Hair Loss - Let's carefully specify the meaning of a "local" effect!

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Let's carefully specify the meaning of a "local" effect! (Topicals)

posted by Bryan, 26.05.2008, 14:48

» » Did you miss the whole point of my previous posts?
» » I demonstrated to you with the graph from the Chen
» » et al study that the effect of the topical
» » flutamide was absolutely, positively NOT concentrated
» » at the point of application. I took pains to point out
» » that the results on both flank organs were IDENTICAL,
» » even though the drug was applied only to one flank organ.
» » Now do you understand the point that I've been making all along?
» » The flutamide was acting in those rodent studies EXCLUSIVELY
» » by a systemic route.
 »
» Likewise, you are missing my point; I am not concerned about systemic
» activity at the flank organ--I already acknowledged that flutamide is
» systemically absorbed. What a dermatologist wants to know is: what is the
» activity of flutamide at the skin site of administration and what happens
» to that activity in the skin when the dose is titrated downward so that
» systemic activity is extinguished? (That was not the objective of Chen's
» experiment.)
Ahhh...but that _was_ an objective of Chen's experiment! ;-) I think now you're also beginning to understand why I made such a big point before of the fact that Chen et al tested THREE separate doses: a large dose which strongly reduced flank organ size (identical effect on both sides); a medium dose which moderately reduced flank organ size (identical effect on both sides); and a small dose which had only a very minimal effect on flank organ size (identical effect on both sides).

Sorry about pressing you on all this, but there's just no way to put a favorable "spin" of any kind on the animal experiments with topical flutamide. They demonstrate that (1) topical flutamide works EXCLUSIVELY by a systemic route, and (2) titrating the dose up or down doesn't alter the systemic nature of how it works.

The animal experiments are clearly DISASTROUS for anybody who wants to develop a topical flutamide product for human use. Any rationale one can conjure up for how such a product might be great for humans is soundly contradicted by the results of these animal experiments (with the possible exception of the Sintov study, as I explained before). All you can do now is hope against hope that topical flutamide works by some substantially different mechanism in humans than it does in rodents; and frankly, I consider that to be a pretty weak foundation on which to develop a new product for human use. It doesn't inspire one with confidence.

.


Bryan is located in [NA] and he is available to meet: NO

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