few years yet...........probably
» 2012 at the earliest if you do the math for completing phase two, the year
» review, phase three, year review...........MHRA review, actual release.
» ACELL is probably working in animals by a much similar process as follica
» does............the ACELL powder will probably be found over time to eitehr
» be suppressing EGF or increasing WNT or bone marrow protien or beta
» catenin, etc. So if Follica doesn't work in human bald scalp, ACELL very
» well might not either. I hope they both work like charms and end baldness,
» but I try to keep my feet on the ground.


Regarding the fact that frontal scalp loses a water layer, Follica are saying their method induces embryonic follicle formation, as we originally had as fetuses.
Do you think this will have any impact on the frontal scalp? I.e regenerating the lost water layer and creating the optimum environment for follicle formation and hair growth?


TheOne is located in [NA] and he is available to meet: NO

Complete thread:

• Studies that back up Follica Research- For Benji and Co. - Labmouse, 28.04.2008, 12:37 (Hair Multiplication & Research)
  • Studies that back up Follica Research- For Benji and Co. - biston, 28.04.2008, 15:57
    • Studies that back up Follica Research- For Benji and Co. - TheOne, 28.04.2008, 16:08
      • Studies that back up Follica Research- For Benji and Co. - biston, 28.04.2008, 16:21
        • Studies that back up Follica Research- For Benji and Co. - TheOne, 28.04.2008, 16:43
        • Studies that back up Follica Research- For Benji and Co. - MPB, 28.04.2008, 21:03
    • For Labmouse........... - benji, 28.04.2008, 16:23
      • For Labmouse........... - TheOne, 28.04.2008, 16:49
        • For Labmouse........... - benji, 28.04.2008, 20:04
          • For Labmouse........... - cal, 28.04.2008, 20:33
            • For Labmouse........... - MPB, 29.04.2008, 15:46
          • For Labmouse........... - TheOne, 28.04.2008, 20:57
            • For Labmouse........... - Willy, 28.04.2008, 22:13
          • For Labmouse........... - TAGOHL, 29.04.2008, 10:16
      • For Labmouse........... - biston, 28.04.2008, 20:56
        • For Labmouse........... - BRUTUS, 29.04.2008, 10:47
          • For Labmouse........... - cal, 29.04.2008, 14:33
          • thanks BRUTUS - benji, 29.04.2008, 19:09
            • thanks BRUTUS - cal, 30.04.2008, 20:54
              • thanks BRUTUS - widowswannabe, 01.05.2008, 00:27
                • thanks BRUTUS - costanza, 01.05.2008, 07:55
                  • thanks BRUTUS - widowswannabe, 02.05.2008, 01:08