Hair Loss - Robotic Expansion of Cells for Use in Tissue

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Robotic Expansion of Cells for Use in Tissue (Hair Multiplication & Research)

posted by rev, your nightmares, 07.05.2008, 04:26

just quickly skimming through the document, I found some stuff from Dr Kemp

Page 113
Robotic Expansion of Cells for Use in Tissue
Engineering of Hair
Kemp, Paul D.; Intercytex, Manchester, UK
In order for hair multiplication by follicular cell implantation to be a practical proposition, the number of cells returned to the patient must be significantly greater than the number harvested. Moreover, for this process to be commercially successful and cover the high costs of cell culture, amanufacturing facility must have the capacity to expand the cells of many patients simultaneously. For safety reasons, each culture must be maintained in total isolation from the others to ensure that no cross-contamination can occur between the various patients’ cells. This has been a long standing issue with organisations involved in tissue engineering, especially those involved in autologous therapies. Three basic approaches have been employed to deal with the issues, and all three will be presented and their advantages and disadvantages discussed. Intercytex is following a strategy based on a robotic cell culture system that was previously developed and proven in the area of high throughput screening. This system uses standard tissue culture vessels and dispensers to feed and passage mammalian cells although they are net yet approved by regulators for use in tissue engineering. The adoption of a robotic system will impact research decisions made early in the development of a cell culture process so that the process will be made “robot friendly”. The system will be presented and the route to regulatory approval discussed.


Large Scale Manufacturing of Cell Therapy
For Hair Regeneration
Kemp, Paul D.; Intercytex, Manchester, UK
The implantation of follicular cells, expanded in culture, to induce potentially unlimited amounts of hair has been suggested ever since the work of Oliver and Jahoda. Companies are currently in Phase I and II studies to test preparations of cells for hair induction. It seems from the long history of research in this area that processes will soon be developed to successfully achieve this long sought after treatment. But how will these processes be translated into an industry whereby thousands or hundreds of thousands of people could be treated annually? Tissue Engineering is an industry now in its third decade and over a quarter of a million people have been treated by a variety of cultured cell constructs. The early pioneers developed processes often by trial and error, and only now is “best practise” beginning to emerge. The lessons learned in the past are crucial to the current development of tissue engineered hair and are the subject of this presentation. All tissue engineering processes can be broken down into six stages: “Tissue Procurement; “Cell Isolation”; “Cell Expansion”; “Assembly”; “Shipping”; and “Application”. Regulations, industry standards, and developments in other fields are rapidly evolving and influencing each of these stages. The talk will cover these six stages and describe how an industrial process could be developed to meet the commercial needs of large scale follicular cell implantation.


rev is located in YOUR NIGHTMARES and he is available to meet: NO

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