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Some Elaine Fuchs info.................... (Hair Multiplication & Research)

posted by benji, 04.05.2008, 23:52

ever since an experiment performed a few years back that moved vellus hairs from bald men to SCID mice with low androgen levels that saw the vellus hairs regenerate to grow as well as donor area hairs.....................scientists have been wondering what it is that is keeping hairs on men who take finasteride or dutasteride or have been castrated small. What keeps them from growing back in us. Stumptailed macaques on finasteride grow back more hair than people do. When men get on finas, they usually get a little thickening in the crown but just either stop or (usually) slow further loss up in the front. Since we know that vellus hairs can regenerate on the mice without immune systems.......................its been assumed that some substance or immunological marker is keeping the vellus hairs small by interrupting some signalling that needs to take place. The search has been to find what this substance is. There are various kinds of receptors on hair follicles for substnaces that regulate the haircycle like estrogen receptors, androgen receptors, prostaglandin receptors, and a few more. Various cytokines, peptides, anti-gens have all been suggested to be "the" culprit that keeps hairs on men in the vellus state after they use something like dutasteride, and why men dont get more hair back on these anti-androgens.


Fuchs has apparently found a substance that she feels is keeping the hairs "small", but there may be more than one. Prostaglandin D2 has been shown by Cotsarialis to be able to keep mice hair from entering a regrowth cycle after their first shed for instance. The substance Fuchs found apparently keeps hairs from getting the "go" signal. Tyrosine kinease inhibitors (there is a new patent out for them with hair growth) have also been suggested to be the substance that keeps hairs from getting the "grow" signalling it needs for stem cells to go to work to initiate a new anagen phase. It was thought for a long time that the excessive collagenous deposition around the follicle physically was blocking it from being able to grow, but one man's experience with internal spironolactone would seem to invalidate that assertion. I dont have it with me, but a guy who had been bald for 20 years was on internal spironolcatone for 6 years for cirrhosis, and he started to grow back some of his hair all over his head............even in the front. Its a safe bet that after being bald for so long, he'd have alot of collagen "shiny scalp" in the dermal sheath, and crosslinked as all get out, yet the hair apparently after a long while of getting no male hormone (spiro being an androgen receptor blocker) still had the capacity to grow if deprived of male hormone long enough and completely enough. The Dermal Papilla can apparently secrete enzymes (dr. Kevin McElwee wrote this) that can eat through the collagen.


Im not crazy about (even though it would be an elegant solution) trying to regrow long lost hair. I really would rather they could make NEW hair and attempt to block certain genes during its development (or make it out of donor hair cells) that would make the new hair androgen-resistant or have a lower androgen-receptor expression, but will take hair any way I can get it. Someday in the future...................they will figure out what makes hair tick and why it gradually goes in response to male hormone, but its probably decades away as the whole thing is so damned complicated. There are 8 sub-stages of anagen, catagen, telogen...........the stem cells migrate down from the arrector pilli muscle at the beginning of a new anagen and meet other cells that migrate from the dermal sheath (if I remember correctly) and the DP dives down in the dermis and begins to get fatter, and kertainocyte cells begin to replicate and enlarge..................all to cause a new anagen phase. Its very complicated. Nonetheless..............the 'capacity' is there for the hair to re-grow that is miniaturized all over your scalp. If we could just shut off certain genes topically..............it might regrow, or if we could change the genetic expression of the hairs to be like body or beard hairs and LIKE testosterone, it would probably regrow. But those things are way out there in the future. Hair cycles themselves might be chemo-preventive as certain growth factors (mitogens) might need to be periodically shut off for a few weeks to give the area around the follicle a break for them or something. Ive seen that speculated by scientist.


Its another nice find...................but one that might be a ways off in terms of having a treatment derived from it, but every little piece of the puzzle gets them closer to finding out what makes hair tick. Hopefully someday, they will be able to give you a topical to use once a week or something and you'd never lose your hair and regrow any that youve lost but its way out there.


benji is located in [NA] and he is available to meet: NO

Complete thread:

• Some Elaine Fuchs info.................... - benji, 04.05.2008, 22:19 (Hair Multiplication & Research)
  • Some Elaine Fuchs info.................... - Arch Koven, 04.05.2008, 23:02
    • Some Elaine Fuchs info.................... - benji, 04.05.2008, 23:52