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Dr. Sinclair, Sirtris Pharmaceutical (Topicals)

posted by Steve78, 14.05.2008, 22:47

Yes, I saw this on 20/20 too. This is on their website.

Dr. Sinclair, Sirtris Pharmaceutical

Sirtris Pharmaceuticals – Treating Disease by Modulating Sirtuins

Over the past 70 years, scientists have shown that calorie restriction, or the reduction of normal calorie intake by at least 30-40%, extends healthy lifespan in multiple species, including mice and rats. In addition, calorie restricted animals showed improvement in a number of factors associated with Type 2 Diabetes, including glucose levels, insulin sensitivity and weight gain. Recently published animal studies, including articles in Cell and Nature in 2006, suggest that beneficial effects of calorie restriction are triggered by activation of SIRT1.


Our most advanced programs are focused on developing activators of SIRT1 and include SRT501, our proprietary formulation of resveratrol. Resveratrol is a natural substance found in red wine and other plant products. SRT501 has been shown in animal studies to be a more stable formulation of resveratrol that results in higher drug levels in blood. SRT501 is in Phase 1b clinical trials for Type 2 Diabetes, a disorder characterized by, among other things, high glucose levels. We have also discovered several novel small molecule activators of SIRT1. One of these small molecules, at one-tenth the dose, is as effective as SRT501 at reducing glucose levels and improving insulin sensitivity in an established animal model of Type 2 Diabetes known as the diet-induced obesity (DIO) mouse model.


We believe we are the leading company focused on discovering and developing drug candidates that target sirtuins, and, in particular, drug candidates that mimic the beneficial effects of calorie restriction by activating SIRT1. Our scientific founder and members of our scientific advisory board include many of the leading researchers in the sirtuin field. We have exclusively licensed or own over 100 patents and patent applications pertaining to sirtuins and their role in diseases of aging. Members of our management have previously advanced more than twenty small molecule drugs into clinical trials and played key roles in developing several FDA-approved drugs.

Complete thread:

• Starting new topical and need input - jeff u, 12.05.2008, 22:22 (Topicals)
  • Starting new topical and need input - Pete2, 13.05.2008, 15:37
    • Starting new topical and need input - jeff u, 13.05.2008, 22:38
      • Starting new topical and need input - ipod, 13.05.2008, 23:50
        • Starting new topical and need input - brm, 14.05.2008, 09:34
          • Starting new topical and need input - jeff u, 14.05.2008, 13:03
            • Starting new topical and need input - HanginInThere, 14.05.2008, 19:20
        • Starting new topical and need input - HanginInThere, 14.05.2008, 19:19
          • Starting new topical and need input - jeff u, 14.05.2008, 19:33
            • the study is not the real world - HanginInThere, 14.05.2008, 20:45
              • the study is not the real world - jeff u, 14.05.2008, 21:35
                • the study is not the real world - HanginInThere, 14.05.2008, 21:44
      • Starting new topical and need input - Jacob, 15.05.2008, 20:13
  • Dr. Sinclair, Sirtris Pharmaceutical - Steve78, 14.05.2008, 22:47