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IHTI Newsletter, Summer 2008 - The Cole Hair Transplant Group
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Fifth International Congress of Hair Research (Hair Multiplication & Research)

posted by Arch Koven, 07.05.2008, 03:46

» I noticed this posted on another site
» http://www.nahrsmembers.org/home/Portals/0/meetings_support/abstracts_5th_congress/Final_Program_from_Bristol.pdf
»
»
» Lots of great speakers. For example
»
» Page 25
» Hair Follicle Stem Cells – Epithelial
» Speaker: George Cotsarelis, MD
» University of Pennsylvania, Philadelphia, PA, USA
» Over 15 years ago, we proposed that quiescent keratinocytes in the hair
» follicle bulge were epithelial stem cells important for hair follicle
» cycling, epidermal renewal, wound healing and carcinogenesis. Since that
» time, we identifi ed cytokeratin 15 (K15) expression as a marker for these
» cells and developed several transgenic mouse models using the K15 promoter
» to further study the bulge cells. Using K15-EGFP mice, we isolated bulge
» cells and demonstrated that they possessed an epithelial stem cell
» phenotype of quiescence, high proliferative potential and multipotency. We
» also characterized the cells at the molecular level using microarrays and
» identifi ed approximately 150 differentially expressed genes in these
» cells. Through genetic lineage analysis using an inducible K15-CrePR;R26R
» bigenic mouse, we showed that bulge cells generate all of the epithelial
» lineages within the lower anagen hair follicle. However, ablation of bulge
» cells using K15-thymidine kinase mice resulted in permanent hair loss but
» survival of the epidermis. Over a prolonged period, bulge cells did not
» contribute to epidermal homeostasis, but in response to wounding bulge cell
» progeny rapidly moved into the wound area to assist in reepithelialization.
» Bulge derived cells did not persist in the epidermis indicating that
» epidermal stem cells and hair follicle stem cells are distinct populations
» each with self renewing capabilities.
»
»
» Page 41
» Wnt-Dependent De Novo Hair Follicle
» Regeneration in Adult Mouse Skin
» Following Wounding
» Ito, Mayumi; Yang, Zaixin; Andl, Thomas; Cui, Chunhua;
» Kim, Noori; Millar, Sarah; Cotsarelis, George; Department of
» Dermatology, University of Pennsylvania School of Medicine,
» Philadelphia, PA, USA
»
» The mammalian hair follicle is a complex “miniorgan” thought to form only
» during development; loss of an adult follicle is considered permanent. Here
» we show that, after wounding, hair follicles form de novo in genetically
» normal adult animals. The regenerated hair follicles establish a stem cell
» population, express known molecular markers of follicle differentiation,
» produce a hair shaft, and progress through all stages of the hair follicle
» cycle. Lineage analysis demonstrated that the nascent follicles arise from
» epithelial cells outside of the hair follicle stem cell niche, suggesting
» that epidermal cells surrounding the wound assume a hair follicle stem cell
» phenotype. Inhibition of Wnt signaling after reepithelialization completely
» abrogates this wounding induced folliculogenesis, while overexpression of
» Wnt ligand in the epidermis increases the number of regenerated hair
» follicles. These remarkable regenerative capabilitie of the adult support
» the notion that wounding induces an embryonic phenotype in skin, and that
» this provide a window for manipulation of hair follicle neogenesis by Wnts.
» These findings suggest novel treatments for wounds, hair loss and other
» degenerative skin disorders.
so if its really just as simple as a wound producing new hair follicles, couldnt everyone here just take a needle and prick the top of their head a bunch of times?

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