Hair Loss - NOBODY IS CLAIMING Dutasteride or Finasteride only have local effects

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NOBODY IS CLAIMING Dutasteride or Finasteride only have local effects (Topicals)

posted by RonLev, 27.05.2008, 20:55

» » » Bryan,
» »
» ». As I
» » mentioned in response to Benji's unfortunate experience with
» finasteride
» » and dutasteride, even well-established, fully FDA-approved drugs will
» not
» » pass muster by your standard. BENJI HAS BEEN ON
» FINASTERIDE FOR 12 YEARS WITH NO PROBLEM. FLUTAMIDE TOPICALLY IS WHAT GAVE
» HIM NO ERECTIONS, NAUSEA, NO SEX DRIVE, DIARREAH, and you know
» this.............youre simply lying as Ive pointed it out to you the FIRST
» time you tried to intentionally misinterpret what I clearly stated and
» blame finasteride........
»
» That is not to say that your standard is
» » wrong, it is just that the state of the art currently puts us in a
» position
» » where antiandrogenic control cannot be absolutely locally restricted.
» If
» » you want truly effective control of DHT in the here-and-now, this is
» the
» » risk that patients and their doctors must weigh, and for most the
» benefits
» » outweigh the risks. OF DUTASTERIDE, MAYBE. NOT
» FLUTAMIDE. You are worried about sales of your product, most people who buy
» it will only use it a month or two and stop because of the FLUTAMIDE side
» effects. You should have tried to formulate topical dutasteride and
» minoxidil along with some topical ketoconazole and the sides would have
» been small enough for many to keep with it. The FLUTAMIDE sides will make
» them quit. They will feel like shiiiit. Furthermore, Flutamide probably has
» to be metabolized to even work directly as Docjo77 has pointed out at HLT.
» »
»
»
»
»
» The makers of finasteride (MERK) and Dutasteride
» (Glaxo-Smith-Kline) do not claim that their drugs work by any other means
» than systemic absorption. They do not sell topical forumlations thereof. No
» tests anywhere have suggested that these drugs can be used topically and be
» useful unless serum levels of DHT are also affected by the makers. Some
» claim that finasteride can be suspended topically in the right vehicle, but
» its never been proven. Nobody that I know of claims that for dutasteride,
» but even if it worked, one could just drain dutasteride capsules in a
» bottle of minoxidil and get the same effect. If you think you have a
» topical vehicle that can suspend dutasteride topically where it does not
» cross into the bloodstream and only has local effects, commission a study
» and treat AGA topically with it and show no serum changes in DHT. But you
» dont and we both know it.
»
»
»
» You are trying to turn a buck on people's ignorance. Im trying to save men
» from a pretty miserable month or so of life..............which they will
» have if they use flutamide topically.
Benji,

Hold your horses. I never claimed that MDF was not systemically absorbed. The point I want to make is that your treatment with these FDA-approved products by Glaxo TAKEN AS DIRECTED was responsible for significant sexual side effects, yet you direct all of your criticism at MDF. The one claim we can make (aside from the development of a stable solution of these components, which was quite difficult) is that the systemic exposure of these components is lower with MDF than with oral doseforms (10.3 mg of flutamide topically vs. 62.5 mg orally; and 0.25 mg of dutasteride vs. 0.5 mg orally). One issue that mystifies me is why you obsess over flutamide when, on a dose-response basis, there is a greater likelihood of experiencing sexual side effects from dutasteride (since both agents are in MDF, I can comment on this issue without bias).

I regret that you had such a poor experience with dutasteride (and finasteride, as you noted earlier). While you appear to be quite sensitive to antiandrogens, others who have less sensitivity may experience fewer side effects from MDF. Notice I said "may", not "will".

RonLev


RonLev is located in [NA] and he is available to meet: NO

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