Hair Loss

IHTI Newsletter, Summer 2008 - The Cole Hair Transplant Group
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Proto-Hair Development In Vitro (Hair Multiplication & Research)

posted by rev, 07.05.2008, 05:07

odd comment about growth/ direction issues (In bold)

Page 114
Proto-Hair Development In Vitro
Qiao, Jizeng; Turetsky, Anya; Teumer, Jeff; Intercytex, Woburn, MA, USA
Objectives: To develop an in vitro system in which to grow partially formed hair follicles that, when implanted, will continue to develop into fully formed hairs.

Approach: Hair follicle cells were prepared by enzymatic digestion followed by two sequential sievings. Cell aggregates were made and cultured to allow proto-hair development in vitro. Both freshly made and cultured aggregates were implanted onto an immune deficient mouse ear skin to test for mature hair development. Results: Aggregates made with freshly isolated cells consistently developed hairs after implantation. Aggregates cultured in vitro consistently developed proto-hairs, which are partially formed hair follicles with distinctive morphology. Such in vitro-produced proto-hairs further developed into mature hairs after implantation. Most implants developed hairs that grew out of the skin, while some developed underneath the skin surface but failed to emerge. Histological studies confirmed immature hair structures formed from cell aggregates during cultivation in vitro.

Conclusion:
• We demonstrated that proto-hairs can be produced in vitro from cultured cells.
• We proposed a concept of the immature ‘proto-hair’ as an option for clinical transplantation.

Complete thread:

• Fifth International Congress of Hair Research - rev, 07.05.2008, 02:05 (Hair Multiplication & Research)
  • Fifth International Congress of Hair Research - Arch Koven, 07.05.2008, 03:46
    • Fifth International Congress of Hair Research - rev, 07.05.2008, 03:49
      • Fifth International Congress of Hair Research - HanginInThere, 07.05.2008, 04:40
    • Fifth International Congress of Hair Research - MPB, 07.05.2008, 07:37
    • Fifth International Congress of Hair Research - benji, 07.05.2008, 13:13
  • Robotic Expansion of Cells for Use in Tissue - rev, 07.05.2008, 04:26
    • Robotic Expansion of Cells for Use in Tissue - HanginInThere, 07.05.2008, 04:40
  • Proto-Hair Development In Vitro - rev, 07.05.2008, 05:07
  • So What's Ken Washenik up to... - rev, 07.05.2008, 05:13
    • this is great... - SPQR, 07.05.2008, 12:14
      • this is great... - benji, 07.05.2008, 13:23
        • this is great... - SPQR, 07.05.2008, 16:17
        • this is great... - AJ, 07.05.2008, 16:25