Hair Loss - Let's carefully specify the meaning of a "local" effect!

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Let's carefully specify the meaning of a "local" effect! (Topicals)

posted by Bryan, 28.05.2008, 04:34
(edited by Bryan on 28.05.2008, 04:50)

» Bryan,
»
» I appreciate your spirited and scientifically rigorous rebuttals. I
» would only add as a coda to this discussion that many drugs in this field
» (and I am including ALL hormonal modulators in this discussion, not just
» antiandrogens for treatment of hair disorders) are developed with an
» acknowledgement of some risk as a part of their side effect profile. As I
» mentioned in response to Benji's unfortunate experience with finasteride
» and dutasteride, even well-established, fully FDA-approved drugs will not
» pass muster by your standard. That is not to say that your standard is
» wrong, it is just that the state of the art currently puts us in a position
» where antiandrogenic control cannot be absolutely locally restricted. If
» you want truly effective control of DHT in the here-and-now, this is the
» risk that patients and their doctors must weigh, and for most the benefits
» outweigh the risks.

I must take issue with your claim that "even well-established, fully FDA-approved drugs will not pass muster" by my standard. I'm astonished that you would try to take some of the heat off (topical) flutamide by implying that all other antiandrogens are going to have similar risks with systemic absorption. But such is not the case! :-P I'm sure you're aware that topical spironolactone has been thoroughly tested in both animals and humans, and been found to have no detectable systemic absorption (one study applied a spiro cream to literally HALF the entire body surface area of some human test subjects, with no ill effects). Topical spiro may not be all that powerful an antiandrogen, but one feature it _does_ have that topical flutamide apparently doesn't is that all-important "local" antiandrogenic effect.

And what about topical RU58841?? That substance has been thoroughly tested in animals (and at least privately in humans), and probably has the greatest ratio of local-to-sytemic antiandrogenic effect of any substance ever discovered. It has NO known risk of a systemic antiandrogenic effect when applied topically, yet has a very potent "local" effect which has been described as "castration-like" in some of the animal studies.

So I think you're being rather disingenuous by trying to make us believe that all other antiandrogens are going to have the same issues and problems as flutamide, when used topically. But that is clearly NOT the case. When anybody makes an objective comparison of the animal studies with flutamide and the animal studies with (say) RU58841, a huge gulf is seen to exist between the two which stretches out like the Grand Canyon. And yet you're trying to convince us that your new flutamide product is going to be about as good as one can get with the current state of the art. I don't believe that, and I doubt that very many other people believe it, either. The difference between flutamide and RU58841 (at the very least in the animal studies, and that carries a LOT of weight with me) is like the difference between day and night.

.


Bryan is located in [NA] and he is available to meet: NO

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