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MDF topical from Samson Therapeutics (Topicals)

posted by Bryan, 25.05.2008, 14:13

» » Even worse, the studies with topical flutamide
» » in animals have shown very serious problems with
» » systemic absorption of the drug.
»
» It is well known that flutamide has a relatively high rate of percutaneous
» absorption (16% in the study you are undoubtedly referring to, Katchen,
» 1976), but those studies were using the dosage level for oncologic
» indications (pro-rated in animal models from a base of 750 mg in humans).
» In subsequent years, investigators have titrated the dose downward to
» determine its safe level for nononcologic use. These series of studies
» were conducted by Muderris in 1999 and 2000, who found that using levels
» <250 mg were entirely safe (we use the very lowest dose Muderris found that
» was still effective at 62.5 mg and created the topical equivalent, which
» results in a systemic absorption of only 10.3 mg--far below the level that
» produces any systemic effect).
I'm pleased to know that the ABSOLUTE quantity of absorbed flutamide from a typical application/dose of your product is probably low enough not to present any obvious toxic symptoms, but nevertheless I was mainly referring in my post above to the animal studies(1,2) showing that topically-applied flutamide works entirely by SYSTEMIC absorption. In other words, I'm not aware of any scientific studies showing a "local" effect of topical flutamide except for that one Sintov study, and I don't consider that one to be entirely persuasive. Do you and your company realize that what you're doing is putting out a VERY expensive product which uses a potentially VERY toxic drug which is based on exactly ONE rather questionable animal experiment claiming a certain degree of "local" efficacy?

1) "Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity." J Invest Dermatol 1995 Nov;105(5):678-82.

2) "The effects of a nonsteroid antiandrogen, flutamide, on sebaceous gland activity". J Invest Dermatol 64:412-417, 1975.


Bryan is located in [NA] and he is available to meet: NO

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