Hair Loss - Let's carefully specify the meaning of a "local" effect!

classified ads


shop
Forum News Hair Transplant Hair Replacement Topical All Natural Drugs Hair Multiplication Gallery Female Hair Loss

Hair Loss

Forum Index   Personal Journal   Poll

Log in | User | Register

Search:  
Back to forum
Board view

FREE Hair Transplant Consultations with HDC: London - Sep 1-5
 click here
 

Let's carefully specify the meaning of a "local" effect! (Topicals)

posted by RonLev, 30.05.2008, 20:27
(edited by RonLev on 30.05.2008, 21:18)

» » Bryan,
» »
» » In studies directly comparing spironolactone and flutamide,flutamide
» has
» » been shown to be a more potent antiandrogen (Moghetti, P: J. Clin.
» » Endocrinol. Metab. 85(1) 2000).
»
» I acknowledge that flutamide is a generally more powerful antiandrogen
» than spironolactone, at least at the doses of both drugs which are
» typically used. But spironolactone does have one PROFOUND advantage
» over flutamide: it has at least a modest "local" antiandrogenic effect
» when applied topically, but flutamide doesn't have any at all.
»
» If you were a virile young male who is concerned about the possibility of
» developing nasty sexual side effects, which drug would YOU choose to use:
» topical spiro, which has virtually ZERO chance of systemic absorption
» (although its "local" effect is only mild-to-moderate), or topical
» flutamide, which has no "local" effect at all (according to the animal
» studies), and whose antiandrogenic effects come about EXCLUSIVELY by way of
» systemic absorption? :-)
»
» Again I point out that if topical flutamide has no "local" antiandrogenic
» effect at all, there's really no particular reason to use it topically in
» the first place. It would be a lot simpler and far less messy just to
» SWALLOW a proper dose of the drug.
»
» » But more importantly from a practical
» » perspective, spironolactone has an objectionable odor especially when
» » combined with minoxdil and requires a viscid base to remain stable in
» » solution. This imposes a dilemma on patients: they must either
» tolerate
» » the odor or messyness (most do not) or separate the spironolatone
» » application from the minoxidil application--a ritual that quickly
» becomes
» » too bothersome for the patient, who eventually looks for another type
» of
» » treatment.
»
» Dr. Proctor says he's developed a way to keep spironolactone and minoxidil
» stabilized when used together. He uses that technique in Proxiphen (which,
» BTW, has no objectionable odor). That would appear to make a choice of
» topical spironolactone easily preferable to topical flutamide, especially
» considering the other points I've made about the lack of a "local" effect
» with flutamide.
»
» » RU58841 is a wonderful drug that will never see the light of day
» because
» » of the disinterest of Roussel Uclaf (now a part of Aventis) to pursue
» the
» » expense of an FDA approval. (Compounders don't need an FDA approval
» for
» » hair loss, but we are legally bound to use components that are FDA
» approved
» » for some legitimate indication.)
»
» Considering that there's no Federal law (yet) establishing RU58841 as a
» prescription drug, I can't help but question the accuracy of your claim
» that you would be "legally" prohibited from using RU58841, assuming that
» you obtained a license to use it from the company that owns the rights (see
» the other nearby comment from another poster about this same issue).
»
» » Bryan, of course we looked at alternatives that you consider worthy,
» » and there is a reason why we rejected them.
»
» I think you should go back and and reconsider those reasons, taking into
» account what I've said in this thread.
»
»

Bryan,

I'm sorry that my business travels will make my contributions a bit spotty on this forum, but let me say that we, indeed, are looking at licensing and other co-partnering arrangements in the future (I cannot say when or with whom at this time.) But these licensing opportunities all come with obligations. In particular, they require financial reserves and performance guarantees that, as a startup company, we will need to earn first with the sales of MDF.

I should mention that this is more than just an business interest of mine, since I have been using MDF longer than any other patient, and I would want to have available a treatment that is equipotent to flutamide that has fewer side effects. Unfortunately, like many other users of antiandrogens (and I have been treated with many of the antiandrogens commonly available in the U.S. over the past 28 years), I have found that they gradually lose their effectiveness over time. To date, from my experience, only flutamide has had the potency to significantly regrow hair--and to retain that hair--after many years of continuous use in a patient. So our interest in providing any improved hair loss treatment without flutamide must focus on retaining this potency level while reducing or eliminating systemic absorption and the attendant side effects.

RonLev


RonLev is located in [NA] and he is available to meet: NO

Post reply
 

Complete thread:

Back to forum
Board view
36178 Postings in 3343 Threads, 1555 registered users
Hair Loss | Admin contact
powered by MLF | FORUM POLICY

Dr. Klein's REMOX Topical Hair Loss Therapy
 click here