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Let's carefully specify the meaning of a "local" effect! (Topicals)
» » Bryan,
» »
» » It appears that you stand, on principle, that any drug that is
» » systemically absorbed would make topical application worthless since,
» as
» » you say "you might as well just take it orally" and be done with it.
» » However, that flies in the face of standard dermatologic practice.
» Drugs
» » in multiple therapeutic classes (all manifesting systemtic absorption)
» are
» » compounded in topical formulations to concentrate the effect at the
» point
» » of application. For example, topical corticosteroids all manifest
» systemic
» » absorption, but dermatologists use topical formulations because they
» can
» » use lower doses and still obtain effectiveness in the skin (for
» treating
» » eczema, allergic dermatitis, etc.), GRANTED that some of the steroids
» will
» » be systemtically absorbed. The same applies to topical antibiotics, et
» » al.
»
» Did you miss the whole point of my previous posts? I demonstrated to you
» with the graph from the Chen et al study that the effect of the
» topical flutamide was absolutely, positively NOT concentrated at the point
» of application. I took pains to point out that the results on both flank
» organs were IDENTICAL, even though the drug was applied only to one flank
» organ. Now do you understand the point that I've been making all along?
» The flutamide was acting in those rodent studies EXCLUSIVELY by a systemic
» route.
»
» Likewise, you are missing my point; I am not concerned about systemic activity at the flank organ--I already acknowledged that flutamide is systemically absorbed. What a dermatologist wants to know is: what is the activity of flutamide at the skin site of administration and what happens to that activity in the skin when the dose is titrated downward so that systemic activity is extinguished? (That was not the objective of Chen's experiment.)
RonLev
RonLev is located in [NA] and he is available to meet: NO
Complete thread:
- MDF topical from Samson Therapeutics
- RonLev, 10.05.2008, 20:29 (Topicals)
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- MDF topical from Samson Therapeutics
- helpmeout, 11.05.2008, 22:51
- MDF topical from Samson Therapeutics
- Jtelecom, 12.05.2008, 13:32
- MDF topical from Samson Therapeutics - benji, 12.05.2008, 14:24
- MDF topical from Samson Therapeutics
- ipod, 13.05.2008, 23:48
- MDF topical from Samson Therapeutics
- brm, 14.05.2008, 10:08
- MDF topical from Samson Therapeutics - cal, 14.05.2008, 21:16
- MDF topical from Samson Therapeutics
- brm, 14.05.2008, 10:08
- MDF topical from Samson Therapeutics
- RonLev, 21.05.2008, 14:40
- MDF topical from Samson Therapeutics - Jtelecom, 21.05.2008, 19:13
- MDF topical from Samson Therapeutics
- Bryan, 22.05.2008, 00:35
- MDF topical from Samson Therapeutics - RNORAM, 23.05.2008, 15:15
- MDF topical from Samson Therapeutics
- HairSite Admin, 24.05.2008, 12:34
- MDF topical from Samson Therapeutics - Bryan, 24.05.2008, 12:48
- MDF topical from Samson Therapeutics
- RonLev, 24.05.2008, 20:01
- MDF topical from Samson Therapeutics
- Jtelecom, 24.05.2008, 21:10
- MDF topical from Samson Therapeutics
- RonLev, 24.05.2008, 22:15
- MDF topical from Samson Therapeutics - Hairloss_in_bed, 24.05.2008, 22:38
- MDF topical from Samson Therapeutics - Bryan, 25.05.2008, 14:27
- MDF topical from Samson Therapeutics
- RonLev, 24.05.2008, 22:15
- MDF topical from Samson Therapeutics
- Bryan, 25.05.2008, 14:13
- MDF topical from Samson Therapeutics
- RonLev, 25.05.2008, 15:40
- MDF topical from Samson Therapeutics - Jtelecom, 25.05.2008, 16:21
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 25.05.2008, 19:20
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 25.05.2008, 20:08
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 25.05.2008, 21:19
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 25.05.2008, 22:03
- Ron Lev, topical flutamide robbed me of hard ons............
- benji, 26.05.2008, 00:16
- Ron Lev, topical flutamide robbed me of hard ons............ - RonLev, 26.05.2008, 11:43
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 26.05.2008, 00:52
- Let's carefully specify the meaning of a "local" effect! - RonLev, 26.05.2008, 11:29
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 26.05.2008, 14:48
- Topical FLUTAMIDE will rob you of erections. It did to me - benji, 26.05.2008, 16:48
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 27.05.2008, 16:52
- NOBODY IS CLAIMING Dutasteride or Finasteride only have local effects
- benji, 27.05.2008, 18:39
- NOBODY IS CLAIMING Dutasteride or Finasteride only have local effects
- RonLev, 27.05.2008, 20:55
- RonLev is lying about my side effects with FLUTAMIDE - benji, 27.05.2008, 23:36
- NOBODY IS CLAIMING Dutasteride or Finasteride only have local effects
- RonLev, 27.05.2008, 20:55
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 28.05.2008, 04:34
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 28.05.2008, 12:11
- Apparently RU58841 available for licensing - goata007, 28.05.2008, 15:30
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 28.05.2008, 17:17
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 30.05.2008, 20:27
- RonLev, why aren't you answering my questions?
