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MDF topical from Samson Therapeutics (Topicals)

posted by RonLev, 24.05.2008, 20:01

» » MDF is specfically formulated to take advantage of the most potent DHT
» » inhibitor (dutasteride) and the most potent DHT blocker (flutamide).
» » To say that they are "unproven" means that you have ignored the medical
» » literature for the past 25 years (in the case of flutamide) and 12
» years
» » (in the case of dutasteride).
»
» As far as I know, there is not so much as even a SINGLE report in the
» medical literature of dutasteride being used topically. Furthermore, even
» after some 25 years, the experience with topical flutamide in humans has
» also been extremely sparse, with (to my knowledge) only a couple of
» published studies on that. Even worse, the studies with topical flutamide
» in animals have shown very serious problems with systemic absorption of the
» drug. Are you and your company aware of all that, and are you prepared for
» the posssible legal consequences that may well occur from the use of your
» product by your trusting customers?
»
»

It is well known that flutamide has a relatively high rate of percutaneous absorption (16% in the study you are undoubtedly referring to, Katchen, 1976), but those studies were using the dosage level for oncologic indications (pro-rated in animal models from a base of 750 mg in humans). In subsequent years, investigators have titrated the dose downward to determine its safe level for nononcologic use. These series of studies were conducted by Muderris in 1999 and 2000, who found that using levels <250 mg were entirely safe (we use the very lowest dose Muderris found that was still effective at 62.5 mg and created the topical equivalent, which results in a systemic absorption of only 10.3 mg--far below the level that produces any systemic effect).

RonLev


RonLev is located in [NA] and he is available to meet: NO

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