Hair Loss - MDF topical from Samson Therapeutics

classified ads


shop
Forum News Hair Transplant Hair Replacement Topical All Natural Drugs Hair Multiplication Gallery Female Hair Loss

Hair Loss

Forum Index   Personal Journal   Poll

Log in | User | Register

Search:  
Back to forum
Board view

Hair Transplant Reviews & Patient Records
 click here
 

MDF topical from Samson Therapeutics (Topicals)

posted by HairSite Admin Homepage, 24.05.2008, 12:34

I was able to find out one study regarding topical flutamide (an old study though)
Analysis of 0-120 hr urine shows at least 16% of the applied flutamide is absorbed.




J Invest Dermatol. 1976 Jun;66(6):379-82

Percutaneous penetration and metabolism of topical (14C)flutamide in men

This study was designed to determine the fate of the nonsteroid antiandrogen flutamide in men following a single 6-hr topical application of 5 mg 14C-labeled drug dissolved in 50% ethanol/50% propylene glycol.

Analysis of 0-120 hr urine shows at least 16% of the applied flutamide is absorbed. Fifty-six percent of the dose is recovered from the site of application with cotton swabs moistened with 50% ethanol/50% propylene glycol.

Flutamide plasma levels peak in 4 to 6 hr at about 1.3 ng/ml and then decline rapidly to about 0.08 ng/ml 24 hr after application. Only 13% of plasma 14C is associated with flutamide 6 hr after drug application.


There are at least 10 plasma metabolites, of which 6 have been tentatively identified. These are alpha, alpha, alpha-trifluoro-4'-amino-m-acetotoluidide (A); alpha, alpha, alpha-trifluoro-4'-amino-2-methyl-m-lactotoluidide (B); alpha, alpha, alpha-trifluoro-4'-nitro-m-acetotoluidide (C); alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide (D); alpha, alpha, alpha-trifluoro-4'-amino-2-methyl-m-propionotoluidide (E); and alpha, alpha, alpha-trifluoro-6-nitro-m-toluidine (F).


(D) is the major plasma metabolite, and its concentration exceeds flutamide's between 8 and 24 hr after drug. All the plasma metabolites are found in 0-24 hr urine in minor amounts. An additional metabolite, alpha, alpha, alpha-trifluoro-amino-5-nitro-p-cresol (G), accounts for 27% of urine 14C.


HairSite Admin is located in [NA] and he is available to meet: NO

---
I offer research assistance for HairSite.
email: hairsite@aol.com for free consultations
=====================================
reminder:
1. Help China Earthquake Victims
2. Free hair replacement system for men & women

Post reply
 

Complete thread:

Back to forum
Board view
38669 Postings in 3571 Threads, 1614 registered users
Hair Loss | Admin contact
powered by MLF | FORUM POLICY

Dr. Klein's REMOX: most comprehensive topical hair loss therapy
click here