- Bryan, 31.05.2008, 16:57
- RonLev, why aren't you answering my questions?
- Jacob, 31.05.2008, 17:01
- RonLev, why aren't you answering my questions?
- Bryan, 31.05.2008, 17:16
- RonLev, why aren't you answering my questions?
- Jacob, 31.05.2008, 17:47
- RonLev, why aren't you answering my questions?
- Bryan, 31.05.2008, 18:53
- RonLev, why aren't you answering my questions?
- Jacob, 31.05.2008, 20:31
- RonLev, why aren't you answering my questions?
- Bryan, 01.06.2008, 00:09
- RonLev, why aren't you answering my questions?
- RonLev, 01.06.2008, 16:42
- RonLev, why aren't you answering my questions?
- Bryan, 02.06.2008, 01:07
- RonLev, why aren't you answering my questions?
- RonLev, 03.06.2008, 20:44
- RonLev, why aren't you answering my questions? - Bryan, 04.06.2008, 05:12
- RonLev, why aren't you answering my questions?
- RonLev, 03.06.2008, 20:44
- RonLev, why aren't you answering my questions?
- Bryan, 02.06.2008, 01:07
- RonLev, why aren't you answering my questions?
- RonLev, 01.06.2008, 16:42
- RonLev, why aren't you answering my questions?
- Bryan, 01.06.2008, 00:09
- RonLev, why aren't you answering my questions?
- Jacob, 31.05.2008, 20:31
- RonLev, why aren't you answering my questions?
- Bryan, 31.05.2008, 18:53
- RonLev, why aren't you answering my questions?
- Jacob, 31.05.2008, 17:47
- RonLev, why aren't you answering my questions?
- Bryan, 31.05.2008, 17:16
- RonLev, why aren't you answering my questions?
- Jacob, 31.05.2008, 17:01
- RonLev, why aren't you answering my questions?
- Bryan, 31.05.2008, 16:57
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 30.05.2008, 20:27
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 28.05.2008, 12:11
- NOBODY IS CLAIMING Dutasteride or Finasteride only have local effects
- benji, 27.05.2008, 18:39
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 26.05.2008, 14:48
- Let's carefully specify the meaning of a "local" effect! - RonLev, 26.05.2008, 11:29
- Ron Lev, topical flutamide robbed me of hard ons............
- benji, 26.05.2008, 00:16
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 25.05.2008, 22:03
- Let's carefully specify the meaning of a "local" effect!
- Bryan, 25.05.2008, 21:19
- Let's carefully specify the meaning of a "local" effect!
- RonLev, 25.05.2008, 20:08
- MDF topical from Samson Therapeutics
- RonLev, 25.05.2008, 15:40
- MDF topical from Samson Therapeutics
- Jtelecom, 24.05.2008, 21:10
- MDF topical from Samson Therapeutics
- Jtelecom, 12.05.2008, 13:32
- MDF topical from Samson Therapeutics
- El_Duterino, 28.05.2008, 00:16
- MDF topical from Samson Therapeutics
- RonLev, 28.05.2008, 12:42
- MDF topical from Samson Therapeutics
- Bryan, 28.05.2008, 17:47
- Too bad flutamide gives you the limp-noodle.....because it works
- benji, 30.05.2008, 23:10
- Too bad flutamide gives you the limp-noodle.....because it works
- goata007, 31.05.2008, 01:30
- Too bad flutamide gives you the limp-noodle.....because it works
- benji, 31.05.2008, 01:36
- Too bad flutamide gives you the limp-noodle.....because it works
- El_Duterino, 31.05.2008, 03:18
- Too bad flutamide gives you the limp-noodle.....because it works
- benji, 01.06.2008, 19:50
- Too bad flutamide gives you the limp-noodle.....because it works
- El_Duterino, 02.06.2008, 00:48
- Too bad flutamide gives you the limp-noodle.....because it works
- RNORAM, 04.06.2008, 21:15
- Too bad flutamide gives you the limp-noodle.....because it works - El_Duterino, 05.06.2008, 00:08
- Too bad flutamide gives you the limp-noodle.....because it works
- RNORAM, 04.06.2008, 21:15
- Too bad flutamide gives you the limp-noodle.....because it works
- El_Duterino, 02.06.2008, 00:48
- Too bad flutamide gives you the limp-noodle.....because it works
- benji, 01.06.2008, 19:50
- Too bad flutamide gives you the limp-noodle.....because it works
- El_Duterino, 31.05.2008, 03:18
- Too bad flutamide gives you the limp-noodle.....because it works
- benji, 31.05.2008, 01:36
- Too bad flutamide gives you the limp-noodle.....because it works
- goata007, 31.05.2008, 01:30
- Too bad flutamide gives you the limp-noodle.....because it works
- benji, 30.05.2008, 23:10
- MDF topical from Samson Therapeutics
- Bryan, 28.05.2008, 17:47
- El Duterino question
- rollercoaster1, 05.06.2008, 16:44
- El Duterino question - El_Duterino, 05.06.2008, 19:43
- MDF topical from Samson Therapeutics
- RonLev, 28.05.2008, 12:42
- MDF topical from Samson Therapeutics
- helpmeout, 11.05.2008, 22:51